{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:13:10Z","timestamp":1788966790078,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiac magnetic resonance imaging (MRI) T2* is the gold standard investigation for predicting cardiac iron overload. Being costly and resource-limited, other investigations that are cost-effective and easily available are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We studied various electrocardiographic and echocardiographic parameters of transfusion-dependent thalassemia patients between 2022 and 2024 in our tertiary pediatric cardiac center in southern India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among our 50 patients of the age group 8 years\u201330 years (mean age group: 19.9 years \u00b1 5.57), 62% of patients were males. Ninety-eight percent of our patients were asymptomatic, though 32% had MRI evidence of severe iron overload. Twenty-two percent of them had ferritin of more than 5000 \u00b5g\/dL. There was a significant difference in\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      wave dispersion, mitral valve E\/A, and E\/e\u2019 seen among patients with normal and abnormal cardiac MRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Regular follow-up with tracking of the electrocardiographic and echocardiographic parameters can be used as an effective screening to guide timing for cardiac MRI and titrate chelation therapy. Early identification of iron overload, prompt initiation of chelation therapy, and ensuring adequate compliance with medical treatment, along with titration of chelation based on serial assessments, play a major role in improving the quality of life and lifespan for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_133_25","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:19:14Z","timestamp":1788949154000},"page":"490-496","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of various electrocardiographic and echocardiographic parameters in beta thalassemia patients with iron overload"],"prefix":"10.4103","volume":"19","author":[{"given":"Haritha","family":"Girija","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnasamy Sivaprakasam","family":"Muthukumaran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ramkishore","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaguru","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mahitha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Apollo Children\u2019s Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"R1-20260909","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1749-6632.1998.tb10479.x","article-title":"Survival and disease complications in thalassemia major","volume":"850","author":"Borgna-Pignatti","year":"1998","journal-title":"Ann N Y Acad 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