{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:50Z","timestamp":1787840810119,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A 35-year-old pregnant woman was referred to our hospital because of fetal bradycardia. Fetal echocardiography revealed a normal fetal heart except for slightly prominent trabeculae in the left ventricle, normal cardiac function, and fetal sinus bradycardia with a heart rate of 100 bpm. Electrocardiography (ECG) after birth revealed sinus bradycardia with a heart rate of 70\u201380 bpm. Transthoracic echocardiography revealed left ventricular noncompaction localized in the apex with normal cardiac function. A 24-h Holter ECG showed a heart rate range of 62\u2013169 bpm without a pause of more than 2 s. A genome analysis performed during the neonatal period revealed a heterozygous inflame variant p.(Ser672_Asp676del)[chr15:g. 73324203_733242] in HCN4 gene. Fetuses with a heart rate less than the 3\n                    <jats:sup>rd<\/jats:sup>\n                    percentile of the gestational age should be followed and screened for congenital heart disease and cardiomyopathy. In addition, inherited arrhythmia syndrome should be considered.\n                  <\/jats:p>","DOI":"10.4103\/apc.apc_138_24","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:00:18Z","timestamp":1731664818000},"page":"295-297","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Fetal bradycardia associated with left ventricle noncompaction diagnosed as HCN4 mutations"],"prefix":"10.4103","volume":"17","author":[{"given":"Kosuke","family":"Yonehara","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Nagano Children\u2019s Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"R1-20250107","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/hc3501.094231","article-title":"Identification of fetal atrial flutter by Doppler tissue imaging","volume":"104","author":"Cotton","year":"2001","journal-title":"Circulation"},{"key":"R2-20250107","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.hrcr.2020.03.003","article-title":"The missense variant p.(Gly482Arg) in HCN4 is responsible for fetal tachy-bradycardia syndrome","volume":"6","author":"Wacker-Gussmann","year":"2020","journal-title":"HeartRhythm Case Rep"},{"key":"R3-20250107","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.3390\/jcm12134464","article-title":"Fetal heart rate <3rd percentile for gestational age can be a marker of inherited arrhythmia syndromes","volume":"12","author":"Chaudhry-Waterman","year":"2023","journal-title":"J Clin Med"},{"key":"R4-20250107","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/genes13030477","article-title":"Clinical presentation of left ventricular noncompaction cardiomyopathy and bradycardia in three families carrying HCN4 pathogenic variants","volume":"13","author":"Paszkowska","year":"2022","journal-title":"Genes (Basel)"},{"key":"R5-20250107","first-page":"287","article-title":"Noncompaction cardiomyopathy, sick sinus disease, and aortic dilatation:Too much for a single diagnosis?JACC Case Rep","volume":"4","author":"Brunet-Garcia","year":"2022"},{"key":"R6-20250107","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.hrthm.2017.01.020","article-title":"Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction","volume":"14","author":"Ishikawa","year":"2017","journal-title":"Heart Rhythm"},{"key":"R7-20250107","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00392-019-01465-3","article-title":"Clinical and genetic insights into non-compaction:A meta-analysis and systematic review on 7598 individuals","volume":"108","author":"Kayvanpour","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"R8-20250107","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1253\/circj.CJ-20-1148","article-title":"Clinical Characteristics and prognosis of fetal left ventricular noncompaction in Japan","volume":"86","author":"Ozawa","year":"2021","journal-title":"Circ J"}],"container-title":["Annals of Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_138_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:20Z","timestamp":1787837360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_138_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/apc.apc_138_24","relation":{},"ISSN":["0974-2069","0974-5149"],"issn-type":[{"value":"0974-2069","type":"print"},{"value":"0974-5149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-07-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}