{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:50:08Z","timestamp":1792702208086,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Therapeutic plasma exchange (TPE) is commonly used as a treatment modality in varying neurological disorders. Response to TPE in neurological disorders is usually noted in \u201csubjective\u201d terms. We, measured response to treatment, objectively, using Modified Rankin Scale (MRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>This was an observational prospective study in patients diagnosed with autoimmune neurological disorders (AND) who underwent TPE, in addition to intravenous immunoglobulin, and\/or prednisolone. This study was carried out at a tertiary care center. Demographic data, procedure details including adverse reactions, and clinical responses were collated. Clinical response was assessed by applying MRS, in different neurological disorders, before (pre-TPE) and after TPE (post-TPE). Pre- and post-TPE clinical conditions were compared using the Wilcoxon matched-pairs signed-ranks test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Fifty-three patients were included, with 15 females and 38 males, who had a median age of 48 years. Seven different AND were; myasthenia gravis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11), Guillain\u2013Barre syndrome (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18), neuromyelitis Optica spectrum disorders (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6); chronic inflammatory demyelinating polyneuropathy (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5); autoimmune encephalitis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6); transverse myelitis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6); and multiple sclerosis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1). Patients received a median of 5 cycles of TPE and a mean 1.5 plasma volume was exchanged. The improvement in the MRS scale was significant when post-TPE scores were compared with pre-TPE scores. The most common adverse reaction was shivering (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5; 1.85%), which was managed conservatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>TPE was shown to be an effective and safe treatment modality in providing relief to patients with neurological disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_90_24","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T04:00:17Z","timestamp":1737691217000},"page":"187-192","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and safety of therapeutic plasma exchange in neurological disorders; measuring the response to treatment using Modified Rankin Scale \u2013 A single-center study"],"prefix":"10.4103","volume":"19","author":[{"given":"Shubham","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem Kumar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geet","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samruddhi","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Medanta-The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Medanta-The Medicity, Gurugram, Haryana, 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