{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:41Z","timestamp":1787169701072,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I\/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determining the ability of cold agglutinins in inducing hemolysis such as antibody concentration and temperature. Here, we present a 54-year-old patient, a known case of chronic obstructive pulmonary disease who was admitted to our hospital in the winter months as a case of alcohol withdrawal syndrome. During the course of the stay, the patient developed respiratory insufficiency and went into Type II respiratory failure and hematological investigations revealed features of CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_78_20","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T10:40:33Z","timestamp":1636281633000},"page":"233-236","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Coomb's negative cold agglutinin disease"],"prefix":"10.4103","volume":"15","author":[{"given":"K. V. Vinu","family":"Balraam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Masood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesan","family":"Somasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20240830","first-page":"1812","article-title":"Relationships between the blood serum and the Body cells","volume":"50","author":"Landsteiner","year":"1903","journal-title":"Munch Med Wochenschr"},{"key":"R2-21-20240830","first-page":"86","article-title":"A study of an auto agglutinin occurring in a human serum","volume":"29","author":"Clough","year":"1918","journal-title":"Johns Hopkins Hosp Bull"},{"key":"R3-21-20240830","first-page":"27","article-title":"The cold hemagglutinin disease","volume":"3","author":"Schubothe","year":"1966","journal-title":"Semin Hematol"},{"key":"R6-21-20240830","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1752-1947-4-252","article-title":"Fatal cold agglutinin-induced haemolytic anaemia: A case report","volume":"4","author":"Lodi","year":"2010","journal-title":"Med Case Rep"},{"key":"R7-21-20240830","first-page":"1590","article-title":"About paroxysmal hemoglobinuria","volume":"51","author":"Donath","year":"1904","journal-title":"M\u00fcch Med Wschr"},{"key":"R9-21-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11613\/BM.2018.031001","article-title":"Effect of cold agglutinins on red blood cell parameters in a trauma patient: A case report","volume":"28","author":"Topic","year":"2018","journal-title":"Biochem Med"},{"key":"R10-21-20240830","first-page":"40","article-title":"Unexpected laboratory results in cold agglutinin disease","volume":"1","author":"Esra Yasar","year":"2018","journal-title":"Int J Med Biochem"},{"key":"R11-21-20240830","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5858\/arpa.2015-0444-RS","article-title":"The direct antiglobulin test: Indications, interpretation, and pitfalls","volume":"141","author":"Parker","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"R12-21-20240830","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/14767050600631757","article-title":"Autoimmune hemolytic anemia caused by cold agglutinins in a young pregnant woman","volume":"19","author":"Batalias","year":"2006","journal-title":"Matern Neonatal Med"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.AJTS_78_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:12:13Z","timestamp":1787166733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.AJTS_78_20"}},"subtitle":["A rare report of an incidentally detected case"],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_78_20","relation":{},"ISSN":["0973-6247"],"issn-type":[{"value":"0973-6247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}