{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:28Z","timestamp":1787840548593,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antigens of the Gerbich (Ge) blood group system are highly prevalent proteins that are expressed on the glycophorin C and glycophorin D of the human erythrocytes. Three phenotypes of Ge-negative red blood cells (RBC) have been identified serologically and genetically. Alloantibodies against Ge antigens are extremely rare and their identification can be clinically significant. The persistence of Ge alloantibodies in the patients\u2019 blood has not been well investigated. Herein we report a case of a patient with osteosarcoma showed anti-Ge alloantibodies by serology testing following blood transfusion. This case has been further genetically tested and showed a Yus phenotype by molecular analysis. The formed anti-Ge alloantibodies disappeared after 9 months of induction. This case has been successfully managed with compatible Ge2-negative frozen packed RBC. This case reports an extremely rare finding in the Palestinian population characterized by the presence of anti-Ge antibodies and highlights the need for establishing a registry of rare blood groups antigens in Palestine.<\/jats:p>","DOI":"10.4103\/ajts.ajts_41_23","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:35:55Z","timestamp":1725014155000},"page":"354-357","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Molecular and clinical characterization of the first Palestinian case of anti-Gerbich"],"prefix":"10.4103","volume":"19","author":[{"given":"Alex","family":"Ballout","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaidon","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"},{"name":"Department of Molecular Genetics and Genetic Toxicology, Arab American University Palestine, Ramallah, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Hilo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlam","family":"Mujahed","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Juneidi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Saleh","sequence":"additional","affiliation":[{"name":"Specialized Child Care Center, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadra","family":"Salami","sequence":"additional","affiliation":[{"name":"Specialized Child Care Center, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Hindiyeh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Augusta Victoria Hospital, Jerusalem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"R1-20251022","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/bjh.14578","article-title":"Genetic background of the rare Yus and Gerbich blood group phenotypes:Homologous regions of the GYPC gene contribute to deletion alleles","volume":"177","author":"Gourri","year":"2017","journal-title":"Br J Haematol"},{"key":"R2-20251022","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tmrv.2018.02.004","article-title":"The Gerbich blood group system:Old knowledge, new importance","volume":"32","author":"Jaskiewicz","year":"2018","journal-title":"Transfus Med Rev"},{"key":"R3-20251022","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1365-3148.1997.d01-33.x","article-title":"A mutation analysis on GYPC, the gene encoding the Gerbich blood group antigens","volume":"7","author":"Johnson","year":"1997","journal-title":"Transfus Med"},{"key":"R4-20251022","doi-asserted-by":"crossref","first-page":"60","DOI":"10.21307\/immunohematology-2019-204","article-title":"The Gerbich blood group system:A review","volume":"26","author":"Walker","year":"2010","journal-title":"Immunohematology"},{"key":"R6-20251022","doi-asserted-by":"crossref","first-page":"64","DOI":"10.21307\/immunohematology-2019-348","article-title":"Rare blood donors:A personal approach","volume":"22","author":"Levene","year":"2006","journal-title":"Immunohematology"},{"key":"R8-20251022","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3349\/ymj.2018.59.10.1253","article-title":"Identification of anti-gerbich antibody in an Emirati marrow hematopoietic progenitor cell donor with Fy (a-b-) phenotype","volume":"59","author":"Choi","year":"2018","journal-title":"Yonsei Med J"},{"key":"R9-20251022","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/0973-6247.106758","article-title":"Antibodies against high frequency Gerbich 2 antigen (anti-Ge2):A real challenge in cross matching lab","volume":"7","author":"Singh","year":"2013","journal-title":"Asian J Transfus Sci"},{"key":"R10-20251022","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1537-2995.2008.02014.x","article-title":"The persistence and evanescence of blood group alloantibodies in men","volume":"49","author":"Tormey","year":"2009","journal-title":"Transfusion"}],"container-title":["Asian Journal of Transfusion 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History"}},{"value":"2023-04-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}