{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:44Z","timestamp":1787840684963,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Ventricular assist device\u00a0(VAD) implantation is an established treatment for infants with severe heart failure\u00a0(HF), serving as a bridge to heart transplantation or enabling myocardial recovery. This study aims to evaluate the probability of ventricular recovery following VAD support in infants with severe HF secondary to myocarditis. In addition, we analyze clinical experiences focusing on the weaning process, challenges during explantation, and outcomes, with special attention to a small cohort\u00a0(\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u00a0=\u00a04) to highlight specific findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>From 1988 to 2024, 63 consecutive pediatric HF patients were supported with VAD systems. This retrospective descriptive study includes four patients\u00a0(2016\u20132024) who achieved myocardial recovery and underwent VAD explantation. Weaning assessments included heart catheterization and echocardiography to determine suitability for VAD removal. One patient with congenital heart disease and severe HF was excluded due to prior reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four patients diagnosed with cardiomyopathy\u00a0\u2013\u00a0three with parvovirus B19 confirmed by polymerase chain reaction and one with arrhythmogenic cardiomyopathy\u00a0\u2013\u00a0received Berlin Heart\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Excor left VADs. Two children developed frequent valve thrombosis requiring pump replacement. All patients experienced mild-to-moderate neurological complications postimplantation. Renal and hepatic functions normalized by follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Myocardial recovery during VAD support is possible, particularly in children with severe myocarditis and cardiomyopathy. Concurrent HF medications alongside VAD support appear to promote recovery. Furthermore, VAD therapy improves systemic hemodynamics, contributing to normalization of renal and hepatic functions. These findings support the use of VADs for recovery in selected pediatric patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/apc.apc_79_25","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T18:00:24Z","timestamp":1756490424000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A single-center experience with recovery of heart function in children following ventricular assist device support"],"prefix":"10.4103","volume":"18","author":[{"given":"L. Lily","family":"Rosenthal","sequence":"first","affiliation":[{"name":"Division for Pediatric and Congenital Heart Surgery, LMU University, Munich, Germany"},{"name":"European Pediatric Heart Center Munich, Munich, Germany"},{"name":"Department of Congenital and Pediatric Heart Surgery, Technical University of Munich, German Heart Center Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Grinninger","sequence":"additional","affiliation":[{"name":"Department of Heart Surgery, LMU University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Dalla","family":"Pozza","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, LMU University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus A.","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, LMU University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"H\u00f6rer","sequence":"additional","affiliation":[{"name":"Division for Pediatric and Congenital Heart Surgery, LMU University, Munich, Germany"},{"name":"European Pediatric Heart Center Munich, Munich, Germany"},{"name":"Department of Congenital and Pediatric Heart Surgery, Technical University of Munich, German Heart Center Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Michel","sequence":"additional","affiliation":[{"name":"Division for Pediatric and Congenital Heart Surgery, LMU University, Munich, Germany"},{"name":"European Pediatric Heart Center Munich, Munich, Germany"},{"name":"Department of Congenital and Pediatric Heart Surgery, Technical University of Munich, German Heart Center Munich, Germany"},{"name":"Department for Cardiovascular Diseases, Munich Heart Alliance \u2013 DZHK, LMU University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hagl","sequence":"additional","affiliation":[{"name":"Department of Heart Surgery, LMU University, Munich, Germany"},{"name":"Department for Cardiovascular Diseases, Munich Heart Alliance \u2013 DZHK, LMU University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Schramm","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic- and Cardiovascular Surgery, Heart and Diabetes Center Northrhine Westfalia, Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Fischer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, LMU University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"e13548","DOI":"10.1111\/petr.13548","article-title":"Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry \u201cMYKKE\u201d","volume":"23","author":"Schubert","year":"2019","journal-title":"Pediatr Transplant"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"151","DOI":"10.21037\/tp.2019.04.09","article-title":"Pulmonary artery banding in dilative cardiomyopathy of young children: Review and protocol based on the current knowledge","volume":"8","author":"Schranz","year":"2019","journal-title":"Transl Pediatr"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.healun.2018.08.005","article-title":"Bridge 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heart EXCOR pediatrics-the SickKids experience 2004-2008","volume":"34","author":"Humpl","year":"2010","journal-title":"Artif Organs"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"148","DOI":"10.21037\/cdt-20-278","article-title":"Heart failure in the young: Insights into myocardial recovery with ventricular assist device support","volume":"11","author":"Javier Delmo","year":"2021","journal-title":"Cardiovasc Diagn Ther"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"ezae126","DOI":"10.1093\/ejcts\/ezae126","article-title":"Durable left ventricular assist device explantation following recovery in paediatric patients: Determinants and outcome after explantation","volume":"65","author":"Rohde","year":"2024","journal-title":"Eur J Cardiothorac Surg"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"ytae509","DOI":"10.1093\/ehjcr\/ytae509","article-title":"Mechanical circulatory support as bridge to recovery in an 8-year-old girl with tachycardia-induced cardiomyopathy due to atypical atrioventricular nodal re-entrant tachycardia: A case report","volume":"8","author":"Kahl","year":"2024","journal-title":"Eur Heart J Case Rep"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.healun.2013.01.988","article-title":"Pulmonary artery banding in infants and young children with left ventricular dilated cardiomyopathy: A novel therapeutic strategy before heart transplantation","volume":"32","author":"Schranz","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1747-0803.2011.00494.x","article-title":"Left ventricular assist device support as a bridge to recovery in young children","volume":"6","author":"Ihnat","year":"2011","journal-title":"Congenit Heart Dis"}],"container-title":["Annals of Pediatric 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History"}},{"value":"2025-06-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}