{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:43Z","timestamp":1786649383636,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aortic coarctation\u00a0(CoA) accounts for 5%\u20138% of congenital heart defects, and patients\u2019 symptoms can range from neonatal shock to hypertension in adolescence or even adulthood. While surgical repair is the gold standard, catheter-based therapies are increasingly utilized. Despite advancements, complications, and recurrence rates necessitating re-intervention remain concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We analyzed the postoperative outcomes and long-term intervention rates for pediatric patients undergoing extended end-to-end CoA repair without cardiopulmonary bypass between October 2002 and January 2024 at the Leipzig Heart Center. Data were prospectively collected and retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 168\u00a0patients, the median age at surgery was 11\u00a0days\u00a0(interquartile range\u00a0[IQR] 6\u201326). There was no early mortality. Median intensive care unit stay was 4\u00a0days\u00a0(IQR 3-5), and hospital stay was 9\u00a0days\u00a0(IQR 7\u201312). Early re-intervention during the same hospital stay was required in 3% due to re-coarctation. Median follow-up was 33\u00a0months\u00a0(IQR 7\u00a0months-8\u00a0years). Long-term survival at 1, 5, 10, and 14\u00a0years was 100%, 98.9%, 98.9%, and 98.9%, respectively. Freedom from catheter-based intervention was 74.3%, 70.1%, 67.9%, and 64.8% at the same intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Extended end-to-end anastomosis for CoA repair in children yields excellent survival and acceptable long-term outcomes, though re-intervention remains a consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_249_24","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T08:00:10Z","timestamp":1752480010000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes after coarctation surgery in a pediatric population at Heart Center Leipzig \u2013 A two-decade experience"],"prefix":"10.4103","volume":"18","author":[{"given":"Katja","family":"Schumacher","sequence":"first","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"de la Cuesta","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Marin-Cuartas","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Ikbal","family":"Aydin","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Meier","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"D\u00e4hnert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Borger","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kostelka","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Vollroth","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.athoracsur.2024.04.012","article-title":"The Society of Thoracic Surgeons clinical practice guidelines on the management of neonates and infants with coarctation","volume":"118","author":"Stephens","year":"2024","journal-title":"Ann Thorac Surg"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.athoracsur.2017.03.084","article-title":"Aortic coarctation repair: How I teach it","volume":"104","author":"Mitchell","year":"2017","journal-title":"Ann Thorac 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approach","volume":"80","author":"Wright","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.athoracsur.2003.07.045","article-title":"Is extended arch aortoplasty the operation of choice for infant aortic coarctation? Results of 15 years\u2019 experience in 181 patients","volume":"77","author":"Wood","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"R10-20260421","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4103\/apc.APC_5_18","article-title":"Early outcomes of modification of end to side repair of coarctation of aorta with arch hypoplasia in neonates and infants","volume":"11","author":"Dharmapuram","year":"2018","journal-title":"Ann Pediatr Cardiol"},{"key":"R11-20260421","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/apc.apc_71_24","article-title":"The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis","volume":"17","author":"Kadiyani","year":"2024","journal-title":"Ann Pediatr Cardiol"},{"key":"R12-20260421","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/icvts\/ivz117","article-title":"Risk factors of mortality and recoarctation after coarctation repair in infancy","volume":"29","author":"Lehnert","year":"2019","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ejcts\/ezy252","article-title":"Procedural risk factors, incidence and timing of reintervention after treatment for native coarctation of the aorta in children: A population-based study\u2020","volume":"55","author":"Ylinen","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"1144755","DOI":"10.3389\/fcvm.2023.1144755","article-title":"Risk factors for recurrence after surgical repair of coarctation of the aorta in children: A single-center experience based on 51 children","volume":"10","author":"Zhao","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"R15-20260421","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/apc.apc_140_22","article-title":"Progressive changes in residual gradient after aortic coarctation repair and its role in the prediction of reintervention: A longitudinal data analysis","volume":"16","author":"Eldadah","year":"2023","journal-title":"Ann Pediatr Cardiol"}],"container-title":["Annals of Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_249_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:53:24Z","timestamp":1786647204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_249_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/apc.apc_249_24","relation":{},"ISSN":["0974-2069","0974-5149"],"issn-type":[{"value":"0974-2069","type":"print"},{"value":"0974-5149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}