{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:17:05Z","timestamp":1788675425171,"version":"build-2803163510"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Anabolic androgenic steroids (AASs) have long been misused by professional athletes. Easy online and over-the-counter availability of AASs makes it an alluring option even among amateurs for their desired cosmetic and performance-enhancing effects. AASs have been associated with distinct forms of liver injury including transient transaminitis, peliosis hepatis, and hepatic tumors. An acute cholestatic syndrome with bland histology is another characteristic form of liver injury rarely reported with AASs. Plasmapheresis may provide a long-lasting relief of symptoms when conventional pharmacotherapeutic measures fail. Herein, we report a challenging case of a young male with refractory pruritus secondary to AASs, managed effectively with plasmapheresis.<\/jats:p>","DOI":"10.4103\/ajts.ajts_223_23","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:29:47Z","timestamp":1724826587000},"page":"236-238","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Refractory pruritus in cholestatic drug-induced liver injury secondary to androgenic anabolic steroids: Plasmapheresis to the rescue"],"prefix":"10.4103","volume":"20","author":[{"given":"Arpit","family":"Shastri","sequence":"first","affiliation":[{"name":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh Chandragiri","family":"Paranthamaiah","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesha Chinakarihalli","family":"Gangadharappa","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvika","family":"Shastri","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvradeep","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divjot Singh","family":"Lamba","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratti Ram","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arka","family":"De","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"R2-20260529","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1159\/000454674","article-title":"Plasmapheresis for refractory pruritus due to drug-induced cholestasis","volume":"10","author":"Al-Azzawi","year":"2016","journal-title":"Case Rep Gastroenterol"},{"key":"R3-20260529","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3389\/fphar.2018.01321","article-title":"Anabolic androgenic steroids:Searching new molecular biomarkers","volume":"9","author":"Sessa","year":"2018","journal-title":"Front Pharmacol"},{"key":"R4-20260529","doi-asserted-by":"crossref","first-page":"785790","DOI":"10.3389\/fphar.2021.785790","article-title":"Novel therapies for the treatment of drug-induced liver injury:A systematic review","volume":"12","author":"Beni\u0107","year":"2021","journal-title":"Front 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Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_223_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:22:57Z","timestamp":1787844177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_223_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_223_23","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"2023-11-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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