{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:19Z","timestamp":1786653559586,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n Background:<\/jats:title>\n Pulmonary arterial hypertension\u00a0(PAH) is a chronic, progressive disease affecting the pulmonary vasculature, with a high mortality rate. Patients with PAH due to congenital heart disease\u00a0(CHD)\u00a0(World Health Organization Group\u00a01) exhibit significantly reduced exercise tolerance compared to other PAH groups. Right ventricular\u00a0(RV) dysfunction is a commonly used independent prognostic parameter in PAH. This study aimed to investigate an echocardiographic-derived parameter of RV-pulmonary artery\u00a0(PA) coupling to exercise tolerance in PAH-CHD.<\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods:<\/jats:title>\n This cross-sectional study was performed on 51 consecutive patients with a confirmed diagnosis of PAH-CHD between February and March 2024. These patients underwent a 6-minute walk test (6MWT)\u00a0and echocardiographic evaluation, including the measurement of tricuspid annular plane systolic excursion\u00a0(TAPSE), pulmonary artery systolic pressure\u00a0(PASP), TAPSE\/PASP, and tricuspid regurgitation velocity\u00a0(TRV) as parameters of RV function. The data were analyzed using the IBM SPSS Statistics software\u00a0(version\u00a026.0).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Fourteen men and 37 women aged 36.0\u00a0\u00b1\u00a011.2\u00a0years participated in this study. The most common CHD was atrial septal defect\u00a0(88.2%) with left-to-right shunt (51.0%). The mean of 6MWT was 366.8\u00a0\u00b1\u00a060.6\u00a0m. There was a significant association between 6MWT and TAPSE (\n r<\/jats:italic>\n \u00a0=\u00a00.330,\n P<\/jats:italic>\n \u00a0<\u00a00.05), PASP (\n r<\/jats:italic>\n = \u22120.273,\n P<\/jats:italic>\n \u00a0<\u00a00.05), TAPSE\/PASP (\n r<\/jats:italic>\n \u00a0=\u00a00.392,\n P<\/jats:italic>\n \u00a0<\u00a00.05), and TRV (\n r<\/jats:italic>\n = \u22120.354,\n P<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The TAPSE\/PASP is a simple echocardiographic parameter that correlates with RV function and exercise tolerance in patients with PAH-CHD.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/apc.apc_230_24","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T08:00:12Z","timestamp":1752480012000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Echocardiographic correlation of right ventricular\u2013Pulmonary artery coupling to exercise tolerance in congenital heart disease-associated pulmonary hypertension"],"prefix":"10.4103","volume":"18","author":[{"given":"Anudya Kartika","family":"Ratri","sequence":"first","affiliation":[{"name":"Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"},{"name":"Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovin Nada","family":"Saputri","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Adrian","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisia Yuana","family":"Putri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meity","family":"Ardiana","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Prevention and Rehabilitation, Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budi Susetyo","family":"Pikir","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Gde Rurus","family":"Suryawan","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","article-title":"Definitions and diagnosis of pulmonary hypertension","volume":"62","author":"Hoeper","year":"2013","journal-title":"J Am Coll 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spinotrapezius muscle","volume":"106","author":"Schulze","year":"2021","journal-title":"Exp Physiol"}],"container-title":["Annals of Pediatric 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History"}},{"value":"2025-04-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}