{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:48Z","timestamp":1787169648959,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Introduction:<\/jats:title>\n \n Aragvadhadi Taila<\/jats:italic>\n (ART) is one of the herbomineral formulations mentioned in Chakradatta indicated in\n Shwitra<\/jats:italic>\n (vitiligo). Modification of\n Taila<\/jats:italic>\n form into gel form reduces the risk of contamination in view of arsenical contents (\n Manahshila<\/jats:italic>\n ,\n Haratala<\/jats:italic>\n ) assures precise dose administration at desired site (by avoiding spreading). The gel is a comparatively acceptable dosage form than that of medicated oil.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n The aim of the study is to evaluate the comparative efficacy of\n Aragvadhadi<\/jats:italic>\n formulation in\n Taila<\/jats:italic>\n (ART:\n Aragvadhadi Taila<\/jats:italic>\n ) and gel (ARG:\n Aragvadhadi<\/jats:italic>\n gel) dosage forms with the internal administration of\n Rasayana Churna<\/jats:italic>\n in the management of\n Shwitra<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods:<\/jats:title>\n \n The study was a randomized open labeled, involving 66 patients of\n Shwitra<\/jats:italic>\n that were randomly divided into two groups. Patients registered in group A (\n n<\/jats:italic>\n = 34) were treated with local applications of ART and group B (\n n<\/jats:italic>\n = 32) with ARG for 2 months.\n Rasayana Churna<\/jats:italic>\n (3 g), along with the equal quantity of honey and\n Ghrita<\/jats:italic>\n was given twice a day after the meal in both groups. Wilcoxon signed-rank test was applied to evaluate the effect of therapy in the individual group for subjective criteria like vitiligo area scoring index score, size and number of patches,\n Rukshata<\/jats:italic>\n (dryness),\n Saparidaha<\/jats:italic>\n (burning sensation),\n Bahalatva<\/jats:italic>\n (thickening),\n Kandu<\/jats:italic>\n (itching) while the comparison of results between the groups for the same by applying Coefficient of Variation (CV).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Group B showed better and consistent results in all signs and symptoms except\n Rukshata, Saparidaha<\/jats:italic>\n in terms of Coefficient of Variation. In both the groups, statistically highly significant improvement was found in signs and symptoms of\n Shwitra<\/jats:italic>\n such as\n Saparidaha, Kandu<\/jats:italic>\n , size of patches and number of patches; however, the difference between the groups was statistically insignificant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Both the forms (ART, ARG) of\n Aragvadhadi<\/jats:italic>\n formulation along with\n Rasayana Churna<\/jats:italic>\n were found as a safe and effective treatment in vitiligo with significant pigment regeneration capacity as topical use for application over 2 months.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ayu.ayu_323_20","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T05:49:47Z","timestamp":1679809787000},"page":"19-29","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of external application of oil and gel dosage forms of Aragvadhadi formulation in combination with Rasayana Churna in the management of Shwitra (vitiligo) - An open-labeled comparative clinical trial"],"prefix":"10.4103","volume":"42","author":[{"given":"Sarika","family":"Makwana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipali","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Bedarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajyoti","family":"Patgiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-2-20240901","first-page":"100","article-title":"Vitiligo: Clinical profiles in vadodara","volume":"51","author":"Shajil","year":"2006","journal-title":"Int J Dermatol"},{"key":"R3-2-20240901","first-page":"15","article-title":"Advances in 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