{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:45Z","timestamp":1787840805321,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bronchopulmonary dysplasia (BPD) poses a challenge in neonatal care. Previous literature recommended a hypothetical role for patent ductus arteriosus (PDA) in the development of BPD. This study explores the possible link between PDA and BPD, aiming to illuminate demographic and clinical factors influencing BPD development within the context of PDA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort analysis employed data from the National Inpatient Sample (NIS) spanning from 2016 to 2020. The study focused on patients diagnosed with PDA and BPD, identified through International Classification of Diseases 10\n                      <jats:sup>th<\/jats:sup>\n                      Revision codes Q250 and P271, respectively. Utilizing STATA \u00d715, descriptive and inferential statistics, encompassing univariate and multivariate regression analyses, were conducted to examine the association between PDA and BPD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 9737 patients were included: 5133 without PDA and 4604 with PDA. The mortality rate was significantly higher among patients with PDA (3.80%) compared to those without PDA (2.53%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Univariate and multivariate regression analyses identified a significant association between PDA and BPD, with odds ratios of 14.62 and 2.43, respectively (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). BPD patients with PDA also exhibited a significantly higher prevalence of extremely preterm birth (76.24% vs. 58.31%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) and extremely low birth weight (65.57% vs. 42.70%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) compared to BPD patients without PDA. In addition, significant associations were observed between BPD and factors such as preterm birth category, neonatal sepsis, race, hospital status, and region (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This research confirms the connection between PDA and BPD, stressing the importance of continued investigation and prospective studies. The findings highlight the need to consider several factors in understanding the etiology of the disease, which could lead to more targeted interventions and improved patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_118_24","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:00:24Z","timestamp":1731664824000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample"],"prefix":"10.4103","volume":"17","author":[{"given":"Kirellos Said","family":"Abbas","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Al-Matary","sequence":"additional","affiliation":[{"name":"Department of Neonatology, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan","family":"Elabd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Fouad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Badreldin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhannad","family":"Sharara","sequence":"additional","affiliation":[{"name":"Georgia Cancer Center, Augusta University, Augusta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa","family":"Elsebey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Florida, Pensacola, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Dobs","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan I.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institute, University of Minnesota, St Cloud, Minnesota, USA"},{"name":"Department of Neurology, University of Missouri, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rahman","family":"Adi","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrah","family":"Ghawi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Fahad Central Hospital, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadeer Ghazi","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda Yahya","family":"Alyahyawi","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlam","family":"Mazi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem Abdullah","family":"Alyoubi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"R1-20250107","first-page":"1822","article-title":"Comprehensive analysis of risk factors for bronchopulmonary dysplasia in preterm infants in Taiwan:A four-year study","volume":"10","author":"Huang","year":"2023","journal-title":"Children (Basel)"},{"key":"R2-20250107","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"key":"R3-20250107","doi-asserted-by":"crossref","first-page":"e2345299","DOI":"10.1001\/jamanetworkopen.2023.45299","article-title":"Patent Ductus arteriosus and 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dysplasia?","volume":"47","author":"Clyman","year":"2023","journal-title":"Semin Perinatol"},{"key":"R17-20250107","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1542\/peds.2007-2051","article-title":"Ibuprofen-induced patent ductus arteriosus closure:Physiologic, histologic, and biochemical effects on the premature lung","volume":"121","author":"McCurnin","year":"2008","journal-title":"Pediatrics"},{"key":"R18-20250107","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/s41372-020-0718-x","article-title":"The effect of prolonged tracheal intubation on the association between patent ductus arteriosus and bronchopulmonary dysplasia (grades 2 and 3)","volume":"40","author":"Clyman","year":"2020","journal-title":"J Perinatol"},{"key":"R19-20250107","doi-asserted-by":"crossref","first-page":"113712","DOI":"10.1016\/j.jpeds.2023.113712","article-title":"Current trends in invasive closure of patent ductus arteriosus in very low birth weight infants in United States 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