{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:41:04Z","timestamp":1792291264064,"version":"4.4.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Macrothrombocytopenia is a combination of thrombocytopenia and giant platelets (PLTs). It can be found asymptomatically with several genetic polymorphisms\/mutations. This study aimed to assess the prevalence of macrothrombocytopenia in blood donors and to identify its geographic variation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      A cross-sectional observational study was conducted in blood donors in the East, West, North, and South zones of India. Donors not eligible for blood donation were excluded. Blood was collected and analyzed by hematology analyzer. Samples with low PLT count (&lt;1.5 lakhs\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) and mean PLT volume &gt;11.5 fl were identified, and a peripheral blood smear was prepared, stained, and screened for giant PLTs. The data were analyzed using MS Excel (Microsoft 365), RStudio (Version: 2023.03.1 + 446), and IBM SPSS Statistics 27.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 2574 donors were screened at four centers of different geographic zones of India. The mean age was 34.81 \u00b1 9.32 with male: female of 34.75:1. Overall macrothrombocytopenia was found in 102 (4%) with significant zonal variation: 88 (86.3%), 4 (3.9%) in East and South, respectively, and 5 (4.9%) each in West and North regions. The peripheral smears revealed giant PLTs in all cases of macrothrombocytopenia in the South and North, 76% and 80% in the East and West, respectively. The most common blood group showing macrothrombocytopenia was B positive 41 (40.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Macrothrombocytopenia shows significant zonal variation, with a maximum number of cases identified in the East zone of India. Screening and awareness of this condition are essential to counsel donors for bleeding tendencies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_89_24","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T12:07:26Z","timestamp":1751371646000},"page":"6-10","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of asymptomatic macrothrombocytopenia in voluntary blood donors: A multicentric study"],"prefix":"10.4103","volume":"19","author":[{"given":"Archana","family":"Buch","sequence":"first","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaminy","family":"Ingale","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulika","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Apollo Hospital Hyderabad, South Zone, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta Sekhar","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charusheela","family":"Gore","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Central Research Facility, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0002-9343(02)01114-2","article-title":"Asymptomatic constitutional macrothrombocytopenia among West Bengal blood donors","volume":"112","author":"Naina","year":"2002","journal-title":"Am J Med"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12288-018-0950-0","article-title":"Inherited macrothrombocytopenia: Correlating morphology, epidemiology, molecular pathology and clinical features","volume":"34","author":"Ghosh","year":"2018","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R3-20260422","first-page":"e16964","article-title":"Myosin heavy chain 9 (MYH9)-related congenital 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men","volume":"118","author":"Butkiewicz","year":"2006","journal-title":"Thromb Res"},{"key":"R11-20260422","first-page":"C01","article-title":"Giant platelets in platelet donors \u2013 A blessing in disguise?","volume":"9","author":"Roy","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"R12-20260422","first-page":"11","article-title":"Harris platelet syndrome: The need to recognise the entity","volume":"4","author":"Choccalingam","year":"2013","journal-title":"J Med Health Sci"},{"key":"R13-20260422","doi-asserted-by":"crossref","first-page":"1391742","DOI":"10.3389\/fped.2024.1391742","article-title":"Case report: MYH9-related disease caused by Ala44Pro mutation in a child with a previous diagnosis of chronic immune thrombocytopenia","volume":"12","author":"Niwa","year":"2024","journal-title":"Front Pediatr"},{"key":"R14-20260422","doi-asserted-by":"crossref","first-page":"372","DOI":"10.17511\/ijmrr.2016.i03.15","article-title":"Distribution of ABO blood groups and Rh (D) factor in and around Anatapuramu, Andhra Pradesh","volume":"4","author":"Bhavani","year":"2016","journal-title":"Int J Med Res Rev"},{"key":"R15-20260422","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/09537101003615402","article-title":"Platelet and red blood cell indices in Harris platelet syndrome","volume":"21","author":"Naina","year":"2010","journal-title":"Platelets"}],"container-title":["Asian Journal of Transfusion 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