{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:41:24Z","timestamp":1789011684779,"version":"build-2803163510"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontal regeneration remains one of the crucial issues in the field of periodontology. Periodontal intrabony defects could be treated by surgical intervention through various alloplastic bone graft substitutes. The Food and Drug Administration approved, Novabone putty is one of the recently marketed bone graft substitutes, which has been used in the present study. This study also incorporates the placement of platelet-rich fibrin (PRF) in combination with Novabone putty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty patients were included in the study and were allocated to either Group A or Group B through randomization. Group A included the placement of Novabone putty in the periodontal intrabony defects, whereas Group B included the placement of Novabone putty along with PRF. Statistical analysis of plaque index, gingival index, probing pocket depth, relative attachment level, and intraoral periapical radiographs was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Statistical more significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) in probing pocket depth, and relative attachment level was observed in Group B (Novabone putty and PRF) in comparison to Group A (Novabone putty).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Evaluation of efficacy of Novabone putty along with PRF produced more favorable results in relative attachment level gain and more reduction in probing pocket depth when compared to Novabone putty alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_101_20","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T04:28:13Z","timestamp":1623644893000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Clinical and Radiographic Analysis of Novabone Putty with Platelet-Rich Fibrin in the Treatment of Periodontal Intrabony Defects"],"prefix":"10.4103","volume":"12","author":[{"given":"Vibhor","family":"Hazari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushree","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabbur Thipanna","family":"Chandrashekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashima","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranshu Kumar","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-8-20240901","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.coms.2007.06.001","article-title":"Bone replacement grafts for the treatment of periodontal intrabony defects","volume":"19","author":"Hanes","year":"2007","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"R3-8-20240901","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1902\/jop.1998.69.9.1027","article-title":"Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans","volume":"69","author":"Lovelace","year":"1998","journal-title":"J Periodontol"},{"key":"R4-8-20240901","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1902\/jop.1997.68.12.1186","article-title":"A phase I\/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease","volume":"68","author":"Howell","year":"1997","journal-title":"J Periodontol"},{"key":"R5-8-20240901","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R6-8-20240901","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-0757.2001.22250107.x","article-title":"Surgical periodontal therapy","volume":"25","author":"Wang","year":"2001","journal-title":"Periodontol 2000"},{"key":"R9-8-20240901","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sdentj.2013.12.001","article-title":"A review of the effect of various ions on the properties and the clinical applications of novel bioactive glasses in medicine and dentistry","volume":"26","author":"Ali","year":"2014","journal-title":"Saudi Dent J"},{"key":"R10-8-20240901","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-0757.1993.tb00210.x","article-title":"Synthetic bone grafts in periodontics","volume":"1","author":"Yukna","year":"1993","journal-title":"Periodontol 2000"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_101_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:17:02Z","timestamp":1787843822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_101_20"}},"subtitle":["A Randomized Control Trial"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_101_20","relation":{},"ISSN":["0976-237X"],"issn-type":[{"value":"0976-237X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}