{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:13Z","timestamp":1786649653372,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Thoracic aortic ischemia-reperfusion (I\/R) injury occurs in clinical scenarios and can lead to damage in organs such as the spinal cord, kidneys, and intestines. Hypoxic postconditioning (HyP) has shown promise in reducing organ I\/R injury, suggesting its potential applicability in thoracic aortic I\/R injury. However, the pathological damage caused by thoracic aorta occlusion (TAO) to the heart and brain is not yet well understood. This study aims to investigate the protective effects of hypoxic conditioning (HyP) treatment on brain and cardiac tissues following TAO-induced I\/R injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Male C57BL\/6 mice were used to construct the TAO model by blocking the thoracic aorta for 0.5 or 1 h, followed by 24 h of reperfusion. The mice were divided into five groups: sham, TAO (0.5 h), TAO (0.5 h) +HyP, TAO (1 h), and TAO (1 h) +HyP. Hematoxylin and eosin, Masson, and Sirius red staining were performed to assess morphological changes and collagen deposition in brain and heart tissues. Protein expression assays were conducted to quantify inflammation-related proteins in the serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The results showed that TAO caused significant neuronal damage in the hippocampal regions (CA1, CA3, and DG) and myocardial cell damage with collagen deposition. HyP treatment significantly alleviated these damages, particularly with shorter ischemic durations (0.5 h). Specifically, in cardiac tissues, HyP treatment reduced myocardial injury and collagen deposition. In addition, HyP treatment modulated systemic inflammatory responses, as evidenced by the increased expression of anti-inflammatory proteins such as interleukin 13 (IL-13) and the decreased expression of pro-inflammatory proteins such as IL-6, IL-12p70, IL-17, and tumor necrosis factor-\u03b1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>HyP treatment significantly mitigates brain and cardiac tissue damage caused by TAO, especially with shorter ischemic durations. These findings highlight the potential clinical application of HyP treatment in reducing TAO-induced tissue damage and inflammation, offering a novel therapeutic option for patients with thoracic aortic I\/R injury. Future studies should further investigate the mechanisms and optimal implementation protocols of HyP treatment to maximize its clinical value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/bc.bc_133_24","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T20:33:52Z","timestamp":1742675632000},"page":"64-76","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Protective effects of hypoxic conditioning treatment on brain and cardiac tissues following thoracic aorta occlusion"],"prefix":"10.4103","volume":"11","author":[{"given":"Jun","family":"Xu","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Hypoxia Conditioning Translational Laboratory of Clinical Medicine, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tong","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Hypoxia Conditioning Translational Laboratory of Clinical Medicine, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Department of Interventional Radiology, Senior Department of Oncology, Fifth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Hypoxia Conditioning Translational Laboratory of Clinical Medicine, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Hypoxia Conditioning Translational Laboratory of Clinical Medicine, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Senior Department of Oncology, Fifth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Senior Department of Oncology, Fifth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Hypoxia Conditioning Translational Laboratory of Clinical Medicine, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing, China"},{"name":"Hypoxia Conditioning Translational Laboratory of Clinical Medicine, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"R1-20250324","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1097\/00003246-200009000-00044","article-title":"Thoracoabdominal aortic aneurysm repair: A human model of ischemia\/reperfusion-induced cytokine-driven multiple organ dysfunction syndrome","volume":"28","author":"Fink","year":"2000","journal-title":"Crit Care Med"},{"key":"R2-20250324","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/cells10051231","article-title":"Conditioned medium from mesenchymal stem cells alleviates endothelial dysfunction of vascular grafts submitted to ischemia\/reperfusion injury in 15-Month-old rats","volume":"10","author":"Korkmaz-Ic\u00f6z","year":"2021","journal-title":"Cells"},{"key":"R3-20250324","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13017-023-00484-w","article-title":"Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room","volume":"18","author":"Balch","year":"2023","journal-title":"World J Emerg Surg"},{"key":"R4-20250324","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/bc.bc_9_24","article-title":"Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke","volume":"10","author":"Elmadhoun","year":"2024","journal-title":"Brain Circ"},{"key":"R5-20250324","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.2016152222","article-title":"Spinal cord inflammation: Molecular imaging after thoracic aortic ischemia reperfusion injury","volume":"282","author":"Albadawi","year":"2017","journal-title":"Radiology"},{"key":"R6-20250324","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jvs.2010.03.021","article-title":"The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion","volume":"52","author":"Kang","year":"2010","journal-title":"J Vasc Surg"},{"key":"R7-20250324","first-page":"326","article-title":"Kidney protection in thoracoabdominal aortic aneurysm surgery","volume":"62","author":"Loschi","year":"2021","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"R8-20250324","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/bc.bc_24_24","article-title":"The impact of high-altitude and cold environment on brain and heart damage in rats with hemorrhagic shock","volume":"10","author":"Xu","year":"2024","journal-title":"Brain Circ"},{"key":"R9-20250324","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","article-title":"A cellular perspective on brain energy metabolism and functional imaging","volume":"86","author":"Magistretti","year":"2015","journal-title":"Neuron"},{"key":"R10-20250324","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/cvr\/cvab246","article-title":"Functional and structural adaptations of the coronary macro-and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC working group on coronary pathophysiology and microcirculation position paper","volume":"118","author":"Koller","year":"2022","journal-title":"Cardiovasc Res"},{"key":"R11-20250324","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","article-title":"Neuronal regulation of the blood-brain barrier and neurovascular coupling","volume":"21","author":"Kaplan","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"R12-20250324","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.jvs.2015.06.214","article-title":"Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice","volume":"64","author":"Nguyen","year":"2016","journal-title":"J Vasc Surg"},{"key":"R13-20250324","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.semtcvs.2019.02.025","article-title":"Spinal cord protection for thoracic aortic surgery: Bench to bedside","volume":"31","author":"Ghincea","year":"2019","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"R14-20250324","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3390\/jpm12101629","article-title":"Prevention of spinal cord injury during thoracoabdominal aortic aneurysms repair: What the anaesthesiologist should know","volume":"12","author":"Marturano","year":"2022","journal-title":"J Pers Med"},{"key":"R15-20250324","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1053\/j.jvca.2020.11.035","article-title":"Brain protection in aortic arch surgery: An evolving field","volume":"35","author":"Qu","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R16-20250324","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pneurobio.2017.01.001","article-title":"Preconditioning in neuroprotection: From hypoxia to ischemia","volume":"157","author":"Li","year":"2017","journal-title":"Prog Neurobiol"},{"key":"R17-20250324","first-page":"370","article-title":"Effects of hypoxia on cerebral microvascular angiogenesis: Benefits or damages?","volume":"14","author":"Guan","year":"2023","journal-title":"Aging Dis"},{"key":"R18-20250324","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.14336\/AD.2023.0424","article-title":"Hypoxia and the aging cardiovascular system","volume":"14","author":"Raberin","year":"2023","journal-title":"Aging Dis"},{"key":"R19-20250324","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1152\/ajpheart.00060.2018","article-title":"Cardioprotection by intermittent hypoxia conditioning: Evidence, mechanisms, and therapeutic potential","volume":"315","author":"Mallet","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R20-20250324","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3389\/fimmu.2018.02819","article-title":"Metabolic, mental and immunological effects of normoxic and hypoxic training in multiple sclerosis patients: A pilot study","volume":"9","author":"M\u00e4hler","year":"2018","journal-title":"Front Immunol"},{"key":"R21-20250324","doi-asserted-by":"crossref","first-page":"1533317519896725","DOI":"10.1177\/1533317519896725","article-title":"Intermittent hypoxia training for treating mild cognitive impairment: A pilot study","volume":"35","author":"Wang","year":"2020","journal-title":"Am J Alzheimers dis other demen"},{"key":"R22-20250324","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1212\/WNL.0000000000004596","article-title":"Effects of acute intermittent hypoxia on hand use after spinal cord trauma: A preliminary study","volume":"89","author":"Trumbower","year":"2017","journal-title":"Neurology"},{"key":"R23-20250324","first-page":"2863","article-title":"Hypoxic conditioning: A potential perioperative strategy to reduce abdominal aortic occlusion-related injury in mouse proximal and distal organs","volume":"15","author":"Ren","year":"2024","journal-title":"Aging Dis"},{"key":"R24-20250324","doi-asserted-by":"crossref","first-page":"e14346","DOI":"10.1111\/cns.14346","article-title":"Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke","volume":"30","author":"Zhang","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"R25-20250324","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/jnen\/nlab084","article-title":"Histological findings after aortic cross-clamping in preclinical animal models","volume":"80","author":"Awad","year":"2021","journal-title":"J Neuropathol Exp Neurol"},{"key":"R26-20250324","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0300-9572(85)90024-3","article-title":"Cerebral blood flow during open-chest cardiac massage with occlusion of the descending aorta in dogs","volume":"13","author":"Suzuki","year":"1985","journal-title":"Resuscitation"},{"key":"R27-20250324","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/BF01616836","article-title":"The effect of nitecapone, a new antioxidant, on myocardial function after aortic cross-clamping in experimental heart ischemia","volume":"8","author":"Vento","year":"1999","journal-title":"Int J Angiol"},{"key":"R28-20250324","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1748-1716.1987.tb08098.x","article-title":"Conditions for increased cardiac output during occlusion of the descending thoracic aorta","volume":"129","author":"Vengen","year":"1987","journal-title":"Acta Physiol Scand"},{"key":"R29-20250324","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/ejcts\/ezab381","article-title":"Protective effects of 17b-oestradiol on coagulation and systemic inflammation after total occlusion of the descending aorta in male rats","volume":"61","author":"Sobral","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"key":"R30-20250324","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0022-5223(19)36824-2","article-title":"Hemodynamics and oxygen uptake below and above aortic occlusion during crossclamping of the thoracic aorta and sodium nitroprusside infusion","volume":"100","author":"Gregoretti","year":"1990","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R31-20250324","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/SHK.0000000000001946","article-title":"Whole blood selective aortic arch perfusion for exsanguination cardiac arrest: Assessing myocardial tolerance to the duration of cardiac arrest","volume":"57","author":"Madurska","year":"2022","journal-title":"Shock"},{"key":"R32-20250324","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/jnc.15498","article-title":"Does the inability of CA1 area to respond to ischemia with early rapid adenosine release contribute to hippocampal vulnerability? An editorial highlight for \u201cSpontaneous, transient adenosine release is not enhanced in the CA1 region of hippocampus during severe ischemia models\u201d","volume":"159","author":"Gulyaeva","year":"2021","journal-title":"J Neurochem"},{"key":"R33-20250324","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.CIR.0000084550.16565.01","article-title":"Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair","volume":"108","author":"Fiane","year":"2003","journal-title":"Circulation"},{"key":"R34-20250324","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/bc.bc_18_17","article-title":"Neuroinflammation in traumatic brain injury: A chronic response to an acute injury","volume":"3","author":"Schimmel","year":"2017","journal-title":"Brain Circ"},{"key":"R35-20250324","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jss.2014.04.012","article-title":"The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock","volume":"191","author":"Morrison","year":"2014","journal-title":"J Surg Res"},{"key":"R36-20250324","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/bc.bc_50_23","article-title":"Risk factors for intraprocedural hypoxemia in patients with acute cerebral ischemia treated with vascular intervention and its impact on prognosis: A retrospective cohort study","volume":"10","author":"Gu","year":"2024","journal-title":"Brain Circ"}],"container-title":["Brain Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_133_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:35Z","timestamp":1786647395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_133_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/bc.bc_133_24","relation":{},"ISSN":["2394-8108","2455-4626"],"issn-type":[{"value":"2394-8108","type":"print"},{"value":"2455-4626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}