{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:53Z","timestamp":1787841113826,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"Abstract:<\/jats:title>\n \n BACKGROUND:<\/jats:title>\n Subarachnoid hemorrhage secondary to ruptured intracranial aneurysms compromise cerebral perfusion and oxygenation, threatening optimal cerebral function. This study explored the role of regional cerebral oxygenation monitoring in predicting outcomes in these patients.<\/jats:p>\n <\/jats:sec>\n \n METHODOLOGY:<\/jats:title>\n \n Fifty-two patients aged 18\u201365 years and scheduled for coiling of ruptured anterior circulation aneurysms participated in this prospective observational study. Bilateral regional cerebral oxygen saturation (rScO\n 2<\/jats:sub>\n ) was recorded during critically important phases of endovascular embolization under general anesthesia. rScO\n 2<\/jats:sub>\n was continuously monitored and recorded at critical stages of the procedure. Vital parameters and rScO\n 2<\/jats:sub>\n were collected at baseline, preinduction, postintubation, 5 min postintubation, and continuously after that, till the end of the procedure. Intraprocedural events such as contrast injection, sequential coil deployment, milrinone injections, and complications such as thromboembolism, coil migration, and aneurysmal rupture were event-marked, and the vital parameters along with bilateral near-infrared spectroscopy values were noted before and after each of these events. Cerebral desaturation episode (CDE) was defined as a drop in rScO\n 2<\/jats:sub>\n by 20% from baseline. Postprocedure, patients were monitored with a 24-h Glasgow Coma Scale during their hospital stay and a Glasgow outcome at discharge scale (GODS).\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Among the 52 recruited patients, 10 patients had CDEs. Increased frequency of CDEs correlated with the GODS score at discharge (\n P<\/jats:italic>\n = 0.040), length of hospital stay (\n P<\/jats:italic>\n < 0.001), duration of neurological deficit (\n P<\/jats:italic>\n = 0.001), and vasospasm (\n P<\/jats:italic>\n = 0.002).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n The frequency of CDEs and the trend of decline in rScO\n 2<\/jats:sub>\n from the baseline are predictive of an endangered hypoxic brain prone to secondary brain injuries, which guides the institution of prompt corrective measures.\n <\/jats:p>\n \n TRIAL REGISTRATION:<\/jats:bold>\n https:\/\/ctri.nic.in\/Clinicaltrials (identifier: CTRI\/2021\/09\/036253).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/bc.bc_166_24","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:00:12Z","timestamp":1752127212000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of cerebral oxygen saturation on outcomes of patients with ruptured intracranial aneurysms undergoing endovascular embolization: A prospective observational study"],"prefix":"10.4103","volume":"12","author":[{"given":"Parthiban","family":"Giribabu","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Sakra World Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Venkat","sequence":"additional","affiliation":[{"name":"Department of Neuroanesthesia and Neurocritical Care, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R. Madhusudan","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Neuroanesthesia and Neurocritical Care, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhritiman","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Neuroanesthesia and Neurocritical Care, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R.","family":"Aravinda","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha R.","family":"Palaniswamy","sequence":"additional","affiliation":[{"name":"Department of Neuroanesthesia and Neurocritical Care, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"R1-20260330","first-page":"256713","article-title":"Evidence-based cerebral vasospasm surveillance","author":"Kistka","year":"2013","journal-title":"Neurol Res Int 2013"},{"key":"R2-20260330","first-page":"CD003085","article-title":"Endovascular coiling versus neurosurgical clipping for patients with aneurysmal subarachnoid haemorrhage","author":"van der Schaaf","year":"2005","journal-title":"Cochrane Database 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