{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:15Z","timestamp":1786653555675,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tetralogy of Fallot\u00a0(TOF), the most prevalent cyanotic congenital heart anomaly, impacts around 3.9 in 10,000 live births. Repair aims to address intracardiac shunting and right ventricular outflow tract obstruction. Despite successful historical surgeries, the optimal timing for repair remains debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of the study was to provide an updated comparison of the TOF repair timing\u00a0(neonatal vs. postneonatal periods) based on post-\u00a0and perioperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A literature search was conducted across PubMed, Scopus, EBSCO, Science Direct, and Epistemonikos. Quality assessment was performed using the Risk of Bias in Non-Randomized Studies of Interventions, whereas the outcomes were analyzed using RevMan 5.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nineteen studies comprising 28,968\u00a0patients were included in the study. All studies were classified as high-quality. The neonatal repair exhibited longer intensive care unit\u00a0(ICU) stays\u00a0(standard mean differences\u00a0[SMD] 1.58; 95% confidence interval\u00a0[CI] 1.04\u20132.12;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001) and hospital stays\u00a0(SMD 5.18; 95% CI 3.54\u20136.82;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001). Moreover, the analysis showed an overall result favoring the postneonatal repair, including mortality\u00a0(odds ratio\u00a0[OR] 1.68; 95% CI 1.47\u20131.92;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001), delayed chest closure\u00a0(OR 2.52; 95% CI 2.06\u20133.09;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001), and pacemaker implantation\u00a0(OR 3.68; 95% CI 2.89\u20134.70;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Complete repair during the post-neonatal period yielded better postoperative outcomes, shorter hospital stays, ICU stays, and ventilation time.<\/jats:p>\n                    <jats:p>PROSPERO registration: CRD42024503630.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_228_24","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T08:00:16Z","timestamp":1752480016000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Determining the optimal timing for Tetralogy of Fallot management: A meta-analysis of neonatal vs postneonatal repairs"],"prefix":"10.4103","volume":"18","author":[{"given":"Starry Homenta","family":"Rampengan","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Medical Faculty of Sam Ratulangi University\/Prof. Dr. R.D. 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Ngoerah General Hospital, Denpasar, Bali, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Valentina","family":"Ariyanto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Iqhrammullah","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth prevalence of congenital heart disease worldwide: A systematic review and meta-analysis","volume":"58","author":"van der Linde","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S2352-4642(19)30402-X","article-title":"Global, regional, and national burden of congenital heart disease, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"4","author":"Zimmerman","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"key":"R4-20260421","doi-asserted-by":"crossref","first-page":"e2314504","DOI":"10.1001\/jamanetworkopen.2023.14504","article-title":"Survival trends in children with tetralogy of fallot in Sweden from 1970 to 2017","volume":"6","author":"Persson","year":"2023","journal-title":"JAMA Netw Open"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cjcpc.2023.10.006","article-title":"Considerations in timing of surgical repair in tetralogy of fallot","volume":"2","author":"Al Mosa","year":"2023","journal-title":"CJC Pediatr Congenit Heart Dis"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12871-023-02290-y","article-title":"Effect of hemoglobin and oxygen saturation on adverse outcomes in children with tetralogy of fallot: A retrospective observational study","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Anesthesiol"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jtcvs.2019.10.172","article-title":"Surgical treatment of tetralogy of fallot in symptomatic neonates and young infants","volume":"159","author":"Jeon","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R8-20260421","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18103\/mra.v11i11.4231","article-title":"Tetralogy of fallot: Early diagnosis and treatment and its impact on survival rates","volume":"11","author":"Lemos","year":"2023","journal-title":"Med Res Arch"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jtcvs.2022.07.025","article-title":"The American Association for Thoracic Surgery (AATS) 2022 expert consensus document: Management of infants and neonates with tetralogy of fallot","volume":"165","author":"Miller","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R10-20260421","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.athoracsur.2019.10.013","article-title":"Staged versus complete repair in the symptomatic neonate with tetralogy of fallot","volume":"109","author":"Bailey","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"R11-20260421","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jtcvs.2021.01.100","article-title":"Comparison of management strategies for neonates with symptomatic tetralogy of fallot and weight<2.5 kg","volume":"163","author":"Qureshi","year":"2022","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R12-20260421","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"R13-20260421","first-page":"e94","article-title":"Acceptance, safety, and impact on quality of life of exergame for elderly patients with neurodegenerative diseases: A systematic review and meta-analysis","volume":"1","author":"Tsurayya","year":"2023","journal-title":"Narra X"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.52225\/narrax.v2i1.123","article-title":"Can smartphone-based diabetes control apps improve cardiovascular risk among patients with diabetes? 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