{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:02Z","timestamp":1787840222668,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Congenital Heart Diseases occur in close to 90% of children with Trisomy 18. A ventricular septal defect along with abnormalities of more than one cardiac valve is considered to be an imaging hallmark of Trisomy 18. We present echocardiographic images of an infant with Trisomy 18 who had a large ventricular septal defect and abnormalities of all cardiac valves.<\/jats:p>","DOI":"10.4103\/apc.apc_271_20","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:06:01Z","timestamp":1648220761000},"page":"559-560","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Septal defect with polyvalvular involvement: A cardiac imaging hallmark of Trisomy 18"],"prefix":"10.4103","volume":"14","author":[{"given":"Usha Nandhini","family":"Sennaiyan","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, R.K. Hospital for Women and Children, Thanjavur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kiruthika","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Thanjavur Medical College, Thanjavur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani Ram","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, R.K. Hospital for Women and Children, Thanjavur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"R1-20250602","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ajmg.1320490203","article-title":"Survival in trisomy 18","volume":"49","author":"Root","year":"1994","journal-title":"Am J Med Genet"},{"key":"R2-20250602","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1750-1172-7-81","article-title":"The trisomy 18 syndrome","volume":"7","author":"Cereda","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"R3-20250602","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/0735-1097(89)90353-7","article-title":"Cardiac malformations in trisomy-18: A study of 41 postmortem cases","volume":"13","author":"Van Praagh","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"R4-20250602","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ajmg.1320140409","article-title":"Congenital heart anomalies in the trisomy 18 syndrome, with reference to congenital polyvalvular disease","volume":"14","author":"Matsuoka","year":"1983","journal-title":"Am J Med Genet"}],"container-title":["Annals of Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_271_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:17:13Z","timestamp":1787836633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_271_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/apc.apc_271_20","relation":{},"ISSN":["0974-2069","0974-5149"],"issn-type":[{"value":"0974-2069","type":"print"},{"value":"0974-5149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2020-12-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}