{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:41:11Z","timestamp":1789965671796,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Antiphospholipid syndrome (APS) is known as a rare etiology of embolic ischemic stroke. In individuals below 50 years, up to 20% of strokes are associated with APS, whereas in patients &gt;50 years, it is considered a very seldom cause of stroke. We describe the course of a 66-year-old white woman, who experienced four embolic strokes with large vessel occlusion over a period of 2 years, which were repeatedly and successfully treated by mechanical thrombectomy. Initially attributed to atrial fibrillation and treated with direct oral anticoagulants, the patient was finally diagnosed with primary APS due to isolated anti-beta 2-glycoprotein antibodies and successfully treated after several stroke recurrences. After initiation of Vitamin K antagonist therapy, no further strokes occurred. For recurrent embolic stroke despite oral anticoagulation, late-onset APS might be considered a rare etiology also in the elderly.<\/jats:p>","DOI":"10.4103\/bc.bc_67_23","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:05:22Z","timestamp":1719374722000},"page":"184-187","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Primary antiphospholipid syndrome in the elderly: Four strokes and mechanical thrombectomies until the diagnosis - A case report"],"prefix":"10.4103","volume":"10","author":[{"given":"Anatoli","family":"Anastasiadi","sequence":"first","affiliation":[{"name":"Department of Neurology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bott","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kitterer","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Roser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Henkes","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansj\u00f6rg","family":"B\u00e4zner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"},{"name":"Department of Neurologische Klinik, Medizinische Fakult\u00e4t Mannheim, Universit\u00e4t Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum Stuttgart, Katharinen Hospital, Stuttgart, Germany"},{"name":"Department of Neurologische Klinik, Medizinische Fakult\u00e4t Mannheim, Universit\u00e4t Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1136\/annrheumdis-2014-205663","article-title":"The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events:A systematic review","volume":"74","author":"Sciascia","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(10)60709-X","article-title":"Antiphospholipid 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