{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:02Z","timestamp":1786649522144,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>This case report describes Landau\u2013Kleffner syndrome (LKS) with adult-onset epilepsy in a 33-year-old man with preexisting developmental delay. We outline the clinical presentation, including language regression and seizures, and address the diagnostic challenges. The case highlights the importance of considering LKS in case of adult-onset epilepsy and underscores the critical role of electroencephalography, particularly the presence of continuous spike-wave activity during sleep. We also review the treatment options of LKS with adult-onset epilepsy, with the focus on the effectiveness of levetiracetam. An atypical finding of right hippocampal sclerosis on brain magnetic resonance imaging is also noted. This case contributes to the limited literature on LKS with adult-onset epilepsy and emphasizes the need for further research.<\/jats:p>","DOI":"10.4103\/ant.ant-d-24-00039","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T21:00:07Z","timestamp":1777150807000},"page":"104-107","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Landau\u2013Kleffner Syndrome with Adult-onset Epilepsy: A Case Report"],"prefix":"10.4103","volume":"35","author":[{"given":"Chien-Ya","family":"Hsu","sequence":"first","affiliation":[{"name":"Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/epi.17241","article-title":"International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions","volume":"63","author":"Specchio","year":"2022","journal-title":"Epilepsia"},{"key":"R2-20260427","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1212\/WNL.7.8.523","article-title":"Syndrome of acquired aphasia with convulsive disorder in children","volume":"7","author":"Landau","year":"1957","journal-title":"Neurology"},{"key":"R3-20260427","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1708712","article-title":"Antibody-mediated encephalitis","volume":"378","author":"Dalmau","year":"2018","journal-title":"N Engl J Med"},{"key":"R4-20260427","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/ng.2728","article-title":"Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes","volume":"45","author":"Lemke","year":"2013","journal-title":"Nat Genet"},{"key":"R5-20260427","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ng.2726","article-title":"GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction","volume":"45","author":"Lesca","year":"2013","journal-title":"Nat Genet"},{"key":"R6-20260427","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1212\/01.WNL.0000140703.63270.9D","article-title":"Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome","volume":"63","author":"Takeoka","year":"2004","journal-title":"Neurology"},{"key":"R7-20260427","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.seizure.2013.09.016","article-title":"Landau-Kleffner syndrome: A study of 29 patients","volume":"23","author":"Caraballo","year":"2014","journal-title":"Seizure"},{"key":"R8-20260427","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.eplepsyres.2013.02.010","article-title":"Encephalopathy with status epilepticus during sleep or continuous spikes and waves during slow sleep syndrome: A multicenter, long-term follow-up study of 117 patients","volume":"105","author":"Caraballo","year":"2013","journal-title":"Epilepsy Res"},{"issue":"Suppl 7","key":"R9-20260427","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1528-1167.2009.02221.x","article-title":"Landau-Kleffner syndrome and CSWS syndrome: Treatment with intravenous immunoglobulins","volume":"50","author":"Arts","year":"2009","journal-title":"Epilepsia"}],"container-title":["Acta Neurologica Taiwanica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ant.ANT-D-24-00039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:58Z","timestamp":1786647298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ant.ANT-D-24-00039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ant.ant-d-24-00039","relation":{},"ISSN":["1028-768X","3050-9173"],"issn-type":[{"value":"1028-768X","type":"print"},{"value":"3050-9173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2024-10-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}