{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:32:15Z","timestamp":1787841135503,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>AIM:<\/jats:title>\n                    <jats:p>The purpose of this study is to investigate the safety and effectiveness of remote ischemic conditioning (RIC) as a therapeutic intervention for cerebral ischemia in patients with Takayasu arteritis (TA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>TARIC-1 is a randomized, double-blind, parallel-group pilot trial conducted at Xuanwu Hospital, Capital Medical University. Participants with TA and reduced cerebral blood perfusion are randomly allocated to either the RIC or sham-RIC groups. Both the groups receive conventional medical care, with the RIC group receiving twice-daily sessions of 200 mmHg inflation pressure and the sham-RIC group receiving 60 mmHg inflation pressure, for 24 consecutive weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OUTCOMES:<\/jats:title>\n                    <jats:p>The primary outcome is the change in mean cerebral blood flow across the entire brain and regions of interest following the 24-week RIC treatment. Secondary outcomes include clinical assessments using the Indian Takayasu Clinical Activity Score 2010, Vasculitis Damage Index, and Birmingham Vasculitis Activity Score at 24 weeks postintervention. Changes in arterial transit time and the incidence of major adverse cerebrovascular events are additional secondary outcomes. Safety outcomes include mortality and any adverse events, including skin changes and pain ratings, within the 24-week period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SAMPLE SIZE ESTIMATES:<\/jats:title>\n                    <jats:p>This pilot study plans to enroll 22 patients per group, totaling 44 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In individuals with TA, RIC may be a well-tolerated treatment that enhances cerebral perfusion and lowers the risk of ischemic cerebrovascular episodes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>TRIAL REGISTRATION:<\/jats:bold>\n                      http:\/\/www.clinicaltrials.gov (identifier: NCT06178419).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/bc.bc_162_24","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:00:09Z","timestamp":1768291209000},"page":"118-123","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Remote ischemic conditioning for cerebral ischemia in patients with Takayasu arteritis (TARIC-1): Study protocol"],"prefix":"10.4103","volume":"12","author":[{"given":"Shuangfeng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Elmadhoun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Division of Critical Care, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Neuro Cardio Vascular Diseases Center, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"R1-20260330","doi-asserted-by":"crossref","first-page":"919","DOI":"10.7326\/0003-4819-120-11-199406010-00004","article-title":"Takayasu arteritis","volume":"120","author":"Kerr","year":"1994","journal-title":"Ann Intern Med"},{"key":"R2-20260330","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1161\/STROKEAHA.120.030249","article-title":"Contemporary challenges of acute ischemic stroke in Takayasu arteritis","volume":"51","author":"Gao","year":"2020","journal-title":"Stroke"},{"key":"R3-20260330","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00415-018-8744-8","article-title":"Cerebrovascular events in Takayasu arteritis: A multicenter case-controlled study","volume":"265","author":"Couture","year":"2018","journal-title":"J Neurol"},{"key":"R4-20260330","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/rheumatology\/keab308","article-title":"Risk factors for cerebral infarction in Takayasu arteritis: A single-centre case-control study","volume":"61","author":"Kong","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"R5-20260330","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/STROKEAHA.121.034445","article-title":"Cerebrovascular ischemic events in patients with Takayasu arteritis","volume":"53","author":"Mirouse","year":"2022","journal-title":"Stroke"},{"key":"R6-20260330","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.12.005","article-title":"Stroke and transient ischemic attack in Takayasu's arteritis: A systematic review and meta-analysis","volume":"25","author":"Duarte","year":"2016","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"R7-20260330","first-page":"S0735","article-title":"Takayasu Arteritis:JACC Focus Seminar 3\/4","author":"Joseph","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"R8-20260330","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/art.41774","article-title":"2021 American College of Rheumatology\/vasculitis foundation guideline for the management of giant cell arteritis and takayasu arteritis","volume":"73","author":"Maz","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"R9-20260330","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.berh.2018.07.008","article-title":"Surgical intervention and its role in Takayasu arteritis","volume":"32","author":"Mason","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"R10-20260330","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13256-023-03752-0","article-title":"An unusual collateral from the sinoatrial nodal artery to the left carotid artery in a patient with Takayasu arteritis: A case report","volume":"17","author":"Beijk","year":"2023","journal-title":"J Med Case Rep"},{"key":"R11-20260330","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1161\/STROKEAHA.119.025494","article-title":"Remote ischemic conditioning as an additional treatment for acute ischemic stroke","volume":"50","author":"Landman","year":"2019","journal-title":"Stroke"},{"key":"R12-20260330","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/bc.bc_57_22","article-title":"Immune and inflammatory mechanism of remote ischemic conditioning: A narrative review","volume":"9","author":"Xu","year":"2023","journal-title":"Brain Circ"},{"key":"R13-20260330","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/acn3.588","article-title":"Remote ischemic conditioning for acute stroke patients treated with thrombectomy","volume":"5","author":"Zhao","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"key":"R14-20260330","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbr.2016.10.036","article-title":"Limb remote ischemic conditioning increases Notch signaling activity and promotes arteriogenesis in the ischemic rat brain","volume":"340","author":"Ren","year":"2018","journal-title":"Behav Brain Res"},{"key":"R15-20260330","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/bc.bc_33_23","article-title":"Optimal rehabilitation strategies for early postacute stroke recovery: An ongoing inquiry","volume":"9","author":"Tong","year":"2023","journal-title":"Brain Circ"},{"key":"R16-20260330","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/annrheumdis-2019-215672","article-title":"2018 update of the EULAR recommendations for the management of large vessel vasculitis","volume":"79","author":"Hellmich","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"R17-20260330","doi-asserted-by":"crossref","first-page":"e14507","DOI":"10.1111\/cns.14507","article-title":"Remote ischemic conditioning after stroke: Research progress in clinical study","volume":"30","author":"Jiang","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"R18-20260330","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/nur.20247","article-title":"Considerations in determining sample size for pilot studies","volume":"31","author":"Hertzog","year":"2008","journal-title":"Res Nurs Health"},{"key":"R19-20260330","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2478\/rir-2023-0004","article-title":"Clinical and vascular features of stroke in Takayasu's arteritis: A 24-year retrospective study","volume":"4","author":"Zhang","year":"2023","journal-title":"Rheumatol Immunol Res"},{"key":"R20-20260330","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3988\/jcn.2012.8.2.109","article-title":"Ischemic stroke in Takayasu's arteritis: Lesion patterns and possible mechanisms","volume":"8","author":"Hwang","year":"2012","journal-title":"J Clin Neurol"},{"key":"R21-20260330","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1148\/radiol.2018170509","article-title":"Monitoring cerebral perfusion changes after revascularization in patients with moyamoya disease by using arterial spin-labeling MR imaging","volume":"288","author":"Lee","year":"2018","journal-title":"Radiology"},{"key":"R22-20260330","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.3899\/jrheum.140664","article-title":"Clinical manifestations and longterm outcome for patients with Takayasu arteritis in China","volume":"41","author":"Yang","year":"2014","journal-title":"J Rheumatol"},{"key":"R23-20260330","first-page":"1296","article-title":"Pannexin1 channel-mediated inflammation in acute ischemic stroke","volume":"15","author":"Huang","year":"2024","journal-title":"Aging Dis"},{"key":"R24-20260330","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2147\/NDT.S231944","article-title":"Effects of remote ischemic conditioning on cerebral hemodynamics in ischemic stroke","volume":"16","author":"Qin","year":"2020","journal-title":"Neuropsychiatr Dis Treat"},{"key":"R25-20260330","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S1474-4422(22)00335-0","article-title":"Chronic remote ischaemic conditioning in patients with symptomatic intracranial atherosclerotic stenosis (the RICA trial): A multicentre, randomised, double-blind sham-controlled trial in China","volume":"21","author":"Hou","year":"2022","journal-title":"Lancet Neurol"},{"key":"R26-20260330","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1161\/STROKEAHA.117.017691","article-title":"Remote ischemic conditioning may improve outcomes of patients with cerebral small-vessel disease","volume":"48","author":"Wang","year":"2017","journal-title":"Stroke"},{"key":"R27-20260330","doi-asserted-by":"crossref","first-page":"811854","DOI":"10.3389\/fneur.2021.811854","article-title":"Daily remote ischemic conditioning can improve cerebral perfusion and slow arterial progression of adult moyamoya disease-A randomized controlled study","volume":"12","author":"Xu","year":"2021","journal-title":"Front Neurol"},{"key":"R28-20260330","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12975-015-0437-3","article-title":"Matched cohort analysis of the effects of limb remote ischemic conditioning in patients with aneurysmal subarachnoid hemorrhage","volume":"7","author":"Laiwalla","year":"2016","journal-title":"Transl Stroke Res"}],"container-title":["Brain Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_162_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:43:14Z","timestamp":1787838194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_162_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/bc.bc_162_24","relation":{},"ISSN":["2394-8108","2455-4626"],"issn-type":[{"value":"2394-8108","type":"print"},{"value":"2455-4626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"2024-11-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}