{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:54Z","timestamp":1787775714521,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Stent thrombosis, a potential complication of ductal stenting, is associated with high mortality. This is a catastrophic complication, which can occur acutely (within 24 h), subacutely (within 30 days), or late (\u226530 days) after stent implantation, with rates between 0.8% and 25%. Oral antiplatelet drugs like aspirin have erratic and inconsistent absorption and antiplatelet effects in critically ill neonates. Intravenous (IV) glycoprotein IIb\/IIIa inhibitors (GPIs) are antiplatelet agents with rapid effect (84% inhibition of platelet aggregation 15 min after bolus) that may help prevent this catastrophic complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study was conducted among 127 neonates with a median age of 1 month, of which 48% were male, undergoing ductal stenting procedures between January 2022 and March 2024 at our center who received an IV eptifibatide bolus of 180 \u00b5g\/kg immediately postprocedure. Dosing simulations were generated based on extrapolation from the adult model. The primary outcome measures were stent thrombosis and bleeding events, whereas the secondary outcomes included platelet count.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Stent thrombosis occurred in one of the patients after prophylactic treatment with eptifibatide. Five patients experienced bleeding complications. Eight patients had thrombocytopenia, as thrombosis is prevented via the adenosine diphosphate pathway. The treatment did not affect serum creatinine and liver function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IV GPIs are safe in neonates after a ductal stenting procedure as an adjunct to oral antiplatelet therapy. Dosing considerations should include age and renal function. Randomized trials are warranted to establish efficacy and compare with current anticoagulation practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_175_24","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T14:00:54Z","timestamp":1745503254000},"page":"415-419","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Eptifibatide bolus dose postductal stenting intervention: A single-center experience"],"prefix":"10.4103","volume":"17","author":[{"given":"Rishika","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Narayana Superspeciality Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabha","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Narayana Superspeciality Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aritra","family":"Mukherji","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Narayana Superspeciality Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiban","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Narayana Superspeciality Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayita Nandy","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Narayana Superspeciality Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpanjali","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Narayana Superspeciality Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"R1-20250424","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/CIRCULATIONAHA.118.035224","article-title":"Response by Bentham to letter regarding article, duct stenting versus modified Blalock-Taussig shunt in neonates with duct-dependent pulmonary blood flow:Associations with clinical outcomes in a multicenter national study","volume":"138","author":"Bentham","year":"2018","journal-title":"Circulation"},{"key":"R2-20250424","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ccd.25949","article-title":"Ten-years, single-center experience with arterial duct stenting in duct-dependent pulmonary circulation:Early results, learning-curve changes, and mid-term outcome","volume":"86","author":"Santoro","year":"2015","journal-title":"Catheter Cardiovasc 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Res"},{"key":"R13-20250424","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/apc.apc_120_23","article-title":"The paucity of high-level evidence for therapy in pediatric cardiology","volume":"16","author":"Littman","year":"2023","journal-title":"Ann Pediatr Cardiol"},{"key":"R14-20250424","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/apc.apc_196_24","article-title":"Pediatric cardiac interventions:Innovations from India","volume":"17","author":"Mantoo","year":"2024","journal-title":"Ann Pediatr Cardiol"},{"key":"R15-20250424","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/apc.apc_71_24","article-title":"The outcome of surgery for congenital heart disease in India:A systematic review and metanalysis","volume":"17","author":"Kadiyani","year":"2024","journal-title":"Ann Pediatr Cardiol"}],"container-title":["Annals of Pediatric 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