{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:20:42Z","timestamp":1787764842348,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The necessity to modify silver diamine fluoride (SDF) to make it esthetically acceptable without affecting its beneficial properties keeps the research in this field pertinent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aims to comparatively evaluate the efficacy of Glutathione (GSH) in reducing tooth discoloration associated with SDF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This split-mouth\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      study was conducted on 20 children aged 3\u20138 years having a minimum of 3 active carious primary teeth. The three teeth in each patient were randomly divided into Group I \u2013 38% SDF; Group II \u2013 38% SDF followed by application of potassium iodide; and Group III \u2013 38% SDF mixed with 20% GSH. Standardized photographs were taken immediately after application and after 6 months, which were analyzed using Image J software. The carious lesions were clinically classified as active or arrested after 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      When mean gray values of three groups were compared postoperative, the highest value (lighter shade) was observed for group II and least (darker shade) for group I, whereas, during the 6-month follow-up, the highest value was seen for group III and least for group I. The color change from preoperative to 6 months\u2019 follow-up was compared, and a statistically significant difference was observed between groups I and II (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) and groups I and III (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). When caries arresting effectiveness was analyzed, there was no significant difference found between any of the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mixing 20% GSH with 38% SDF was an effective measure in reducing the tooth discoloration associated with SDF, without affecting caries arresting the efficiency of the latter.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_100_23","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T01:00:50Z","timestamp":1698195650000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Glutathione Biomolecule in Reducing the Tooth Discoloration Associated with Silver Diamine Fluoride: A Split-mouth In vivo Study"],"prefix":"10.4103","volume":"14","author":[{"given":"Y. 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