{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:01:27Z","timestamp":1788318087885,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mitral valve prolapse (MVP) is a common valvular disease in children. Symptoms in children with MVP are not explained by the severity of mitral regurgitation alone. Hence, we sought to correlate symptom status with the incidence of anxiety disorder in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Groups were as follows: (a) MVP;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 115; mean age: 13.5 \u00b1 3.06 years and (b) control;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 53; mean age: 15.1 \u00b1 13.2. The Screen for Child Anxiety-Related Emotional Disorders (SCAREDs) scale was filled by all participants. The SCARED scores of 25 and above determined a warning for anxiety disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean SCARED scale values of MVP and control groups were 29.2 \u00b1 13.08 and 24.9 \u00b1 14.17, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.065). Although the SCARED scale score was higher among the MVP patients, no significant difference was found between the groups in terms of the mean SCARED score, or the number of participants with a score of 25 or more. While girls with MVP had higher anxiety scores compared to boys with the disorder, there was no difference with respect to SCARED scores in children with MVP and the general population when analyzed separately by gender. Moreover, the SCARED scale score was significantly higher in symptomatic MVP patients than in asymptomatic cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Children with MVP did not have higher anxiety scores compared to those without the syndrome. However, MVP patients with higher anxiety scores may benefit from a psychiatric assessment since higher scores correlate with symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_126_23","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T02:00:44Z","timestamp":1712109644000},"page":"331-336","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Are children with mitral valve prolapse more anxious?"],"prefix":"10.4103","volume":"16","author":[{"given":"Meryem","family":"Beyazal","sequence":"first","affiliation":[{"name":"Department of Paediatric Cardiology, Dr. Sami Ulus Gynaecology Obstetrics and Child Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku Arman","family":"Orun","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Dr. Sami Ulus Gynaecology Obstetrics and Child Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker Ufuk","family":"Sayici","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Dr. Sami Ulus Gynaecology Obstetrics and Child Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"R1-20240901","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199907013410101","article-title":"Prevalence and clinical outcome of mitral-valve prolapse","volume":"341","author":"Freed","year":"1999","journal-title":"N Engl J Med"},{"key":"R2-20240901","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/14779072.2019.1553619","article-title":"Mitral valve prolapse","volume":"17","author":"Althunayyan","year":"2019","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"R3-20240901","first-page":"467","article-title":"Posture and gender differentially affect heart rate variability of symptomatic mitral valve prolapse and normal adults","volume":"32","author":"Chang","year":"2016","journal-title":"Acta Cardiol Sin"},{"key":"R4-20240901","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cmpb.2016.04.018","article-title":"Association between anxiety state and mitral valve disorders:A Taiwanese population-wide observational study","volume":"132","author":"Dubey","year":"2016","journal-title":"Comput Methods Programs Biomed"},{"key":"R5-20240901","first-page":"226","article-title":"Assessment of autonomic dysfunction and anxiety levels in patients with mitral valve prolapse","volume":"37","author":"Orhan","year":"2009","journal-title":"Turk Kardiyol Dern Ars"},{"key":"R6-20240901","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.19082\/3483","article-title":"Effect of fluoxetine administration on clinical and echocardiographic findings in patients with mitral valve prolapse and generalized anxiety disorder:Randomized clinical trial","volume":"9","author":"Esfehani","year":"2017","journal-title":"Electron Physician"},{"key":"R7-20240901","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.amjmed.2016.05.004","article-title":"Mitral valve prolapse, psychoemotional status, and quality of life:Prospective investigation in the current era","volume":"129","author":"Bayer-Topilsky","year":"2016","journal-title":"Am J Med"},{"key":"R8-20240901","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1192\/bjp.bp.111.091934","article-title":"Mitral valve prolapse and anxiety disorders","volume":"199","author":"Filho","year":"2011","journal-title":"Br J Psychiatry"},{"key":"R9-20240901","first-page":"89","article-title":"Anxiety and mood disorder in young males with mitral valve prolapse","volume":"1","author":"Lung","year":"2008","journal-title":"J Multidiscip Healthc"},{"key":"R10-20240901","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1542\/peds.85.3.311","article-title":"Mitral valve prolapse:Associations with symptoms and anxiety","volume":"85","author":"Arfken","year":"1990","journal-title":"Pediatrics"},{"key":"R11-20240901","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.amjmed.2013.05.013","article-title":"Psycho-emotional manifestations of valvular heart diseases:Prospective assessment in mitral regurgitation","volume":"126","author":"Bayer-Topilsky","year":"2013","journal-title":"Am J Med"},{"key":"R12-20240901","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00004583-199910000-00011","article-title":"Psychometric properties of the screen for child anxiety related emotional disorders (SCARED):A replication study","volume":"38","author":"Birmaher","year":"1999","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"R13-20240901","article-title":"Unpublished Thesis","author":"\u00c7akmak\u00e7\u0131","year":"2004","journal-title":"Reliability and Validity of the Screen for Child Anxiety-Related Emotional Disorders (SCARED) in Turkish children"},{"key":"R14-20240901","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1037\/ort0000310","article-title":"Culturally adapted transdiagnostic CBT for SSRI resistant Turkish adolescents:A pilot study","volume":"89","author":"Acarturk","year":"2019","journal-title":"Am J Orthopsychiatry"},{"issue":"2","key":"R15-20240901","article-title":"The effectiveness of cognitive behavioral therapy, medication, or combined treatment for child hood anxiety disorders","volume":"27","author":"Sevi Tok","year":"2016","journal-title":"Turk Psikiyatri Derg"},{"key":"R16-20240901","doi-asserted-by":"crossref","first-page":"354","DOI":"10.5152\/npa.2017.17027","article-title":"Validity and reliability of the Turkish version of DSM-5 social anxiety disorder severity scale- child form","volume":"54","author":"Yalin Sapmaz","year":"2017","journal-title":"Noro Psikiyatr Ars"},{"key":"R17-20240901","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/ppul.24492","article-title":"Major depression and psychiatric comorbidity in Turkish children and adolescents with cystic fibrosis","volume":"54","author":"Gundogdu","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"R18-20240901","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/21622965.2016.1150184","article-title":"Assessment of neurocognitive functions in children and adolescents with obesity","volume":"6","author":"Bozkurt","year":"2017","journal-title":"Appl Neuropsychol Child"},{"key":"R19-20240901","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5455\/medarh.2018.72.9-12","article-title":"Assesment of rhythm disorders in classical and nonclassical mitral valve prolapse","volume":"72","author":"Hodzic","year":"2018","journal-title":"Med Arch"},{"key":"R20-20240901","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/01.CIR.75.1.175","article-title":"Color Doppler assessment of mitral regurgitation with orthogonal planes","volume":"75","author":"Helmcke","year":"1987","journal-title":"Circulation"},{"key":"R21-20240901","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0002-9343(82)90758-6","article-title":"Increased plasma catecholamine levels in patients with symptomatic mitral valve prolapse","volume":"73","author":"Pasternac","year":"1982","journal-title":"Am J Med"},{"key":"R22-20240901","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9343(87)90055-6","article-title":"Mitral valve prolapse with symptoms of beta-adrenergic hypersensitivity. Beta 2-adrenergic receptor supercoupling with desensitization on isoproterenol exposure","volume":"82","author":"Davies","year":"1987","journal-title":"Am J Med"},{"key":"R23-20240901","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/cvr\/cvx092","article-title":"Serotonin and catecholamines in the development and progression of heart valve diseases","volume":"113","author":"Goldberg","year":"2017","journal-title":"Cardiovasc Res"},{"key":"R24-20240901","doi-asserted-by":"crossref","first-page":"S317","DOI":"10.33549\/physiolres.934830","article-title":"Complex sympathetic regulation in adolescent mitral valve prolapse","volume":"70","author":"Bona Olexova","year":"2021","journal-title":"Physiol Res"},{"key":"R25-20240901","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00004583-199009000-00017","article-title":"Diagnosis of panic disorder in prepubertal children","volume":"29","author":"Vitiello","year":"1990","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"R26-20240901","first-page":"45","article-title":"Mitral valve prolapse and psychiatric complications:A case report","volume":"16","author":"Stavrakaki","year":"1991","journal-title":"J Psychiatry Neurosci"},{"key":"R27-20240901","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0022-3956(99)00005-9","article-title":"The prevalence of mitral valve prolapse in children with anxiety disorders","volume":"33","author":"Toren","year":"1999","journal-title":"J Psychiatr Res"},{"key":"R28-20240901","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.psychres.2013.09.027","article-title":"Gender differences in depression and anxiety:The role of age","volume":"210","author":"Faravelli","year":"2013","journal-title":"Psychiatry Res"}],"container-title":["Annals of Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_126_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:28:45Z","timestamp":1787768925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_126_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/apc.apc_126_23","relation":{},"ISSN":["0974-2069","0974-5149"],"issn-type":[{"value":"0974-2069","type":"print"},{"value":"0974-5149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-08-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}