{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:21Z","timestamp":1787772441841,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Noonan syndrome (NS) is a pleomorphic genetic disorder. Up to 50-80% of individuals have associated congenital heart disease. The scope of cardiac disease in NS is quite variable depending on the gene mutation. The most common forms of cardiac defects include pulmonary stenosis, hypertrophic cardiomyopathy (HCM), atrial septal defect and left-sided lesions. Amongst the rare vascular abnormalities few case reports have been mentioned about coronary artery lesions apart from sinus of Valsalva aneurysm, aortic dissection, intracranial aneurysm. This is a case report a rare case of asymptomatic coronary artery aneurysm in a young male with NS. There is lack of unified protocol for the screening, diagnosis, treatment, and follow-up of coronary artery disease in patients with NS. We conclude, echocardiography is sufficient in most cases in children. But a CT scan is appropriate in adults or when other lesions are suspected.<\/jats:p>","DOI":"10.4103\/apc.apc_145_23","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:05:09Z","timestamp":1716469509000},"page":"70-73","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Coronary arteriopathy in a patient with Noonan phenotype: Case report"],"prefix":"10.4103","volume":"17","author":[{"given":"Simran","family":"Jain","sequence":"first","affiliation":[{"name":"Consultant, Department of Pediatric Cardiology, Sri Sathya Sai Sanjeevani Hospital, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Ravindra","sequence":"additional","affiliation":[{"name":"Consultant, Department of Pediatric Cardiology, Sri Sathya Sai Sanjeevani Hospital, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh Chintaman","family":"Sathe","sequence":"additional","affiliation":[{"name":"Head, Department of Pediatric Cardiology, Sri Sathya Sai Sanjeevani Hospital, Muddenahalli, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal M.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Sri Sathya Sai Sanjeevani Centre for Child Heart Care and Training in Pediatric Cardiac Skills, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Banpurkar","sequence":"additional","affiliation":[{"name":"Consultant, Department of Pediatric Cardiology, Sri Sathya Sai Sanjeevani Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"R1-20240901","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ajmg.c.31765","article-title":"Congenital heart defects in Noonan syndrome: Diagnosis, management, and treatment","volume":"184","author":"Linglart","year":"2020","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"R2-20240901","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.genom.6.080604.162305","article-title":"Noonan syndrome and related disorders: Genetics and pathogenesis","volume":"6","author":"Tartaglia","year":"2005","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"R3-20240901","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ajmg.a.37505","article-title":"Coronary artery ectasia in Noonan syndrome: Report of an individual with SOS1 mutation and literature review","volume":"170","author":"Calcagni","year":"2016","journal-title":"Am J Med Genet A"},{"key":"R4-20240901","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00246-002-0155-y","article-title":"Proximal left coronary artery occlusion in a 15-year-old boy with Noonan syndrome and hypertrophic cardiomyopathy","volume":"24","author":"Delhaas","year":"2003","journal-title":"Pediatr Cardiol"},{"key":"R5-20240901","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1016\/j.ijcard.2014.03.135","article-title":"Bilateral giant coronary aneurysms in a 40-year-old male with Noonan syndrome caused by a KRAS germline mutation","volume":"173","author":"Fujimoto","year":"2014","journal-title":"Int J Cardiol"},{"key":"R6-20240901","first-page":"318","article-title":"Ectatic coronary arteries in Noonan syndrome","volume":"38","author":"Gulati","year":"2011","journal-title":"Tex Heart Inst J"},{"key":"R7-20240901","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.hlc.2013.03.079","article-title":"Coronary artery ectasia in an adult Noonan syndrome detected on coronary CT angiography","volume":"22","author":"Hakim","year":"2013","journal-title":"Heart Lung Circ"},{"key":"R8-20240901","first-page":"S80","article-title":"A case report of Noonan's syndrome with pulmonary valvar stenosis and coronary aneurysms","volume":"10","author":"Loukas","year":"2004","journal-title":"Med Sci Monit"},{"key":"R9-20240901","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00247-015-3472-z","article-title":"Development of bilateral coronary artery aneurysms in a child with Noonan syndrome","volume":"46","author":"Mauro","year":"2016","journal-title":"Pediatr Radiol"},{"key":"R10-20240901","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1253\/jcj.64.481","article-title":"Bilateral coronary artery dilatation in a child with Noonan syndrome","volume":"64","author":"Nomura","year":"2000","journal-title":"Jpn Circ J"},{"key":"R11-20240901","doi-asserted-by":"crossref","first-page":"e009429","DOI":"10.1161\/CIRCIMAGING.119.009429","article-title":"Case of Noonan syndrome with an expanding coronary arterial aneurysm","volume":"12","author":"Ogihara","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"R12-20240901","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0971-9784.129859","article-title":"Ectatic coronary arteries in a patient with Noonan syndrome on transoesophageal echocardiography","volume":"17","author":"Ramaiah","year":"2014","journal-title":"Ann Card Anaesth"},{"key":"R13-20240901","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng772","article-title":"Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome","volume":"29","author":"Tartaglia","year":"2001","journal-title":"Nat Genet"},{"key":"R14-20240901","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1476-7120-1-16","article-title":"Imaging of all three coronary arteries by transthoracic echocardiography. 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