{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:03Z","timestamp":1786649643719,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Percutaneous device closure of patent ductus arteriosus (PDA) in infants and children is a frequently performed procedure. However, transcatheter closure is rare in adults, especially in developed countries, as most ducts are typically closed in childhood. PDA in adults poses unique challenges due to age-related comorbidities and some morphological changes in PDA that occur with advanced age. This study analyzes the safety and procedural success of adult PDA transcatheter closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective single-center study analyzed 184 adult PDA device closures between July 2015 and July 2024. The study examined patient demographics, clinical aspects, procedural details, and immediate hospital outcomes. Outcome parameters focused on procedural success, complications, residual shunt, and improvement in symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of 184 patients, 183 adults with a mean age of 27 \u00b1 13 years and a mean weight of 52 \u00b1 16.5 kg underwent PDA device occlusion. Most patients were referred for evaluation of a murmur (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 116, 63.3%). The most common comorbidity was type 2 diabetes mellitus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20, 10.9%). The mean PDA diameter at its narrowest end was 6.17 \u00b1 4.56 mm (1.2\u201317 mm). In total, 6.55% of patients exhibited duct calcification, and 2.73% presented with a PDA aneurysm. Severe pulmonary hypertension was present in 24 patients. Transcatheter intervention achieved a 100% success rate at 24 h postprocedure, with no residual flows at the 6-month follow-up. There was no mortality, device embolization, or aortic\/pulmonary artery stenosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Percutaneous device closure is a safe and successful treatment option for PDA in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_214_24","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T18:00:36Z","timestamp":1767722436000},"page":"455-459","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Procedural outcome and safety of percutaneous patent ductus arteriosus occlusion in adults"],"prefix":"10.4103","volume":"18","author":[{"given":"Abdul Malik","family":"Sheikh","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Kanwal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Sattar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauqeer","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Najam","family":"Hyder","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyaba","family":"Saher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.clp.2021.11.009","article-title":"Percutaneous closure of patent ductus arteriosus","volume":"49","author":"Barcroft","year":"2022","journal-title":"Clin Perinatol"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"e025784","DOI":"10.1161\/JAHA.122.025784","article-title":"Patent ductus arteriosus: A contemporary perspective for the pediatric and adult cardiac care provider","volume":"11","author":"Backes","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"R3-20260420","first-page":"89","article-title":"Role of 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hypertension","volume":"12","author":"Zhou","year":"2023","journal-title":"J Clin Med"},{"key":"R10-20260420","first-page":"259","article-title":"Closure of persistent ductus arteriosus without thoracotomy","volume":"12","author":"Porstmann","year":"1967","journal-title":"Ger Med Mon"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0002-9149(89)90064-7","article-title":"Angiographic classification of the isolated, persistently patent ductus arteriosus and implications for percutaneous catheter occlusion","volume":"63","author":"Krichenko","year":"1989","journal-title":"Am J Cardiol"},{"key":"R12-20260420","first-page":"837","article-title":"Clinical outcomes after percutaneous patent ductus arteriosus closure in adults","volume":"36","author":"Wilson","year":"2020","journal-title":"Can J Cardiol"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/0974-2069.189125","article-title":"Pattern of congenital heart disease in a developing country tertiary care center: Factors associated with delayed diagnosis","volume":"9","author":"Rashid","year":"2016","journal-title":"Ann Pediatr Cardiol"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12872-020-01781-x","article-title":"Global prevalence of congenital heart disease in school-age children: A meta-analysis and systematic review","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Cardiovasc Disord"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3346\/jkms.2007.22.3.484","article-title":"Complications after transcatheter closure of patent ductus arteriosus","volume":"22","author":"Jang","year":"2007","journal-title":"J Korean Med Sci"},{"key":"R16-20260420","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fped.2019.00409","article-title":"Echocardiographic prediction of left ventricular dysfunction after transcatheter patent ductus arteriosus closure in children","volume":"7","author":"Hou","year":"2019","journal-title":"Front Pediatr"},{"key":"R18-20260420","first-page":"100316","article-title":"Off-label use of Lifetech KONAR-MF\u2122 ventricular septal defect occluder for large patent ductus arteriosus closure in <6 kg infants","volume":"7","author":"Grunenwald Gronier","year":"2022","journal-title":"Int J Cardiol Congenit Heart Dis"}],"container-title":["Annals of Pediatric 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