{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:33:14Z","timestamp":1787758394638,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Hepcidin-25, a polypeptide hormone, plays a major role in iron metabolism and is found to be reduced during iron deficiency; therefore, testing for hepcidin can be utilized as an indicator of bioavailability of iron. Globally, reference range values for hepcidin have been established in different communities. The aim of the present study was to establish the normal reference range values of serum hepcidin in Indian blood donors to fathom the baseline and reference point of hepcidin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>A total of 90 donors fulfilling the eligibility criteria were recruited in the study consisting of 28 males and 62 females. Blood samples collected were used to execute hemoglobin (Hb), serum ferritin, and hepcidin assays. Serum hepcidin-25 isoform was detected by a commercial competitive enzyme-linked immunosorbent assay kit according to the manufacturer's instructions. Hb and ferritin were evaluated by the standard methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The mean \u00b1 standard deviation (SD) of Hb level in males was 14.62 \u00b1 1.34 g\/dL and females was 13.33 \u00b1 0.76 g\/dL. The mean \u00b1 SD of ferritin level in males was 113 \u00b1 56.12 ng\/mL and females was 62.65 \u00b1 40.8 ng\/mL. Similarly, the mean \u00b1 SD of hepcidin level in male donors was 22.18 \u00b1 12.17 ng\/mL and female donors was 10.95 \u00b1 6.06 ng\/mL. The established reference range values of Hepcidin were 6.32\u201346.06 ng\/mL for males and 3.44\u201324.78 for females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>These findings suggest that further studies with larger groups of donors are mandatory to produce reference values of hepcidin that can be pr\u00e9cised to the whole populace in India.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_7_22","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T04:48:23Z","timestamp":1664254103000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Establishment of normal reference range of serum hepcidin in Indian blood 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