{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:22:59Z","timestamp":1787844179617,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract:<\/jats:title>\n \n BACKGROUND:<\/jats:title>\n Hypertriglyceridemia (HTG) is the third-most important cause of acute pancreatitis (AP) and its early diagnosis is essential to prevent AP-associated morbidity and mortality. Therapeutic plasma exchange (TPE) is a promising treatment option for improving patient outcomes and prognosis in HTG-induced AP (HTG-AP).<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n This study assessed the severity of disease in patients with HTG-AP and evaluated the therapeutic effects, safety, and procedural challenges of TPE in its management.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n Patients with HTG-AP, diagnosed according to the Atlanta classification, and exhibiting serum triglyceride (TG) concentrations \u226511.3 mmol\/L were included in the study. Consenting patients received TPE using the PRISMAFLEX\n \u00ae<\/jats:sup>\n system (TPE group), and the remaining were treated in accordance with the guidelines of Vietnam\u2019s Ministry of Health, 2015 (non-TPE group). The duration of hospital or intensive care unit (ICU) stay in patients and mortality rates were compared between the TPE and non-TPE groups. The reduction in serum TG levels was also evaluated in the TPE group.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n This prospective study included 165 patients with HTG-AP (\n n<\/jats:italic>\n = 83, TPE group;\n n<\/jats:italic>\n = 82, non-TPE group). The mean age of the patients was 41.0 \u00b1 9.3 years. The duration of hospital and ICU stay was significantly lower in the TPE group compared to that of the non-TPE group (\n P<\/jats:italic>\n < 0.05). A significant reduction in TG levels over baseline was noted in patients who received TPE (77%;\n P<\/jats:italic>\n < 0.05), which was observed after the first TPE session (70.81%;\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n TPE using the PRISMAFLEX\n \u00ae<\/jats:sup>\n system is safe and well-tolerated in patients with HTG-AP and is associated with minimal technical constraints.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ajts.ajts_67_21","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T13:52:48Z","timestamp":1664632368000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic plasma exchange for the management of hypertriglyceridemia-induced acute pancreatitis"],"prefix":"10.4103","volume":"20","author":[{"given":"Do Thanh","family":"Hoa","sequence":"first","affiliation":[{"name":"Emergency Department, 108 Military Central Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Gia","family":"Binh","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi Viet","family":"Hoa","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Tam Anh Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Hai","family":"Ghi","sequence":"additional","affiliation":[{"name":"Emergency Department, 108 Military Central Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Xuan","family":"Duong","sequence":"additional","affiliation":[{"name":"Emergency Department, 108 Military Central Hospital, Hanoi, 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