{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:49Z","timestamp":1786649569413,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Children with one functional ventricle might receive the Fontan procedure as palliative management to prolong their lives. However, the heart remains functionally univentricular, which may result in disrupted absorption of nutrients, including Vitamin D. Individuals with Fontan circulation have limited physical activity and sun exposure, which might further contribute to Vitamin D deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to estimate the prevalence of Vitamin D deficiency among individuals with Fontan circulation and analyze probable contributing factors to it through meta-regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A predetermined search strategy was applied on PubMed, Scopus, Scilit, Web of Science, Europe PMC, and Google Scholar to identify relevant literature as of July 2024. In general, studies reporting the prevalence or incidence of Vitamin D deficiency (&lt;20 ng\/mL) among Fontan patients were eligible for inclusion. Only cohort and cross-sectional studies were included. The pooled estimates were carried out using a restricted maximum-likelihood model and Freeman\u2013Tukey double-arcsine transformation (FTT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Six studies were included, comprising 255 individuals with the Fontan circulation. The prevalence of Vitamin D deficiency was 51% (95% confidence interval: 35%\u2013 67%) with noticeable heterogeneity (\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 84.38%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Het &lt;0.001). Extracardiac conduit\/lateral tunnel (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) was the main contributor to the heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitamin D deficiency is highly prevalent among individuals with Fontan palliation, highlighting the need for active monitoring and investigation into the benefits of Vitamin D supplementation.<\/jats:p>\n                    <jats:p>PROSPERO registration: CRD42024574724.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_184_24","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T06:00:11Z","timestamp":1735020011000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of Vitamin D deficiency among individuals with Fontan palliation: A systematic review and meta-analysis"],"prefix":"10.4103","volume":"17","author":[{"given":"Firyal","family":"Khansa","sequence":"first","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chairul","family":"Ichwan","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Haneef","family":"Ghifari","sequence":"additional","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Brilliant","family":"Daffa","sequence":"additional","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah Rizky","family":"Nadia","sequence":"additional","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putri Oktaviani","family":"Zulfa","sequence":"additional","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derren David Christian Homenta","family":"Rampengan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Sam Ratulangi, Manado, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Yufika","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia"},{"name":"Physical Medicine and Rehabilitation Residency Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naufal","family":"Gusti","sequence":"additional","affiliation":[{"name":"Postgraduate School of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Iqhrammullah","sequence":"additional","affiliation":[{"name":"Postgraduate School of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"R1-20241224","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1017\/S104795111800135X","article-title":"Hypoplastic left heart syndrome: From fetus to fontan","volume":"28","author":"Roeleveld","year":"2018","journal-title":"Cardiol 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Cardiol"},{"key":"R5-20241224","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s12325-021-02002-3","article-title":"The epidemiology of persons living with Fontan in 2020 and projections for 2030: Development of an epidemiology model providing multinational estimates","volume":"39","author":"Plappert","year":"2022","journal-title":"Adv Ther"},{"key":"R6-20241224","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1093\/eurheartj\/ehab826","article-title":"Predictors of long-term mortality among perioperative survivors of Fontan operation","volume":"43","author":"Inai","year":"2022","journal-title":"Eur Heart J"},{"key":"R7-20241224","doi-asserted-by":"crossref","first-page":"1100514","DOI":"10.3389\/fped.2023.1100514","article-title":"Fontan-associated liver disease: Diagnosis, surveillance, and management","volume":"11","author":"de Lange","year":"2023","journal-title":"Front 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Disease"},{"key":"R11-20241224","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.jiph.2023.08.005","article-title":"Myocarditis manifestations in dengue cases: A systematic review and meta-analysis","volume":"16","author":"Sandeep","year":"2023","journal-title":"J Infect Public Health"},{"key":"R13-20241224","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1136\/heartjnl-2014-305723","article-title":"Lean mass deficits, Vitamin D status and exercise capacity in children and young adults after Fontan palliation","volume":"100","author":"Avitabile","year":"2014","journal-title":"Heart"},{"key":"R14-20241224","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1017\/S1047951121003115","article-title":"Vitamin D, liver-related biomarkers, and distribution of fat and lean mass in young patients with Fontan circulation","volume":"32","author":"Hansson","year":"2022","journal-title":"Cardiol 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prevalence of Vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants","volume":"10","author":"Cui","year":"2023","journal-title":"Front Nutr"},{"key":"R19-20241224","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1542\/peds.2011-3059","article-title":"The association of Vitamin D status with pediatric critical illness","volume":"130","author":"McNally","year":"2012","journal-title":"Pediatrics"},{"key":"R20-20241224","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s00134-012-2718-6","article-title":"Vitamin D status in critically ill children","volume":"38","author":"Rippel","year":"2012","journal-title":"Intensive Care Med"},{"key":"R21-20241224","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000511058","article-title":"A randomized, double-blind, placebo-controlled, clinical trial of high-dose, short-term Vitamin D administration in the prevention of acute kidney injury after cardiac surgery","volume":"11","author":"Eslami","year":"2021","journal-title":"Cardiorenal Med"},{"key":"R22-20241224","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11914-021-00673-z","article-title":"Do interactions of Vitamin D(3) and BMP signaling hold implications in the pathogenesis of fibrodysplasia ossificans progressiva?","volume":"19","author":"Pierce","year":"2021","journal-title":"Curr Osteoporos Rep"},{"key":"R23-20241224","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fendo.2019.00470","article-title":"The Vitamin D binding protein and inflammatory injury: A mediator or sentinel of tissue damage?","volume":"10","author":"Kew","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R24-20241224","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jtcvs.2019.11.048","article-title":"Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit","volume":"159","author":"Weixler","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R25-20241224","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.52225\/narrax.v1i3.104","article-title":"Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials","volume":"1","author":"Putra","year":"2023","journal-title":"Narra X"}],"container-title":["Annals of Pediatric 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History"}},{"value":"2024-11-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}