{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:56Z","timestamp":1786649396639,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Dental anxiety has a major impact on patient compliance, which frequently requires pre-operative pharmacological intervention. Although commonly utilised, melatonin, an endogenous hormone with analgesic and anxiolytic effects and alprazolam, a short-acting benzodiazepine, are not frequently compared in minor oral surgical procedures. This study compares melatonin and alprazolam as anxiolytic and analgesic agents in patients undergoing minor oral surgical procedures.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In a triple-blind, randomised controlled trial, 42 American Society of Anesthesiologists (ASA) I\/II patients (ages 20\u201350) with pre-operative anxiety (visual analogue scale [VAS] >50) were randomly assigned to either oral melatonin 3 mg (Group A) or oral alprazolam 0.5 mg (Group B) one hour prior to surgery. Pre-, intra- and postoperatively, anxiety (VAS, Trail Making Test), sedation (Ramsay Sedation Scale) and recovery (Modified Aldrete Score) were evaluated. The Mann\u2013Whitney\n U<\/jats:italic>\n and Wilcoxon signed-rank tests (SPSS v25) were used for statistical analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Both groups showed a significant intra-group decrease in VAS anxiety scores (\n P<\/jats:italic>\n < 0.001). A post-operative inter-group comparison showed that melatonin provided superior anxiolysis (\n P<\/jats:italic>\n = 0.03) and less sedation (\n P<\/jats:italic>\n = 0.01). The modified Aldrete scores were similar (\n P<\/jats:italic>\n = 1.00), and no negative effects were noted.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Although both treatments are successful in lowering perioperative anxiety, melatonin\u2019s superior anxiolytic effects and a positive sedation-recovery profile make it a potential substitute for benzodiazepines in minor oral surgical operations.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ams.ams_138_25","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:00:10Z","timestamp":1766397610000},"page":"143-148","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin and Alprazolam as Anxiolytic Agents in Minor Oral Surgical Procedures \u2013 A Comparative Study"],"prefix":"10.4103","volume":"15","author":[{"given":"Sree Sai Akhila","family":"Garikipati","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Satish","family":"Pratigudupu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Jasline","family":"David","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas Chakravarthi","family":"Pandi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya Sagar","family":"Badugu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja Sree","family":"Chunduru","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, 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