{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:57Z","timestamp":1787169837520,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract:<\/jats:title>\n \n OBJECTIVES:<\/jats:title>\n The objectives of the study were to determine the clinicodemographic characteristics and the prognostic role of myasthenia gravis (MG) in thymoma.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n The records of patients who underwent surgical resection of thymoma at King Faisal Specialist Hospital and Research Center in the past 23 years were reviewed. Seventy thymoma patients were finally included and were then categorized based on MG status into the MG group (39 patients) and the non-MG group (31 patients). Collected data included patients\u2019 demographic characteristics, tumor characteristics, and postoperative clinical outcomes. All analyses were conducted using SPSS. The comparison between both groups was tested using the Student\n t<\/jats:italic>\n -test and Chi-square test for continuous and categorical variables, respectively. A\n P<\/jats:italic>\n = 0.05 or less indicated statistical significance.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Patients\u2019 age ranged from 11 to 76 years, and female predominance was observed (55.7%). Compared to the non-MG group, no difference in patients\u2019 gender was observed (\n P<\/jats:italic>\n = 0.058); however, MG patients had a younger age (39.30 vs. 48.77,\n P<\/jats:italic>\n = 0.0095). No difference was noted between both groups based on the World Health Organization classification (\n P<\/jats:italic>\n = 0.398), but MG patients tended to present with less-advanced tumors based on the TNM classification (\n P<\/jats:italic>\n = 0.039) and lower stage based on the MASAOKA staging system (\n P<\/jats:italic>\n = 0.017). No significant change in tumor size (\n P<\/jats:italic>\n = 0.077), resectability (\n P<\/jats:italic>\n = 0.507), and adjuvant therapy (\n P<\/jats:italic>\n = 0.075) were observed. MG was not significantly associated with postoperative complications, morbidity, or mortality. However, it exhibited a prognostic protective role in terms of lower recurrence (2.56% vs. 35.48%,\n P<\/jats:italic>\n = 0.0001) and longer survival duration (18.62 vs. 10.21 years,\n P<\/jats:italic>\n < 0.001) as compared to non-MG patients.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n MG occurrence in thymoma patients is more likely to occur at a younger age, higher TNM classification, and advanced MASAOKA stage. Although no significant association was noted between MG and complications and mortality, MG exhibited a protective role in thymoma by providing a lower recurrence rate and longer survival duration.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/atm.atm_61_23","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:12:38Z","timestamp":1697627558000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Clinicodemographic characteristics and prognostic role of myasthenia gravis in thymoma: Experience from a Saudi population"],"prefix":"10.4103","volume":"18","author":[{"given":"Abdullah Al","family":"Shammari","sequence":"first","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center, Alfaisal University, Riyadh, Saudi Arabia"},{"name":"Department of Thoracic Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama Tareq","family":"Saif","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safy A.","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad J.","family":"Ghosheh","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi 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