{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:30Z","timestamp":1791272310406,"version":"4.1.0"},"reference-count":96,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>\n                    Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that often occurs in patients with asthma or cystic fibrosis (CF) and is characterized by a hypersensitivity response to the allergens of the fungus\n                    <jats:italic toggle=\"yes\">Aspergillus fumigatus<\/jats:italic>\n                    . In patients with CF, growth of\n                    <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                    hyphae within the bronchial lumen triggers an immunoglobulin E (IgE)-mediated hypersensitivity response that results in airway inflammation, bronchospasm, and bronchiectasis. In most published studies, the prevalence of ABPA is about 8.9% in patients with CF. Since the clinical features of this condition overlap significantly with that of CF, ABPA is challenging to diagnose and remains underdiagnosed in many patients. Diagnosis of ABPA in CF patients should be sought in those with evidence of clinical and radiologic deterioration that is not attributable to another etiology, a markedly elevated total serum IgE level (while off steroid therapy) and evidence of\n                    <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                    sensitization. Management of ABPA involves the use of systemic steroids to reduce inflammation and modulate the immune response. In patients who do not respond to steroids or cannot tolerate them, antifungal agents should be used to reduce the burden of\n                    <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                    allergens. Recent studies suggest that omalizumab may be an effective option to reduce the frequency of ABPA exacerbations in patients with CF. Further randomized controlled trials are needed to better establish the efficacy of omalizumab in managing patients with CF and ABPA.\n                  <\/jats:p>","DOI":"10.4103\/atm.atm_231_16","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T03:00:24Z","timestamp":1491447624000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":59,"title":["Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis"],"prefix":"10.4103","volume":"12","author":[{"given":"Ibrahim Ahmed","family":"Janahi","sequence":"first","affiliation":[{"name":"Department of Clinical Pediatrics, Weill Cornell Medical College-Qtar, Doha, Qatar"},{"name":"Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamad Medical 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