{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:28Z","timestamp":1787761948343,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"\n Background:<\/jats:title>\n \n The four essential factors of conception are\n Ritu<\/jats:italic>\n (optimum period for conception),\n Kshetra<\/jats:italic>\n (place of conception),\n Ambu<\/jats:italic>\n (nutrition), and\n Beeja<\/jats:italic>\n (healthy sperm and ovum).\n Kshetra<\/jats:italic>\n denotes body as general and to be very specific, especially about the female reproductive system, it is\n Garbhashaya<\/jats:italic>\n or the uterine cavity and function is\n Garbhadhana<\/jats:italic>\n or conception. The endometrial factor is an important subset in infertility due to poor implantation.\n <\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n To evaluate the efficacy of\n Saubhagyanandana Ghrita Yonipichu<\/jats:italic>\n (vaginal tampoon) and\n Jeevaniya Churna<\/jats:italic>\n orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods:<\/jats:title>\n \n It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (\n n<\/jats:italic>\n = 15) was given\n Saubhagyanandana Ghrita Yonipichu<\/jats:italic>\n (10 mL for 6 days after cessation of menses, for 1 cycle) along with\n Jeevaniya Churna<\/jats:italic>\n orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Results were analyzed by the paired'\n t<\/jats:italic>\n -test for the objective parameters and Wilcoxon signed rank\u2013sum test for the subjective parameters. A statistically highly significant difference (\n P<\/jats:italic>\n < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (\n P<\/jats:italic>\n < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (\n P<\/jats:italic>\n < 0.001) was found in ovulation. One of the patients conceived after the treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Saubhagyanandana Ghrita Yonipichu<\/jats:italic>\n (vaginal tampoon) and\n Jeevaniya Churna<\/jats:italic>\n orally are effective in improving the thin endometrium.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ayu.ayu_132_21","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:33:40Z","timestamp":1684294420000},"page":"156-163","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Management of Vandhyatva w.s.r. to thin endometrium through Ayurveda- A single arm open labelled pilot clinical trial"],"prefix":"10.4103","volume":"42","author":[{"given":"Jalpa Deepak","family":"Rupareliya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Donga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay Jayprakash","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R3-3-20240901","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0020-7292(94)90230-5","article-title":"Infertility: An international health problem","volume":"46","author":"Sciarra","year":"1994","journal-title":"Int J Gynaecol Obstet"},{"key":"R4-3-20240901","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0897.2009.00792.x","article-title":"Inflammation and implantation","volume":"63","author":"Dekel","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"R5-3-20240901","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1477-7827-12-96","article-title":"Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration","volume":"12","author":"Wu","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"R12-3-20240901","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s13224-015-0742-5","article-title":"Ultrasonography and Doppler study to predict uterine receptivity in infertile patients undergoing embryo transfer","volume":"66","author":"Khan","year":"2016","journal-title":"J Obstet Gynaecol India"},{"key":"R13-3-20240901","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0015-0282(01)01823-4","article-title":"Factors useful in predicting the success of oocyte donation: A 3-year retrospective analysis","volume":"76","author":"Noyes","year":"2001","journal-title":"Fertil Steril"},{"key":"R15-3-20240901","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/gme.0b013e318186d7e2","article-title":"Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: A 2-year randomized, double-blind, placebo-controlled study","volume":"16","author":"D'Anna","year":"2009","journal-title":"Menopause"}],"container-title":["AYU (An International Quarterly Journal of Research in Ayurveda)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ayu.ayu_132_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:08:43Z","timestamp":1787760523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ayu.ayu_132_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ayu.ayu_132_21","relation":{},"ISSN":["0974-8520"],"issn-type":[{"value":"0974-8520","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}