{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:35Z","timestamp":1787762015065,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"Abstract<\/jats:title>\n \n Rationale:<\/jats:title>\n Submandibular gland epidermoid cyst is extremely rare and malignant transformation into squamous cell carcinoma (SCC) is even rarer. No such case report is published.<\/jats:p>\n <\/jats:sec>\n \n Patient Concerns:<\/jats:title>\n A 49-year-old female reported with a large, slowly growing left-sided neck swelling present for two years. Her primary concern was large swelling.<\/jats:p>\n <\/jats:sec>\n \n Diagnosis:<\/jats:title>\n Clinical finding, cytology and imaging were suggestive of \u2018Epidermoid Cyst of Submandibular Gland\u2019. Intraoperative frozen section and post-operative definitive histopathological examination (HPE) revealed malignant transformation into SCC.<\/jats:p>\n <\/jats:sec>\n \n Treatment:<\/jats:title>\n In toto surgical excision was performed. Once the frozen section HPE confirmed transformation into SCC, clearance of 4\u20136 mm margin and modified supraomohyoid neck dissection was completed.<\/jats:p>\n <\/jats:sec>\n \n Outcome:<\/jats:title>\n No sign of recurrence on 1-year postoperative follow-up.<\/jats:p>\n <\/jats:sec>\n \n Take-Away Lesson:<\/jats:title>\n This case is unique of its kind without any previous literature report. In case of large and rapidly growing submandibular gland lesion, possibility of malignant transformation should not be overruled.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ams.ams_167_22","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T12:18:37Z","timestamp":1686053917000},"page":"98-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Challenges in a Rare Submandibular Epidermoid Cyst Transforming into Squamous Cell Carcinoma - A Case Report"],"prefix":"10.4103","volume":"13","author":[{"given":"Ikbal","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Army Dental Corps, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/0976-237X.132376","article-title":"Unusually large submandibular epidermoid cyst: A case report, differential diagnosis and therapy","volume":"5","author":"Passi","year":"2014","journal-title":"Contemp Clin Dent"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4103\/0973-029X.102511","article-title":"Epidermoid cyst of submandibular region","volume":"16","author":"Janarthanam","year":"2012","journal-title":"J Oral Maxillofac Pathol"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000487794","article-title":"Incidental squamous cell carcinoma in an epidermal inclusion cyst: A case report and review of the literature","volume":"10","author":"Frank","year":"2018","journal-title":"Case Rep Dermatol"},{"key":"R4-20240828","first-page":"688","article-title":"Squamous cell carcinoma arising in an epidermal inclusion cyst","volume":"35","author":"Alkul","year":"2022","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"R5-20240828","first-page":"46","article-title":"Squamous cell carcinoma arising from an epidermal inclusion cyst: A case report","volume":"2","author":"Ziadi","year":"2010","journal-title":"N Am J Med Sci"},{"key":"R6-20240828","first-page":"2013","article-title":"An unusal case of epidermal cyst in submandibular space","volume":"3","author":"Kar","year":"2014","journal-title":"Int J Otolaryngol Head Neck Surg"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.12659\/AJCR.912828","article-title":"A rare transformation of epidermoid cyst into squamous cell carcinoma: A case report with literature review","volume":"20","author":"Faltaous","year":"2019","journal-title":"Am J Case Rep"},{"key":"R8-20240828","doi-asserted-by":"crossref","first-page":"114","DOI":"10.14730\/aaps.2020.02138","article-title":"Squamous cell carcinoma arising from a long-standing epidermoid cyst of the back","volume":"26","author":"Kim","year":"2020","journal-title":"Arch Aesthetic Plast Surg"},{"key":"R9-20240828","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bjoms.2008.03.006","article-title":"Squamous cell carcinoma arising in the lining of an epidermoid cyst within the sublingual gland \u2013 A case report","volume":"46","author":"Bhatt","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1053\/j.jfas.2017.09.005","article-title":"A rare presentation of a giant epidermoid inclusion cyst mimicking malignancy","volume":"57","author":"Paparella","year":"2018","journal-title":"J Foot Ankle Surg"}],"container-title":["Annals of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ams.ams_167_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:11:25Z","timestamp":1787760685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ams.ams_167_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ams.ams_167_22","relation":{},"ISSN":["2231-0746","2249-3816"],"issn-type":[{"value":"2231-0746","type":"print"},{"value":"2249-3816","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-09-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}