{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:19:25Z","timestamp":1787775565921,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract:<\/jats:title>\n \n BACKGROUND:<\/jats:title>\n Apheresis procedures use citrate as an anticoagulant to ensure the fluidity of extracorporeal blood. Citrate-related toxicities are common adverse effects in peripheral blood stem cell (PBSC) collections as they are lengthy procedures resulting in prolonged citrate exposure. Intravenous (IV) calcium administration during therapeutic apheresis procedures is commonly used to reduce the citrate-related toxicity in adults and pediatric population. Very few literature on the use of oral calcium for the prevention of citrate toxicity during PBSC collection are present.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n The objective of this study was to evaluate the effect of prophylactic oral calcium in reducing citrate-related toxicities during PBSC collections.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n A prospective cross-sectional study was carried out at a tertiary care hospital of Southern India. All participants received calcium carbonate \u2013 1 g before and at each 100 ml of collection. Preprocedure, interim, and postprocedure serum calcium were measured. All procedures were done using Spectra Optia. The ACD (acid-citrate-dextrose) rate were between 1:8 to 1:14 and were adjusted for inlet draw rate. The total blood volume processed between 2.5 to 3 based on body weight. Reduction in calcium levels and adverse reactions due to hypocalcemia were observed. Data were analyzed using SPSS 23 software.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n The majority of the procedures were undisturbed and tolerable to oral calcium. A total of 97.3% of the study subjects did not experience any symptoms of hypocalcemia. Only 2.7% (One autologous and one allogenic donor) had symptoms attributable to hypocalcemia though they had preprocedure calcium >9 mg\/dl. Pre- and postprocedure calcium were compared using a paired\n t<\/jats:italic>\n -test which was statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Prophylactic oral calcium in PBSC collection is an effective and easy way to the prevention of citrate-related adverse effects without affecting technical performance and product efficacy.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ajts.ajts_232_23","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:29:44Z","timestamp":1724826584000},"page":"106-112","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of oral calcium to prevent citrate-related toxicity during peripheral blood hematopoietic stem cell collection \u2013 An experience from a tertiary care center"],"prefix":"10.4103","volume":"20","author":[{"given":"Dibyajyoti","family":"Sahoo","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahida","family":"Noushad","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishekh","family":"Basavarajegowda","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"R2-20260529","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/152581601753193896","article-title":"Adverse events in peripheral progenitor cell collection: A 7-year experience","volume":"10","author":"Moog","year":"2001","journal-title":"J Hematother Stem Cell Res"},{"key":"R3-20260529","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3324\/haematol.13668","article-title":"Severe events in donors after allogeneic hematopoietic stem cell donation","volume":"94","author":"Halter","year":"2009","journal-title":"Haematologica"},{"key":"R4-20260529","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/tme.12205","article-title":"Guideline on the clinical use of apheresis procedures for the treatment of patients and collection of cellular therapy products. British committee for standards in haematology","volume":"25","author":"Howell","year":"2015","journal-title":"Transfus Med"},{"key":"R5-20260529","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1046\/j.1537-2995.2003.00571.x","article-title":"Reduction of adverse citrate reactions during autologous large-volume PBPC apheresis by continuous infusion of calcium-gluconate","volume":"43","author":"Buchta","year":"2003","journal-title":"Transfusion"},{"key":"R6-20260529","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1182\/blood-2008-08-175323","article-title":"Adverse events among 2408 unrelated donors of peripheral blood stem cells: Results of a prospective trial from the national marrow donor program","volume":"113","author":"Pulsipher","year":"2009","journal-title":"Blood"},{"key":"R7-20260529","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1046\/j.1537-2995.2002.00151.x","article-title":"Controlled study of citrate effects and response to i.v calcium administration during allogeneic peripheral blood progenitor cell donation","volume":"42","author":"Bolan","year":"2002","journal-title":"Transfusion"},{"key":"R8-20260529","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/ajts.AJTS_114_17","article-title":"Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study","volume":"14","author":"Pandey","year":"2020","journal-title":"Asian J Transfus Sci"},{"key":"R9-20260529","doi-asserted-by":"crossref","first-page":"103147","DOI":"10.1016\/j.transci.2021.103147","article-title":"Effectiveness of supplemental oral calcium drink in preventing citrate-related adverse effects in peripheral blood progenitor cell collection","volume":"60","author":"Fujii","year":"2021","journal-title":"Transfus Apher Sci"},{"key":"R10-20260529","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jca.20039","article-title":"Complications of donor apheresis","volume":"21","author":"Winters","year":"2006","journal-title":"J Clin Apher"},{"key":"R11-20260529","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.transci.2015.11.015","article-title":"Prophylactic low dose continuous calcium infusion during peripheral blood stem cell (PBSC) collections to reduce citrate related toxicity","volume":"54","author":"Hegde","year":"2016","journal-title":"Transfus Apher Sci"},{"key":"R12-20260529","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1098-1101(1997)12:1<10::AID-JCA3>3.0.CO;2-D","article-title":"Safety of large-volume leukapheresis for collection of peripheral blood progenitor cells","volume":"12","author":"Reik","year":"1997","journal-title":"J Clin Apher"},{"key":"R13-20260529","first-page":"108","article-title":"Effectiveness of low-dose oral calcium carbonate for the prevention of citrate-related toxicity in peripheral blood stem cell collection","volume":"10","author":"Sassi","year":"2012","journal-title":"Blood Transfus"},{"key":"R14-20260529","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1210\/jcem-60-5-874","article-title":"Influence of continuous infusion of citrate on responses of immunoreactive parathyroid hormone, calcium and magnesium components, and other electrolytes in normal adults during plateletapheresis","volume":"60","author":"Toffaletti","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"R15-20260529","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1046\/j.1537-2995.2002.00205.x","article-title":"Treatment for the decline of ionized calcium levels during peripheral blood progenitor cell harvesting","volume":"42","author":"Kishimoto","year":"2002","journal-title":"Transfusion"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_232_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:32:07Z","timestamp":1787772727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_232_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_232_23","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"2023-12-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}