{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:41Z","timestamp":1790171981122,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to compare the clinical and radiographic effects of EndoSeal mineral trioxide aggregate (MTA) and MTA for pulpotomy of primary teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This split-mouth randomized clinical trial evaluated 45 pairs of bilateral asymptomatic severely carious primary molars requiring pulpotomy in children between 3 and 8 years. The teeth in each patient were randomly assigned to two groups to undergo pulpotomy with MTA and EndoSeal MTA (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45 in each group). After application of the pulpotomy agent on the radicular pulp tissue, the pulp chamber was filled with zinc oxide eugenol, and the tooth was restored with a stainless-steel crown. The teeth were clinically and radiographically assessed after 3 and 6 months using the Zurn and Seale modified scale. Data were analyzed using the Wilcoxon signed-rank test and a generalized estimating equation model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both groups demonstrated a 100% clinical success rate at 3 and 6 months. Radiographic success rates were 95.6% (3 months) and 93.3% (6 months) for the MTA group, and 93.3% (3 months) and 91.1% (6 months) for the EndoSeal MTA group. The difference in radiographic success was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.631).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Within the limitations of this study, EndoSeal MTA demonstrated comparable clinical and radiographic success to MTA for pulpotomy of primary molars, suggesting it may be a suitable alternative material.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_131_25","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:01:19Z","timestamp":1790078479000},"page":"158-164","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Radiographic Evaluation of EndoSeal MTA Versus MTA in Primary Tooth Pulpotomy: A Randomized Clinical Trial"],"prefix":"10.4103","volume":"17","author":[{"given":"Fatemeh","family":"Taghizadeh","sequence":"first","affiliation":[{"name":"Pedodontist Private Office, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Haghgoo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Shahed University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Labbaf","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Shahed University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Mehran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Shahed University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Ghanbari","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Shahed University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"R2-20260923","first-page":"508","article-title":"Comparative evaluation of clinical and radiographic success of MTA and propolis in pulpotomy of primary molars","volume":"13","author":"Aghazadeh","year":"2018","journal-title":"Iran Endod J"},{"key":"R3-20260923","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/1735-3327.330881","article-title":"The clinical and radiographic evaluation of Allium sativum oil (garlic oil) in comparison with mineral trioxide aggregate in primary molar pulpotomy","volume":"18","author":"Faghihi","year":"2021","journal-title":"Dent Res J (Isfahan)"},{"key":"R4-20260923","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3390\/bioengineering10030354","article-title":"Bioceramics in endodontics: Updates and future perspectives","volume":"10","author":"Dong","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"R5-20260923","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/sca.21231","article-title":"Comparison of bacterial leakage resistance of various root canal filling materials and methods: Confocal laser-scanning microscope study","volume":"37","author":"Hwang","year":"2015","journal-title":"Scanning"},{"key":"R6-20260923","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12903-015-0112-9","article-title":"Physical properties and biocompatibility of an injectable calcium-silicate-based root canal sealer: In vitro and in vivo study","volume":"15","author":"Lim","year":"2015","journal-title":"BMC Oral 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Endod"},{"key":"R10-20260923","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4012\/dmj.2013-171","article-title":"Cytotoxicity of a novel mineral trioxide aggregate-based root canal sealer [corrected]","volume":"33","author":"Kim","year":"2014","journal-title":"Dent Mater J"},{"key":"R11-20260923","first-page":"e90718","article-title":"Bioactive materials in pediatric endodontics: Current applications and future directions","volume":"17","author":"Alshalan","year":"2025","journal-title":"Cureus"},{"key":"R12-20260923","doi-asserted-by":"crossref","first-page":"e18198","DOI":"10.7717\/peerj.18198","article-title":"Effect of bioceramic-based and resin-based sealers on postoperative discomfort following root canal therapy: A systematic review and meta-analysis","volume":"12","author":"Supare","year":"2024","journal-title":"PeerJ"},{"key":"R13-20260923","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/jfb16010014","article-title":"An evaluation of the biocompatibility and chemical properties of two bioceramic root canal sealers in a sealer extrusion model of rat molars","volume":"16","author":"Takahara","year":"2025","journal-title":"J Funct Biomater"},{"key":"R14-20260923","first-page":"283","article-title":"Mineral trioxide aggregate as pulp dressing agent in Pulpotomy treatment of primary molars: 42-month clinical study","volume":"20","author":"Maroto","year":"2007","journal-title":"Am J Dent"},{"key":"R17-20260923","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.21608\/edj.2019.72582","article-title":"Biocompatibility and osteogenic potential of the new bioceramic endodontic material \"EndoSeal MTA\"","volume":"65","author":"Rehan","year":"2019","journal-title":"Egypt Dent J"},{"key":"R18-20260923","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/jbm.b.32744","article-title":"Biocompatibility of an experimental MTA sealer implanted in the rat subcutaneous: Quantitative and immunohistochemical evaluation","volume":"100","author":"Viola","year":"2012","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"R19-20260923","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00784-012-0782-5","article-title":"Characteristics of novel root-end filling material using epoxy resin and Portland cement","volume":"17","author":"Lee","year":"2013","journal-title":"Clin Oral Investig"},{"key":"R20-20260923","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.archoralbio.2013.04.002","article-title":"Influence of a bioceramic root end material and mineral trioxide aggregates on fibroblasts and osteoblasts","volume":"58","author":"Willershausen","year":"2013","journal-title":"Arch Oral Biol"},{"key":"R21-20260923","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jds.2017.10.007","article-title":"Comparison of antimicrobial activity of traditional and new developed root sealers against pathogens related root canal","volume":"13","author":"Shin","year":"2018","journal-title":"J Dent Sci"},{"key":"R23-20260923","first-page":"96","article-title":"Comparison of bacterial microleakage of endoseal MTA sealer and pro-root MTA in root perforation","volume":"22","author":"Dastorani","year":"2021","journal-title":"J Dent (Shiraz)"},{"key":"R24-20260923","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0917-2394(11)70240-3","article-title":"The formaldehyde inspiration by the child patient, dentist, and dental assistant during formocresol pulpotomy","volume":"21","author":"Arai","year":"2011","journal-title":"Pediatr Dent J"},{"key":"R25-20260923","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1067\/moe.2002.117803","article-title":"Influence of root canal dressings and sealers on repair of apical periodontitis after endodontic treatment","volume":"93","author":"Berbert","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol 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Biomater"},{"key":"R29-20260923","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/iej.12231","article-title":"Comparison of pulp response to mineral trioxide aggregate and a bioceramic paste in partial pulpotomy of sound human premolars: A randomized controlled trial","volume":"47","author":"Azimi","year":"2014","journal-title":"Int Endod J"},{"key":"R30-20260923","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.joen.2014.04.006","article-title":"In vitro biocompatibility, inflammatory response, and osteogenic potential of 4 root canal sealers: Sealapex, Sankin apatite root sealer, MTA Fillapex, and iRoot SP root canal sealer","volume":"40","author":"Chang","year":"2014","journal-title":"J Endod"},{"key":"R31-20260923","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/iej.12203","article-title":"Subcutaneous connective tissue reactions to iRoot SP, mineral trioxide aggregate (MTA) Fillapex, DiaRoot BioAggregate and MTA","volume":"47","author":"B\u00f3sio","year":"2014","journal-title":"Int Endod J"},{"key":"R32-20260923","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/iej.12082","article-title":"BioAggregate and iRoot BP Plus optimize the proliferation and mineralization ability of human dental pulp cells","volume":"46","author":"Zhang","year":"2013","journal-title":"Int Endod J"},{"key":"R33-20260923","first-page":"2582849","article-title":"Physicochemical properties of epoxy resin-based and bioceramic-based root canal sealers","author":"Lee","year":"2017","journal-title":"Bioinorg Chem Appl 2017"}],"container-title":["Contemporary Clinical 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