{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:25Z","timestamp":1786728625154,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Fresh frozen plasma (FFP) is frequently used as prophylactic hemostatic therapy for correction of periprocedural coagulopathy. This practice is frequently based on the assumption that deranged international normalized ratio (INR) predicts the risk of periprocedural bleeding and that FFP transfusion is effective in mitigating the procedure-associated bleeding risks. There is limited evidence to support both these assumptions in the context of image-guided drainage of infected collections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS:<\/jats:title>\n                    <jats:p>The study aimed to analyze the efficacy of weight-based standard FFP dose for correction of infection-associated coagulopathy in patients with clinicoradiologically diagnosed infected collections planned for image-guided drainage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>In this prospective case\u2013control study, 229 patients with clinicoradiologically diagnosed infected abdominal collection(s) planned to undergo image-guided drainage were included. Cases and controls were defined as patients with baseline INR &gt;1.2\u20133 (in the absence of any other bleeding diathesis) and INR \u22641.2, respectively. Cases received 10\u201315 mL\/kg of FFP before drainage. Costs and time delays in drainage among the two groups, efficacy of plasma transfusion in the correction of coagulopathy, incidence of transfusion reactions, bleeding complications, and inhospital mortality were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There were 117 cases and 112 controls. A total of 445 FFP units were utilized. The median (interquartile range) time required from diagnosis of collection to the procedure was 25.3 (20.8\u201340.3) hours among cases and 16.4 (8.7\u201320.1) hours among controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). FFP transfusion resulted in INR normalization (\u22641.2) only in 7.9% of cases (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9). Among the 81 cases who had pretransfusion INR \u22651.5, INR improved to \u22641.5 in 49 (60.4%) patients. There was an average of 2.9% decrease in INR per unit of FFP transfused. No bleeding complications were noted in patients undergoing drainage despite a persistent deranged INR (&gt;1.5) postplasma transfusion. Transfusion reactions occurred in 17\/117 (14.5%) patients. There were no deaths among the controls while five patients died among the cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Prophylactic FFP transfusion for infection-associated coagulopathy leads to a significant delay in lifesaving drainage procedures. Minority of patients attain normalization of INR with FFP transfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_55_23","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T01:00:55Z","timestamp":1707267655000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Futility of fresh frozen plasma in the correction of coagulopathy prior to image-guided drainage of infected collections: Results from a prospective case\u2013control study"],"prefix":"10.4103","volume":"20","author":[{"given":"Pradakshna","family":"Porchezhian","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, PGIMER, Chandigarh, India"},{"name":"Department of Endocrinology and Metabolism, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, PGIMER, Chandigarh, India"},{"name":"Department of Internal Medicine and Infectious Disease, Paras Hospital, Panchkula, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjawal","family":"Gorsi","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakhvinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hematology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Department of Hematology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arihant","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"R1-20260529","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1537-2995.2010.02798.x","article-title":"The use of fresh-frozen plasma in England: High levels of inappropriate use in adults and children","volume":"51","author":"Stanworth","year":"2011","journal-title":"Transfusion"},{"key":"R2-20260529","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/bjh.15167","article-title":"British society of haematology guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: Their handling and use in various patient groups in the absence of major bleeding","volume":"181","author":"Green","year":"2018","journal-title":"Br J Haematol"},{"key":"R3-20260529","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archsurg.1992.01420030035006","article-title":"Central venous catheterization in patients with coagulopathy","volume":"127","author":"Foster","year":"1992","journal-title":"Arch Surg"},{"key":"R4-20260529","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1378\/chest.110.1.185","article-title":"Central venous catheter placement in patients with disorders of hemostasis","volume":"110","author":"Doerfler","year":"1996","journal-title":"Chest"},{"key":"R5-20260529","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/BF01313579","article-title":"Bleeding after liver biopsy does not correlate with indices of peripheral coagulation","volume":"26","author":"Ewe","year":"1981","journal-title":"Dig Dis Sci"},{"key":"R6-20260529","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0140-6736(84)92910-6","article-title":"Percutaneous liver biopsy with plugging of needle track: A safe method for use in patients with impaired coagulation","volume":"2","author":"Riley","year":"1984","journal-title":"Lancet"},{"key":"R7-20260529","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1537-2995.2005.00546.x","article-title":"Transfusion Medicine\/Hemostasis Clinical Trials Network. 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