{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:37:53Z","timestamp":1787841473847,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Maxillofacial metastases from distant primary sites account for less than 1% of cancer in the head-and-neck region and are often misdiagnosed as benign or inflammatory conditions. The purpose of this study was to describe the clinical characteristics of patients with maxillofacial metastases, treatment and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Subjects with head-and-neck cancer were identified from the institutional database. Descriptive statistics were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 532 patients with head-and-neck cancer between 2008 and 2020, 15 (2.8%) had histologically verified metastatic lesions, of which 53.33% males with a mean age of 69 years. The median time from symptom onset to diagnosis was 17 days (range: 7\u201360). The mandible was the most common location (40%), followed by the parotid gland (33.33%) and maxilla (13.33%). Adenocarcinoma was the most frequent histology (60%), and half of the patients had extraoral manifestations. Tumour origin was gastrointestinal, lung (33.33% each), prostate (20%) and breast (13.3%). No predilection for tumour type or histology and location were seen. Radiographic features were non-specific, with computed tomography (CT) demonstrating periosteal reaction, bone expansion and lytic lesions and high variability in Positron Emission Tomography (PET) standardised uptake value (minimum: 2.0, maximum: 10.93 and mean: 4.14). Diagnosis led to altered treatment in 60%, more in extraoral than intraoral manifestations (71% vs. 37.5%); 40% received radiotherapy, 20% systemic treatment and none underwent surgery. Over half of the patients passed away within 6 months, median survival was 5 months, shorter in patients with intraoral than extraoral disease (3 vs. 13.2 months,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Maxillofacial metastases have elusive manifestations and often warrant specific treatment. Prospective data should evaluate associations between timely diagnosis and symptomatic improvement and survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ams.ams_183_23","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:00:40Z","timestamp":1721386840000},"page":"66-70","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Early Diagnosis of Maxillofacial Metastases on Treatment and Patient Outcomes - A Retrospective Study"],"prefix":"10.4103","volume":"14","author":[{"given":"Shahar","family":"Turgeman","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilit","family":"Turgeman","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Center, Emek Medical Center, Afula, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omri","family":"Emodi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel"},{"name":"Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Rachmiel","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel"},{"name":"Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s12105-022-01451-8","article-title":"Metastatic tumors to the oral soft tissues and jawbones: A retrospective analysis of 40 cases and review of the literature","volume":"16","author":"Ho","year":"2022","journal-title":"Head Neck Pathol"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"e573","DOI":"10.4317\/jced.59554","article-title":"Jaw bone metastasis from lung cancer as sole primary source: A systematic review","volume":"14","author":"Gupta","year":"2022","journal-title":"J Clin Exp Dent"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"101330","DOI":"10.1016\/j.jormas.2022.11.006","article-title":"Metastasis of malignant tumors to the oral cavity: Systematic review of case reports and case series","volume":"124","author":"Lopes","year":"2023","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"151448","DOI":"10.1016\/j.acthis.2019.151448","article-title":"Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations","volume":"121","author":"Kaplan","year":"2019","journal-title":"Acta Histochem"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"e474","DOI":"10.1016\/j.jormas.2021.12.009","article-title":"Metastasis to the oral and maxillofacial region. 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