{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:09Z","timestamp":1787169969320,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n AIM:<\/jats:title>\n The principal objective of this study was to carry out a comprehensive and thorough analysis to compare the safety and effectiveness of the Arctic Sun, a servo-controlled surface cooling device, with conventional cooling techniques for providing therapeutic hypothermia in adult patients who had experienced hypoxic-ischemic brain injury following cardiopulmonary resuscitation.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n In order to achieve our goal, we conducted an extensive search of multiple databases including PubMed, Embase, Cochrane, and ClinicalTrials.gov up to the date of July 30, 2021. We only included studies that compared the safety and efficacy of the Arctic Sun surface cooling equipment with standard cooling approaches such as cooling blankets, ice packs, and intravenous cold saline for treating comatose adult patients who had recovered after experiencing cardiac arrest. We evaluated various outcomes, including all-cause mortality, good neurological outcome at 1 month, and the occurrence of adverse effects such as infections, shock, and bleeding. We employed a random-effects meta-analysis to estimate the odds ratio (OR) with 95% confidence intervals (CIs) for dichotomous outcomes.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n One hundred and fourteen records were identified through our search; however, only three studies met our eligibility criteria, resulting in overall 187 patients incorporated in the meta-analysis. The findings indicated no significant difference in mortality rates among the Arctic Sun device and conventional cooling techniques (OR: 0.64; 95% CI: 0.34\u20131.19;\n P<\/jats:italic>\n = 0.16;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 0%). In addition, we found no significant difference in occurrence of good neurological outcomes (OR: 1.74; 95% CI: 0.94\u20133.25;\n P<\/jats:italic>\n = 0.08;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 0%) between the two cooling methods. However, the application of the Arctic Sun device was associated with increased incidence of infections compared to standard cooling methods (OR: 2.46; 95% CI: 1.18\u20135.11;\n P<\/jats:italic>\n = 0.02;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 0%). While no significant difference occurred in the incidence of shock (OR: 0.29; 95% CI: 0.07\u20131.18;\n P<\/jats:italic>\n = 0.08;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 40%), the use of the Arctic Sun device was linked to significantly fewer bleeding complications compared to standard cooling methods (OR: 0.11; 95% CI: 0.02\u20130.79;\n P<\/jats:italic>\n = 0.03;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 0%).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n After analyzing the results of our meta-analysis, we concluded that the use of the Arctic Sun device for targeted temperature management following cardiopulmonary resuscitation did not result in significant differences in mortality rates or improve neurological outcomes when compared to standard cooling techniques.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/bc.bc_18_23","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T01:45:51Z","timestamp":1695692751000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of the Arctic Sun device for hypoxic-ischemic encephalopathy in adult patients following cardiopulmonary resuscitation: A systematic review and meta-analysis"],"prefix":"10.4103","volume":"9","author":[{"given":"Saurabh C.","family":"Sharda","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Acute Care and Emergency Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandip Singh","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Acute Care and Emergency Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit R.","family":"Jakhotia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Chaitanya Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Acute Care and Emergency Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Saroch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Acute Care and Emergency Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Pannu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Acute Care and Emergency Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Kumar H","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Acute Care and Emergency Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","year":"2002","journal-title":"N Engl J 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