{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:45:27Z","timestamp":1786718727860,"version":"build-2736575974"},"reference-count":105,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Circ"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/bc.bc_13_18","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:07:35Z","timestamp":1546214855000},"page":"174","source":"Crossref","is-referenced-by-count":31,"title":["Effects of three flavonoids from an ancient traditional Chinese medicine Radix puerariae on geriatric diseases"],"prefix":"10.4103","volume":"4","author":[{"given":"Yumin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2394-8108.249037-1","first-page":"708","volume-title":"Ginseng: An nonnegligible natural remedy for healthy aging","author":"Yang","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-2","first-page":"868","volume-title":"Anti-aging implications of Astragalus membranaceus (Huangqi): A well-known Chinese tonic","author":"Liu","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-3","first-page":"691","volume-title":"Emerging roles of Ganoderma lucidum in anti-aging","author":"Wang","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-4","first-page":"740","volume-title":"Herba cistanches: Anti-aging","author":"Wang","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-5","first-page":"778","volume-title":"Lycium barbarum: A traditional Chinese herb and A promising anti-aging agent","author":"Gao","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-6","first-page":"827","volume-title":"Dendrobium: sources of active ingredients to treat age-related pathologies","author":"Cakova","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-7","first-page":"760","volume-title":"Rhizoma coptidis and berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation","author":"Xu","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-8","first-page":"721","volume-title":"Therapeutic potential and cellular mechanisms of panax notoginseng on prevention of aging and cell senescence-associated diseases","author":"Zhao","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-9","first-page":"812","volume-title":"Advances in the studies of Ginkgo biloba leaves extract on aging-related diseases","author":"Zuo","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-10","first-page":"850","volume-title":"The effects of baicalin and baicalein on cerebral ischemia: A review","author":"Liang","year":"2017","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-11","first-page":"787","volume-title":"Radix puerariae: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","author":"Zhang","year":"2013","journal-title":"J Clin Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-12","first-page":"2827","volume-title":"Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction","author":"Hu","year":"2008","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"key-10.4103\/2394-8108.249037-13","first-page":"270","volume-title":"Genistein ameliorates learning and memory deficits in amyloid \u03b2(1-40) rat model of Alzheimer's disease","author":"Bagheri","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"key-10.4103\/2394-8108.249037-14","first-page":"39","volume-title":"Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia","author":"Liu","year":"2014","journal-title":"Neurochem Int"},{"key":"key-10.4103\/2394-8108.249037-15","first-page":"466","volume-title":"Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice","author":"Ropelle","year":"2013","journal-title":"Diabetes"},{"key":"key-10.4103\/2394-8108.249037-16","first-page":"324","volume-title":"Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats","author":"Yan","year":"2006","journal-title":"Life Sci"},{"key":"key-10.4103\/2394-8108.249037-17","first-page":"1806","volume-title":"Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats","author":"Palanisamy","year":"2013","journal-title":"Br J Nutr"},{"key":"key-10.4103\/2394-8108.249037-18","first-page":"133","volume-title":"Acomparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis","author":"Jiang","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/2394-8108.249037-19","first-page":"584","volume-title":"Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases","author":"Wong","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/2394-8108.249037-20","first-page":"166","volume-title":"Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice","author":"Zhao","year":"2015","journal-title":"Neurotoxicology"},{"key":"key-10.4103\/2394-8108.249037-21","first-page":"635","volume-title":"Puerarin alleviates cognitive impairment and oxidative stress in APP\/PS1 transgenic mice","author":"Zhou","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"key-10.4103\/2394-8108.249037-22","first-page":"30","volume-title":"Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways","author":"Zhang","year":"2011","journal-title":"Exp Gerontol"},{"key":"key-10.4103\/2394-8108.249037-23","doi-asserted-by":"crossref","unstructured":"Jiang M, Yun Q, Niu G, Gao Y, Shi F, Yu S, et al. Puerarin prevents inflammation and apoptosis in the neurocytes of a murine Parkinson's disease model. Genet Mol Res 2016;15: gmr.15047501.","DOI":"10.4238\/gmr.15047501"},{"key":"key-10.4103\/2394-8108.249037-24","first-page":"179","volume-title":"Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice","author":"Zhu","year":"2014","journal-title":"Phytother Res"},{"key":"key-10.4103\/2394-8108.249037-25","first-page":"336","volume-title":"Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of bFGF in the 6-OHDA-induced Parkinson's disease model","author":"Cai","year":"2016","journal-title":"Aging Dis"},{"key":"key-10.4103\/2394-8108.249037-26","first-page":"52","volume-title":"Involvement of ubiquitin proteasome system in protective mechanisms of puerarin to MPP(+)-elicited apoptosis","author":"Cheng","year":"2009","journal-title":"Neurosci Res"},{"key":"key-10.4103\/2394-8108.249037-27","first-page":"157","volume-title":"Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats","author":"Wu","year":"2014","journal-title":"Indian J Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0253-7613","issn-type":"print"},{"key":"key-10.4103\/2394-8108.249037-28","first-page":"282","volume-title":"Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"key":"key-10.4103\/2394-8108.249037-29","first-page":"367","volume-title":"Lyophilized powder of catalpol and puerarin protects neurovascular unit from stroke","author":"Xue","year":"2016","journal-title":"Int J Biol Sci"},{"key":"key-10.4103\/2394-8108.249037-30","first-page":"4695","volume-title":"Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia","author":"Zhang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"key-10.4103\/2394-8108.249037-31","doi-asserted-by":"crossref","unstructured":"Ling C, Liang J, Zhang C, Li R, Mou Q, Qin J, et al. Synergistic effects of salvianolic acid B and puerarin on cerebral ischemia reperfusion injury. Molecules 2018;23. pii: E564.","DOI":"10.3390\/molecules23030564"},{"key":"key-10.4103\/2394-8108.249037-32","first-page":"614","volume-title":"A clinical efficacy and safety study on coronary heart disease and angina treatment with puerarin injection","author":"Luo","year":"2012","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"key-10.4103\/2394-8108.249037-33","first-page":"14577","volume-title":"Puerarin injection for treatment of unstable angina pectoris: A meta-analysis and systematic review","author":"Gao","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key-10.4103\/2394-8108.249037-34","first-page":"CD004196","volume-title":"Puerarin injection for unstable angina pectoris","author":"Wang","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"key-10.4103\/2394-8108.249037-35","first-page":"637","volume-title":"Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris","author":"Yang","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"key-10.4103\/2394-8108.249037-36","first-page":"1413","volume-title":"Tissue distribution of PEGylated puerarin in acute myocardial ischemia mode rats","author":"Xia","year":"2014","journal-title":"Yao Xue Xue Bao"},{"key":"key-10.4103\/2394-8108.249037-37","first-page":"179","volume-title":"Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin","author":"Gao","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-38","first-page":"373","volume-title":"The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction","author":"Zhang","year":"2008","journal-title":"J Asian Nat Prod Res"},{"key":"key-10.4103\/2394-8108.249037-39","first-page":"652","volume-title":"Protective roles of puerarin and danshensu on acute ischemic myocardial injury in rats","author":"Wu","year":"2007","journal-title":"Phytomedicine"},{"key":"key-10.4103\/2394-8108.249037-40","first-page":"58","volume-title":"Puerarin protects against endothelial dysfunction and end-organ damage in ang II-induced hypertension","author":"Li","year":"2017","journal-title":"Clin Exp Hypertens"},{"key":"key-10.4103\/2394-8108.249037-41","first-page":"1685","volume-title":"Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction ventricular remodeling","author":"Kohno","year":"2008","journal-title":"Circ J"},{"key":"key-10.4103\/2394-8108.249037-42","first-page":"737","volume-title":"Effects of puerarin on expression of cardiac smad3 and smad7 mRNA in spontaneously hypertensive rat","author":"Zhang","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/2394-8108.249037-43","first-page":"908","volume-title":"Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy","author":"Liu","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/2394-8108.249037-44","first-page":"463","volume-title":"Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1\/2, p38 and NF-\u03baB pathways","author":"Chen","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"key-10.4103\/2394-8108.249037-45","first-page":"235","volume-title":"Puerarin suppresses angiotensin II-induced cardiac hypertrophy by inhibiting NADPH oxidase activation and oxidative stress-triggered AP-1 signaling pathways","author":"Gang","year":"2015","journal-title":"J Pharm Pharm Sci"},{"key":"key-10.4103\/2394-8108.249037-46","first-page":"73","volume-title":"Puerarin attenuates pressure overload-induced cardiac hypertrophy","author":"Yuan","year":"2014","journal-title":"J Cardiol"},{"key":"key-10.4103\/2394-8108.249037-47","first-page":"346","volume-title":"Aging and insulin resistance: Just say iNOS","author":"Evans","year":"2013","journal-title":"Diabetes"},{"key":"key-10.4103\/2394-8108.249037-48","first-page":"361","volume-title":"Puerarin protects pancreatic \u03b2-cells in obese diabetic mice via activation of GLP-1R signaling","author":"Yang","year":"2016","journal-title":"Mol Endocrinol"},{"key":"key-10.4103\/2394-8108.249037-49","first-page":"71","volume-title":"Puerarin protects pancreatic \u03b2-cell survival via PI3K\/Akt signaling pathway","author":"Li","year":"2014","journal-title":"J Mol Endocrinol"},{"key":"key-10.4103\/2394-8108.249037-50","first-page":"1815","volume-title":"The effect of puerarin against IL-1\u03b2-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2)","author":"Zhu","year":"2014","journal-title":"Mol Vis"},{"key":"key-10.4103\/2394-8108.249037-51","first-page":"485927","volume-title":"Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord","author":"Liu","year":"2014","journal-title":"Mediators Inflamm"},{"key":"key-10.4103\/2394-8108.249037-52","first-page":"9","volume-title":"Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy","author":"Li","year":"2009","journal-title":"Natl Med J India","ISSN":"https:\/\/id.crossref.org\/issn\/0970-258X","issn-type":"print"},{"key":"key-10.4103\/2394-8108.249037-53","first-page":"2229","volume-title":"Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats","author":"Shen","year":"2009","journal-title":"Mol Biol Rep"},{"key":"key-10.4103\/2394-8108.249037-54","first-page":"414","volume-title":"Epidemiologic characteristics of dyslipidemia in Chinese adults 2010","author":"Li","year":"2012","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"key-10.4103\/2394-8108.249037-55","first-page":"20","volume-title":"Coadministration of puerarin (low dose) and zinc attenuates bone loss and suppresses bone marrow adiposity in ovariectomized rats","author":"Liu","year":"2016","journal-title":"Life Sci"},{"key":"key-10.4103\/2394-8108.249037-56","first-page":"2562","volume-title":"Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma","author":"Guo","year":"2015","journal-title":"Mol Med Rep"},{"key":"key-10.4103\/2394-8108.249037-57","first-page":"2535","volume-title":"Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer","author":"Wang","year":"2014","journal-title":"Mol Med Rep"},{"key":"key-10.4103\/2394-8108.249037-58","first-page":"2752","volume-title":"Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells","author":"Zhang","year":"2014","journal-title":"Mol Med Rep"},{"key":"key-10.4103\/2394-8108.249037-59","first-page":"728","volume-title":"In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity","author":"Wang","year":"2013","journal-title":"Int J Pharm"},{"key":"key-10.4103\/2394-8108.249037-60","first-page":"918","volume-title":"Molecular mechanism of suppression of MDR1 by puerarin from pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7\/adr cells","author":"Hien","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"key-10.4103\/2394-8108.249037-61","doi-asserted-by":"crossref","unstructured":"Zhou YX, Zhang H, Peng C. Puerarin: A review of pharmacological effects. Phytother Res 2014;28:961-75.","DOI":"10.1002\/ptr.5083"},{"key":"key-10.4103\/2394-8108.249037-62","first-page":"184","volume-title":"Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis","author":"Hou","year":"2011","journal-title":"Chem Biol Interact"},{"key":"key-10.4103\/2394-8108.249037-63","first-page":"1311","volume-title":"Genistein exerts neuroprotective effect on focal cerebral ischemia injury in rats","author":"Aras","year":"2015","journal-title":"Inflammation"},{"key":"key-10.4103\/2394-8108.249037-64","first-page":"634","volume-title":"Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS\/Nrf2\/HO-1 signaling","author":"Wang","year":"2013","journal-title":"Hippocampus"},{"key":"key-10.4103\/2394-8108.249037-65","first-page":"88","volume-title":"Improvement of the circulatory function partially accounts for the neuroprotective action of the phytoestrogen genistein in experimental ischemic stroke","author":"Cortina","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-66","first-page":"5559","volume-title":"Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice","author":"Qin","year":"2015","journal-title":"Br J Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-67","first-page":"183","volume-title":"Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: Involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity","author":"Vera","year":"2007","journal-title":"Clin Sci (Lond)"},{"key":"key-10.4103\/2394-8108.249037-68","first-page":"1114","volume-title":"Acombination of intravenous genistein plus mg2+enhances antihypertensive effects in SHR by endothelial protection and BKCa channel inhibition","author":"Sun","year":"2015","journal-title":"Am J Hypertens"},{"key":"key-10.4103\/2394-8108.249037-69","first-page":"396","volume-title":"Genistein reduces hyperglycemia and islet cell loss in a high-dosage manner in rats with alloxan-induced pancreatic damage","author":"Yang","year":"2011","journal-title":"Pancreas"},{"key":"key-10.4103\/2394-8108.249037-70","first-page":"3026","volume-title":"Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice","author":"Fu","year":"2010","journal-title":"Endocrinology"},{"key":"key-10.4103\/2394-8108.249037-71","first-page":"2033","volume-title":", Liou GI.Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation","author":"Ibrahim","year":"2010","journal-title":"Mol Vis"},{"key":"key-10.4103\/2394-8108.249037-72","first-page":"63","volume-title":"Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats","author":"Gupta","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"key-10.4103\/2394-8108.249037-73","first-page":"112","volume-title":"Chronic administration of daidzein, a soybean isoflavone, improves endothelial dysfunction and attenuates oxidative stress in streptozotocin-induced diabetic rats","author":"Roghani","year":"2013","journal-title":"Phytother Res"},{"key":"key-10.4103\/2394-8108.249037-74","first-page":"724","volume-title":"Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice","author":"Babu","year":"2012","journal-title":"J Nutr"},{"key":"key-10.4103\/2394-8108.249037-75","first-page":"88","volume-title":"Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1\/iNOS pathway in type 1 diabetes","author":"Tie","year":"2013","journal-title":"J Nutr Biochem"},{"key":"key-10.4103\/2394-8108.249037-76","first-page":"7929","volume-title":"Effects of dietary genistein on plasma and liver lipids, hepatic gene expression, and plasma metabolic profiles of hamsters with diet-induced hyperlipidemia","author":"Tang","year":"2015","journal-title":"J Agric Food Chem"},{"key":"key-10.4103\/2394-8108.249037-77","first-page":"233","volume-title":"Effect of 7-difluoromethyl-5, 4'-dimethoxygenistein on aorta atherosclerosis in hyperlipidemia apoE(-\/-) mice induced by a cholesterol-rich diet","author":"Zhang","year":"2013","journal-title":"Drug Des Devel Ther"},{"key":"key-10.4103\/2394-8108.249037-78","first-page":"412","volume-title":"7-difluoromethyl-5,4'-dimethoxygenistein, a novel genistein derivative, has therapeutic effects on atherosclerosis in a rabbit model","author":"Zhao","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-79","first-page":"715","volume-title":"OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration","author":"Marini","year":"2008","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/2394-8108.249037-80","first-page":"127","volume-title":"Genistein induces apoptosis by down-regulating thioredoxin-1 in human hepatocellular carcinoma SNU-449 cells","author":"Roh","year":"2016","journal-title":"Food Chem Toxicol"},{"key":"key-10.4103\/2394-8108.249037-81","first-page":"74","volume-title":"Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of akt in colorectal cancer cells","author":"Qin","year":"2016","journal-title":"Pharm Biol"},{"key":"key-10.4103\/2394-8108.249037-82","first-page":"17870","volume-title":"Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-\u03b2-catenin axis","author":"Du","year":"2016","journal-title":"Oncotarget"},{"key":"key-10.4103\/2394-8108.249037-83","first-page":"1016","volume-title":"Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells","author":"Fang","year":"2016","journal-title":"Int J Oncol"},{"key":"key-10.4103\/2394-8108.249037-84","first-page":"94","volume-title":"The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase","author":"Wu","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-85","first-page":"1627","volume-title":"Genistein inhibits the proliferation of human multiple myeloma cells through suppression of nuclear factor-\u03baB and upregulation of microRNA-29b","author":"Xie","year":"2016","journal-title":"Mol Med Rep"},{"key":"key-10.4103\/2394-8108.249037-86","first-page":"3167","volume-title":"Genistein suppresses growth of human uterine sarcoma cell lines via multiple mechanisms","author":"Yeh","year":"2015","journal-title":"Anticancer Res"},{"key":"key-10.4103\/2394-8108.249037-87","first-page":"62","volume-title":"Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation","author":"Mahmoud","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key-10.4103\/2394-8108.249037-88","first-page":"209","volume-title":"Genome-wide DNA methylation modified by soy phytoestrogens: Role for epigenetic therapeutics in prostate cancer?","author":"Karsli-Ceppioglu","year":"2015","journal-title":"OMICS"},{"key":"key-10.4103\/2394-8108.249037-89","first-page":"154","volume-title":"Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of genistein","author":"de","year":"2016","journal-title":"Nutr Cancer"},{"key":"key-10.4103\/2394-8108.249037-90","first-page":"1157","volume-title":"7-difluoromethoxyl-5,4'-di-n-octyl genistein inhibits the stem-like characteristics of gastric cancer stem-like cells and reverses the phenotype of epithelial-mesenchymal transition in gastric cancer cells","author":"Cao","year":"2016","journal-title":"Oncol Rep"},{"key":"key-10.4103\/2394-8108.249037-91","first-page":"623","volume-title":"Genistein regulates tumor microenvironment and exhibits anticancer effect in dimethyl hydrazine-induced experimental colon carcinogenesis","author":"Sekar","year":"2016","journal-title":"Biofactors"},{"key":"key-10.4103\/2394-8108.249037-92","first-page":"993","volume-title":"Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-\u03b2 signaling pathway","author":"Kim","year":"2015","journal-title":"Phytomedicine"},{"key":"key-10.4103\/2394-8108.249037-93","first-page":"15113","volume-title":"Daidzein augments cholesterol homeostasis via apoE to promote functional recovery in chronic stroke","author":"Kim","year":"2015","journal-title":"J Neurosci"},{"key":"key-10.4103\/2394-8108.249037-94","first-page":"48","volume-title":"Daidzein inhibits carbohydrate digestive enzymes in vitro and alleviates postprandial hyperglycemia in diabetic mice","author":"Park","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-95","first-page":"136","volume-title":"Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in type 2 diabetic model mice","author":"Cheong","year":"2014","journal-title":"J Nutr Biochem"},{"key":"key-10.4103\/2394-8108.249037-96","first-page":"49","volume-title":"Daidzein supplementation decreases serum triglyceride and uric acid concentrations in hypercholesterolemic adults with the effect on triglycerides being greater in those with the GA compared with the GG genotype of ESR-\u03b2 rsaI","author":"Qin","year":"2014","journal-title":"J Nutr"},{"key":"key-10.4103\/2394-8108.249037-97","first-page":"656","volume-title":"Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet","author":"Guo","year":"2009","journal-title":"Nutr Res"},{"key":"key-10.4103\/2394-8108.249037-98","first-page":"50002","volume-title":"Therapeutic utility of natural estrogen receptor beta agonists on ovarian cancer","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"key-10.4103\/2394-8108.249037-99","first-page":"65","volume-title":"Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K\/AKT signaling in ovarian cancer","author":"Chan","year":"2018","journal-title":"Cancer Cell Int"},{"key":"key-10.4103\/2394-8108.249037-100","first-page":"3485","volume-title":"Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the raf\/MEK\/ERK cascade","author":"Hua","year":"2018","journal-title":"Int J Mol Med"},{"key":"key-10.4103\/2394-8108.249037-101","first-page":"116","volume-title":"Dietary isoflavone daidzein synergizes centchroman action via induction of apoptosis and inhibition of PI3K\/Akt pathway in MCF-7\/MDA MB-231 human breast cancer cells","author":"Kaushik","year":"2018","journal-title":"Phytomedicine"},{"key":"key-10.4103\/2394-8108.249037-102","doi-asserted-by":"crossref","unstructured":"Rigalli JP, Scholz PN, Tocchetti GN, Ruiz ML, Weiss J. The phytoestrogens daidzein and equol inhibit the drug transporter BCRP\/ABCG2 in breast cancer cells: Potential chemosensitizing effect. Eur J Nutr 2017;doi: 10.1007\/s00394-017-1578-9. [Epub ahead of print].","DOI":"10.1007\/s00394-017-1578-9"},{"key":"key-10.4103\/2394-8108.249037-103","first-page":"699","volume-title":"The impacts of genistein and daidzein on estrogen conjugations in human breast cancer cells: A targeted metabolomics approach","author":"Poschner","year":"2017","journal-title":"Front Pharmacol"},{"key":"key-10.4103\/2394-8108.249037-104","first-page":"3759","volume-title":"Daidzein suppresses tumor necrosis factor-\u03b1 induced migration and invasion by inhibiting hedgehog\/Gli1 signaling in human breast cancer cells","author":"Bao","year":"2014","journal-title":"J Agric Food Chem"},{"key":"key-10.4103\/2394-8108.249037-105","first-page":"542","volume-title":"Daidzein causes cytochrome c-mediated apoptosis via the bcl-2 family in human hepatic cancer cells","author":"Park","year":"2013","journal-title":"Food Chem Toxicol"}],"container-title":["Brain Circulation"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:38:57Z","timestamp":1786714737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_13_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"alternative-id":["249037"],"URL":"https:\/\/doi.org\/10.4103\/bc.bc_13_18","relation":{},"ISSN":["2394-8108"],"issn-type":[{"value":"2394-8108","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}