{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:15Z","timestamp":1786653555643,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Research on pediatric restrictive cardiomyopathy\u00a0(RCM), especially from the developing world, is limited. The study aimed to describe the clinical features and outcomes of childhood RCM and the predictors of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included all children with RCM who were\u00a0&lt;\u00a018\u00a0years old. Exclusion criteria were prior exposure to chemotherapy or radiotherapy, reduced left ventricular\u00a0(LV) ejection fraction, congenital heart defects not part of any malformation syndromes, and RCM with thickened LV wall or septal thickness signifying any overlap with hypertrophic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the 30-year study period\u00a0(1990\u20132020), 233\u00a0cases of pediatric cardiomyopathy were identified, out of which 33\u00a0cases had RCM\u00a0(14%). No RCM patient presented in the neonatal period, and 12% had presented in infancy. A\u00a0syndromic, metabolic, or genetic disease was identified in 9% of cases. Endomyocardial fibrosis was diagnosed in four\u00a0(12%) children. Two patients were in atrial fibrillation, one in atrial flutter, two were in junctional rhythm, and 21.8% had first-degree atrioventricular block. Twelve patients had cardiac magnetic resonance imaging done. Subendocardial late gadolinium enhancement was present in five. Out of the 33\u00a0patients, the outcome is known in 15, out of whom eight died and seven were alive. Four died of sudden cardiac death, and four from heart failure. The 5-year survival rate of RCM was calculated to be 67%, and the 10-year survival rate was 48%. The relationship between death and a history of syncope was close to statistical significance\u00a0(\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>RCM constituted a higher proportion of pediatric cardiomyopathies in our study than reported in most published literature. Despite relatively early clinical presentation, survival outcomes of pediatric RCM tend to be worse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_169_24","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T08:00:13Z","timestamp":1752480013000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical profile of restrictive cardiomyopathy in children at a South Indian tertiary care cardiac center: A retrospective three decade experience"],"prefix":"10.4103","volume":"18","author":[{"given":"Gousia Mukhtar","family":"Kawoos","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, SCTIMST, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, SCTIMST, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavassery Mahadevan","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, SCTIMST, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijulal","family":"Sasidharan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, SCTIMST, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishnan K. 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