{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:26:54Z","timestamp":1787776014631,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>ABO hemolytic disease of the fetus and newborn (HDFN) generally occurs due to transplacental passage of maternal IgG ABO antibodies causing fetal and newborn red cell hemolysis. Preterm, premature neonates born to O blood group mothers with a high titer of anti-A and\/or anti-B antibodies are more prone to developing ABO HDFN. This is a case of ABO HDFN in a preterm, premature, and low birth weight B-positive baby of an O-positive, HbE-beta thalassemic mother. The mother had a very high titer of anti-B antibodies, leading to ABO HDFN. The mother was also allo-immunized with anti-Jk (a) antibodies from past packed red blood cell (PRBC) transfusions she received for thalassemia. This anti-Jk (a) antibody was not detected in the antenatal period, probably due to the low titer of the antibody. The mother had an anamnestic response to the PRBCs provided in the antenatal period, and thus, the anti-Jk (a) became identifiable during the pretransfusion workup for the baby. Even if the baby was Jk (a) antigen positive, the baby developed HDFN mostly due to ABO incompatibility. The baby was managed with a double-volume exchange transfusion with reconstituted whole blood and phototherapy. During the postnatal period, the mother developed a delayed hemolytic transfusion reaction (DHTR) due to the anti-Jk (a) antibodies, as she had received Jk (a) antigen-positive PRBC transfusions in the antenatal period. Later, the mother responded well to the Jk (a) antigen-negative PRBC transfusions and conservative management for the DHTR.<\/jats:p>","DOI":"10.4103\/ajts.ajts_7_24","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:33:28Z","timestamp":1725014008000},"page":"381-385","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling complexity: A case report on ABO hemolytic disease of the fetus newborn in a preterm neonate and delayed hemolytic transfusion reaction in the beta thalassemic mother due to alloanti kidd a antibody"],"prefix":"10.4103","volume":"19","author":[{"given":"V. K.","family":"Nayana","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somnath","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansuman","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Stephy","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"R1-20251022","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12288-017-0792-1","article-title":"ABO hemolytic disease of fetus and newborn;still a diagnostic dilemma:A case report","volume":"34","author":"Kumawat","year":"2018","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R2-20251022","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12288-012-0202-7","article-title":"Hemolytic disease of the newborn due to anti-jkb:Case report and review of the literature","volume":"30","author":"Velasco","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R3-20251022","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4103\/ajts.AJTS_106_17","article-title":"Severe ABO hemolytic disease of fetus and newborn requiring blood exchange transfusion","volume":"12","author":"Jain","year":"2018","journal-title":"Asian J Transfus Sci"},{"key":"R4-20251022","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1136\/fn.88.6.F455","article-title":"Jaundice in low birthweight infants:Pathobiology and outcome","volume":"88","author":"Watchko","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"R5-20251022","first-page":"522","article-title":"Hb E\/beta-thalassaemia:A common and clinically diverse disorder","volume":"134","author":"Olivieri","year":"2011","journal-title":"Indian J Med Res"},{"key":"R6-20251022","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/IJWH.S89308","article-title":"Pregnancy in women with thalassemia:Challenges and solutions","volume":"8","author":"Petrakos","year":"2016","journal-title":"Int J Womens Health"},{"key":"R7-20251022","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1182\/blood-2018-08-833962","article-title":"Transfusion-related red blood cell alloantibodies:Induction and consequences","volume":"133","author":"Tormey","year":"2019","journal-title":"Blood"},{"key":"R8-20251022","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1046\/j.1537-2995.2000.40080936.x","article-title":"Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions","volume":"40","author":"Rozman","year":"2000","journal-title":"Transfusion"},{"key":"R9-20251022","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.transci.2008.07.007","article-title":"Haemolytic disease of fetus and newborn caused by ABO antibodies in a cisAB offspring","volume":"39","author":"Deng","year":"2008","journal-title":"Transfus Apher Sci"},{"key":"R11-20251022","first-page":"319","article-title":"Neonatal jaundice","volume":"2011","author":"Woodgate","year":"2011","journal-title":"BMJ Clin Evid"},{"key":"R12-20251022","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/vox.13327","article-title":"The spectrum of ABO haemolytic disease of the fetus and newborn in neonates born to group O mothers","volume":"117","author":"Talwar","year":"2022","journal-title":"Vox Sang"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_7_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:47:57Z","timestamp":1787773677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_7_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_7_24","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"2024-01-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}