{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:31:52Z","timestamp":1787772712994,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Melanotic neuroectodermal tumour of infancy (MNTI) is an unusual, rapid growing, pigmented tumour of neural crestal origin that is seen in infants. It is more common in males with predilection for the maxilla and an unpredictable malignant potential. It constitutes a great challenge in diagnosis, treatment planning and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Concerns:<\/jats:title>\n                    <jats:p>This is a case of MTNI in a 5-month-old female child, who presented to the Department of Oral and Maxillofacial Surgery with progressive swelling on the right side of the upper jaw over the last two weeks with \u2018teeth floating appearance on imaging\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis:<\/jats:title>\n                    <jats:p>There was significant extraoral diffuse swelling and facial asymmetry. Intraorally a well-defined mass noted on alveolar ridge of anterior maxilla and hard palate, crossing midline and associated with unerupted teeth. A subsequent contrast-enhanced computed tomography (CECT) scan and 3D CT scan revealed an expansile radiolucent lesion involving the right maxilla with destruction of cortical bone and displacement of primary central, lateral, canine and molar teeth, which appeared as a \u2018free-floating teeth appearance\u2019 in axial and coronal sections, confirmed by an open biopsy as Melanotic neuro-ectodermal tumour of infancy. Immunohistochemistry was used for precise diagnosis due to biopsy sample limitations and tumour variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Surgical resection was done after obtaining informed consent from the parents under general anaesthesia. The removal of unerupted primary central and lateral incisors, canine and molar teeth and also peripheral ostectomy was done as visible flecks were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome:<\/jats:title>\n                    <jats:p>The postoperative period was uneventful. Regular follow-up after 26 months postoperatively showed acceptable healing with no portent of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Take-away Lessons:<\/jats:title>\n                    <jats:p>Early diagnosis and conservative surgical treatment and periodic follow-up postoperatively gives an excellent result with good prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ams.ams_120_24","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T12:01:45Z","timestamp":1736424105000},"page":"244-247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Melanocytic Neuroectodermal Tumour of Infancy-A Rare Case Report"],"prefix":"10.4103","volume":"14","author":[{"given":"Ratna Kumari","family":"Beeram","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mamata Dental College and Hospital, Karimnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busa","family":"Vamshidhar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Prathima Institute of Medical Sciences, Karimnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareen","family":"Seelam","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mamata Dental College and Hospital, Karimnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotya Naik","family":"Maloth","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Mamata Dental College and Hospital, Karimnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kundoor Vinay Kumar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Mamata Dental College and Hospital, Karimnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moni","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Mamata Dental College and Hospital, Karimnagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"R1-20250109","article-title":"Melanotic neuroectodermal tumor of infancy: A case report and literature review","author":"Balakrishnan","year":"2023","journal-title":"South Asian J Cancer"},{"key":"R2-20250109","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/1097-0142(196602)19:2<196::AID-CNCR2820190210>3.0.CO;2-6","article-title":"Melanotic neuroectodermal tumor of infancy- a neoplasm of neural crese origin. Report of a case associated with high urinary excretion of vanilmandelic acid","volume":"19","author":"Borello","year":"1966","journal-title":"Cancer"},{"key":"R3-20250109","doi-asserted-by":"crossref","first-page":"26","DOI":"10.26444\/jpccr\/134178","article-title":"Melanotic neuroectodermal tumor of infancy. Case report","volume":"15","author":"Haberko","year":"2021","journal-title":"Journal of Pre-Clinical and Clinical Research"},{"key":"R4-20250109","first-page":"111","article-title":"Paediatric jaw tumours: Experiences and findings from a resource limited tertiary health care center","volume":"36","author":"Akhiwu","year":"2020","journal-title":"Pan Afr Med J"},{"key":"R5-20250109","first-page":"1","article-title":"Focus on melanotic neuroectodermal tumor of infancy","volume":"3","author":"Krawczyk","year":"2024","journal-title":"EJC Paediatr Oncol"},{"key":"R6-20250109","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/ams.ams_5_22","article-title":"Melanotic neuroectodermal tumour of infancy \u2013A case report and review of literature","volume":"12","author":"Jakka","year":"2022","journal-title":"Ann Maxillofac Surg"},{"key":"R7-20250109","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00381-020-04509-6","article-title":"Melanotic neuroectodermal tumor of infancy to the skull: Case-based review","volume":"36","author":"Ebel","year":"2020","journal-title":"Childs Nerv Syst"},{"key":"R8-20250109","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.4103\/ijmpo.ijmpo_256_17","article-title":"An alternate method of fabrication of an obturator in a patient diagnosed with melanotic neuroectodermal tumor of infancy","volume":"40","author":"Dholam","year":"2019","journal-title":"Indian J Med Paediatr Oncol"},{"key":"R9-20250109","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.wneu.2019.07.017","article-title":"Melanotic neuroectodermal tumor of infancy arising in the skull and brain: A systematic review","volume":"130","author":"Ren","year":"2019","journal-title":"World Neurosurg"},{"key":"R10-20250109","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jobcr.2023.03.005","article-title":"Long term follow-up results of enucleation as the definitive treatment for melanocytic neuroectodermal tumour of infancy and a review on its treatment","volume":"13","author":"Dekyi","year":"2023","journal-title":"J Oral Biol Craniofac Res"}],"container-title":["Annals of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ams.ams_120_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:08Z","timestamp":1787771408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ams.ams_120_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ams.ams_120_24","relation":{},"ISSN":["2231-0746","2249-3816"],"issn-type":[{"value":"2231-0746","type":"print"},{"value":"2249-3816","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-06-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}