{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:03:32Z","timestamp":1790107412237,"version":"4.0.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Central giant cell granuloma (CGCG) is a non-neoplastic proliferative lesion that clinically and radiologically mimics various lesions without any unique pathognomic features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Concerns:<\/jats:title>\n                    <jats:p>A 14-year-old male patient reported with a chief complaint of swelling in the right upper back tooth region for four months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis:<\/jats:title>\n                    <jats:p>Incisional biopsy of the lesion shows numerous dilated and thin-walled blood vessels and focal areas of chronic inflammatory cell infiltrate beneath the epithelium suggestive of angiofibroma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Treatment:<\/jats:title>\n                    <jats:p>Surgical excision of the lesion along with curettage was done under general anaesthesia. On histopathologic examination, the lesion revealed loose connective tissue stroma with mesenchymal cells and multinucleated giant cells suggestive of CGCG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>The patient was followed up for one year without any evidence of recurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Take-away Lessons:<\/jats:title>\n                    <jats:p>Presentation of CGCG of the oral cavity is rare and mimics a wide variety of lesions clinically and radiologically. Histopathology remains the only diagnostic modality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ams.ams_130_24","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:00:14Z","timestamp":1742274014000},"page":"95-97","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Central Giant Cell Granuloma of Posterior Maxilla - A Case Report"],"prefix":"10.4103","volume":"15","author":[{"given":"M.","family":"Madhuvandhi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha","family":"Asokan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Duraimurugan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"R1-20250710","doi-asserted-by":"crossref","first-page":"20200429","DOI":"10.1259\/dmfr.20200429","article-title":"Radiological features of central giant cell granuloma: Comparative study of 7 cases and literature review","volume":"50","author":"Shrestha","year":"2021","journal-title":"Dentomaxillofac Radiol"},{"key":"R2-20250710","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s12070-021-02794-4","article-title":"Central giant cell granuloma of maxilla: A case report","volume":"74","author":"Patel","year":"2022","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"R3-20250710","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5624\/isd.20220130","article-title":"Cone-beam computed tomographic imaging of central giant cell granuloma: A comprehensive review","volume":"52","author":"Tahmasbi-Arashlow","year":"2022","journal-title":"Imaging Sci Dent"},{"key":"R4-20250710","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12070-012-0538-1","article-title":"Central giant cell granuloma of maxilla: A case report","volume":"65","author":"Padmavathi","year":"2013","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"R5-20250710","first-page":"130","article-title":"Central giant cell granuloma \u2013A case report","volume":"30","author":"Balaji","year":"2019","journal-title":"Indian J Dent Res"},{"key":"R6-20250710","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-009903","article-title":"Central giant cell granuloma: A case report","author":"Mohan","year":"2013","journal-title":"BMJ Case Rep 2013"},{"key":"R7-20250710","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4103\/jomfp.jomfp_487_20","article-title":"Central giant cell granuloma \u2013An update","volume":"24","author":"Ramesh","year":"2020","journal-title":"J Oral Maxillofac Pathol"},{"key":"R8-20250710","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.joms.2020.03.034","article-title":"Mandibular intraosseous angiofibroma-a rare clinical entity","volume":"78","author":"Amini-Salari","year":"2020","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Annals of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ams.ams_130_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:39Z","timestamp":1787067699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ams.ams_130_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ams.ams_130_24","relation":{},"ISSN":["2231-0746","2249-3816"],"issn-type":[{"value":"2231-0746","type":"print"},{"value":"2249-3816","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}