{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:37:35Z","timestamp":1787841455931,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontal ligament-associated protein-1 (PLAP-1)\/asporin is an extracellular matrix protein that plays a protective role in the pathogenesis of periodontitis. There is a paucity of information about the association between PLAP-1\/asporin and periodontitis in human PDL. Thus, in this study, PLAP-1\/asporin levels between participants with healthy periodontium and chronic periodontitis were compared and correlated with periodontal parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Fifty participants were recruited and divided into 25 in each group: Group 1 (control) and Group 2 (test). Probing pocket depth (PPD) and clinical attachment level (CAL) were recorded. Periodontal ligament (PDL) samples were collected from extracted teeth for estimating PLAP-1\/asporin levels using the Human Asporin Enzyme-Linked Immunoassay Kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A statistically significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) in the PLAP-1\/asporin levels was observed between Group 1 and Group 2. A weak negative correlation was observed between PLAP-1\/asporin levels and periodontal parameters (PPD and CAL) in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this study, higher PLAP-1\/asporin levels in participants with healthy periodontium highlight the protective role of PLAP-1\/asporin in maintaining periodontal homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_114_23","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T15:43:14Z","timestamp":1720539794000},"page":"143-146","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Periodontal Ligament-associated Protein-1\/Asporin Levels in Periodontal Tissue in Health and Disease"],"prefix":"10.4103","volume":"15","author":[{"given":"Madhu Priya","family":"Manohar","sequence":"first","affiliation":[{"name":"Department of Periodontology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth Deemed to be University, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Saravana","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth Deemed to be University, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratebha","family":"Balu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth Deemed to be University, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0757.2005.00141.x","article-title":"Structure of periodontal tissues in health and disease","volume":"40","author":"Nanci","year":"2006","journal-title":"Periodontol 2000"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(01)00683-7","article-title":"Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene","volume":"275","author":"Yamada","year":"2001","journal-title":"Gene"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1074\/jbc.M010932200","article-title":"Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan","volume":"276","author":"Lorenzo","year":"2001","journal-title":"J Biol Chem"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/154405910608500510","article-title":"Regulation of PLAP-1 expression in periodontal ligament cells","volume":"85","author":"Yamada","year":"2006","journal-title":"J Dent Res"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2008.03.158","article-title":"PLAP-1\/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif","volume":"371","author":"Tomoeda","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"R6-20260507","doi-asserted-by":"crossref","first-page":"23070","DOI":"10.1074\/jbc.M611181200","article-title":"PLAP-1\/asporin, a novel negative regulator of periodontal ligament mineralization","volume":"282","author":"Yamada","year":"2007","journal-title":"J Biol Chem"},{"key":"R7-20260507","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/0022034513520549","article-title":"Inhibitory effects of PLAP-1\/asporin on periodontal ligament cells","volume":"93","author":"Kajikawa","year":"2014","journal-title":"J Dent Res"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1177\/0022034515606859","article-title":"PLAP-1\/asporin regulates TLR2- and TLR4-induced inflammatory responses","volume":"94","author":"Yamaba","year":"2015","journal-title":"J Dent Res"},{"key":"R9-20260507","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/jre.12618","article-title":"Periodontal ligament-associated protein-1 gets involved in experimental periodontitis","volume":"54","author":"Yu","year":"2019","journal-title":"J Periodontal Res"},{"key":"R10-20260507","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.archoralbio.2015.11.010","article-title":"Asporin in compressed periodontal ligament cells inhibits bone formation","volume":"62","author":"Ueda","year":"2016","journal-title":"Arch Oral Biol"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_114_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:55:39Z","timestamp":1787838939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_114_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_114_23","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-03-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}