{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:23Z","timestamp":1786653563342,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      The diagnosis of long QT syndrome (LQTS)\n                      <jats:italic toggle=\"yes\">in utero<\/jats:italic>\n                      presents many challenges for clinicians, and there is high risk for intrauterine fetal demise as life-threatening arrhythmias develop secondary to QT prolongation. We describe a challenging case of a fetus presenting with sinus bradycardia and second-degree atrioventricular block with episodes of ventricular tachycardia. A prenatal diagnosis of LQTS was suspected given the fetal echocardiographic findings of a short ventricular relaxation time, due to extremely prolonged refractory period. The patient was delivered emergently due to Torsade's with hydrops, with ongoing arrhythmia despite medical management requiring implantation of pacemaker and sympathectomy. Early recognition of LQTS is important to optimize fetal survival with prompt medical management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_34_21","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:50:18Z","timestamp":1677113418000},"page":"64-66","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Congenital long QT syndrome"],"prefix":"10.4103","volume":"15","author":[{"given":"Aura Daniella","family":"Santi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240901","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-1172-3-18","article-title":"Congenital long QT syndrome","volume":"3","author":"Crotti","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"R2-12-20240901","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1161\/CIRCULATIONAHA.113.004840","article-title":"In utero diagnosis of long QT syndrome by magnetocardiography","volume":"128","author":"Cuneo","year":"2013","journal-title":"Circulation"},{"key":"R3-12-20240901","doi-asserted-by":"crossref","first-page":"29","DOI":"10.14797\/mdcj-10-1-29","article-title":"Genetics of long QT syndrome","volume":"10","author":"Tester","year":"2014","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"R4-12-20240901","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000339150","article-title":"Fetal presentation of long QT syndrome \u2013 Evaluation of prenatal risk factors: A systematic review","volume":"33","author":"Ishikawa","year":"2013","journal-title":"Fetal Diagn Ther"},{"key":"R5-12-20240901","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00246-018-1911-y","article-title":"A potential diagnostic approach for foetal long-QT syndrome, Developed and validated in children","volume":"39","author":"Vink","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"R6-12-20240901","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.hrcr.2017.04.007","article-title":"The diagnosis and management of long QT syndrome based on fetal echocardiography","volume":"3","author":"Blais","year":"2017","journal-title":"HeartRhythm Case Rep"},{"key":"R7-12-20240901","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1161\/CIRCULATIONAHA.112.114132","article-title":"Fetal heart rate predictors of long QT syndrome","volume":"126","author":"Mitchell","year":"2012","journal-title":"Circulation"},{"key":"R8-12-20240901","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1525-2167(03)00011-8","article-title":"Tissue Doppler echocardiography in patients with long QT syndrome","volume":"4","author":"Savoye","year":"2003","journal-title":"Eur J Echocardiogr"},{"key":"R9-12-20240901","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-1172-3-18","article-title":"Congenital long QT syndrome","volume":"3","author":"Crotti","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"R10-12-20240901","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.113.003985","article-title":"Long QT syndrome","volume":"129","author":"Abrams","year":"2014","journal-title":"Circulation"}],"container-title":["Annals of Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_34_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:22Z","timestamp":1786649962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/apc.apc_34_21"}},"subtitle":["A challenging diagnosis by fetal echocardiography"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/apc.apc_34_21","relation":{},"ISSN":["0974-2069"],"issn-type":[{"value":"0974-2069","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}