{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:21:25Z","timestamp":1787757685170,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>We describe a case of a 36-year-old man who presented with stroke in the right paramedian pons in the pontine perforator territory, manifesting as intermittent headache, slurred speech, left-sided weakness, and paresthesia. This case highlights the diagnostic challenge in identifying neurosyphilis as a cause of stroke in young individuals. Clinicians should maintain vigilance for this uncommon etiology through conducting a detailed history and investigation in susceptible patients with key risk factors. Once the diagnosis was confirmed in our case, a multidisciplinary approach was used for management with neurologists, infectious disease specialists, and the neurointerventional team. Our patient ultimately underwent successful therapy with mechanical thrombectomy for basilar artery thrombosis from meningovascular syphilis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/bc.bc_39_21","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T07:06:05Z","timestamp":1640070365000},"page":"285-288","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Neurosyphilis presenting with a large vessel occlusion"],"prefix":"10.4103","volume":"7","author":[{"given":"Neeharika","family":"Krothapalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninad","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Tunguturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smit D.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240830","doi-asserted-by":"crossref","first-page":"1178633719883282","DOI":"10.1177\/1178633719883282","article-title":"Resurgence of syphilis in the united states: An assessment of contributing factors","volume":"12","author":"Schmidt","year":"2019","journal-title":"Infect Dis (Auckl"},{"key":"R2-11-20240830","doi-asserted-by":"crossref","first-page":"363","DOI":"10.15698\/mic2016.09.523","article-title":"Syphilis: Re-emergence of an old foe","volume":"3","author":"Stamm","year":"2016","journal-title":"Microb Cell"},{"key":"R3-11-20240830","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1001\/archneur.1989.00520440085024","article-title":"Neurosyphilis in acquired immunodeficiency syndrome","volume":"46","author":"Katz","year":"1989","journal-title":"Arch Neurol"},{"key":"R4-11-20240830","first-page":"703","article-title":"Neurosyphilis in HIV-positive and HIV-negative patients: Neuroimaging findings","volume":"16","author":"Brightbill","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"R5-11-20240830","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1345\/aph.1K086","article-title":"Reexamining syphilis: An update on epidemiology, clinical manifestations, and management","volume":"42","author":"Kent","year":"2008","journal-title":"Ann Pharmacother"},{"key":"R6-11-20240830","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1001\/jama.1972.03190320032011","article-title":"Neurosyphilis. A study of 241 patients","volume":"219","author":"Hooshmand","year":"1972","journal-title":"JAMA"},{"key":"R7-11-20240830","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1586\/erc.09.72","article-title":"Stroke in HIV infection and AIDS","volume":"7","author":"Dobbs","year":"2009","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"R8-11-20240830","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.07.046","article-title":"The great imitator--Still today! A case of meningovascular syphilis affecting the posterior circulation","volume":"24","author":"B\u00e4uerle","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"R9-11-20240830","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1212\/WNL.34.4.553","article-title":"Clinical features of meningovascular syphilis","volume":"34","author":"Holmes","year":"1984","journal-title":"Neurology"},{"key":"R10-11-20240830","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1212\/01.WNL.0000149758.57386.B8","article-title":"Meningovascular syphilis as a cause of basilar artery stenosis","volume":"64","author":"Flint","year":"2005","journal-title":"Neurology"},{"key":"R11-11-20240830","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1056\/NEJM194009192231204","article-title":"The early clinical and laboratory manifestations of syphilis of the central nervous system","volume":"223","author":"Merritt","year":"1940","journal-title":"N Eng J Med"},{"key":"R12-11-20240830","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1001\/jama.2016.4114","article-title":"Screening for syphilis: Updated evidence report and systematic review for the US preventive services task force","volume":"315","author":"Cantor","year":"2016","journal-title":"JAMA"},{"key":"R14-11-20240830","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1128\/AAC.21.6.984","article-title":"Comparison of the activities of ceftriaxone and penicillin G against experimentally induced syphilis in rabbits","volume":"21","author":"Johnson","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"key":"R15-11-20240830","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/MAJ.0b013e3181a40b81","article-title":"Meningovascular syphilis with fatal vertebrobasilar occlusion","volume":"338","author":"Feng","year":"2009","journal-title":"Am J Med Sci"},{"key":"R16-11-20240830","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ajem.2004.04.015","article-title":"Meningovascular syphilis and improvement with tissue-plasminogen activator (T-PA)","volume":"22","author":"Han","year":"2004","journal-title":"Am J Emerg Med"}],"container-title":["Brain Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_39_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:05Z","timestamp":1787755805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/bc.bc_39_21"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/bc.bc_39_21","relation":{},"ISSN":["2394-8108"],"issn-type":[{"value":"2394-8108","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}