{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:16:57Z","timestamp":1787847417518,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"\n Context:<\/jats:title>\n \n Although\n Lactobacilli<\/jats:italic>\n as a probiotic was established as a treatment for a wide range of systemic infections, its role in periodontitis and oral microbiota is still under investigation.\n <\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n The present randomized clinical trial was aimed to evaluate the effects of probiotic chewable tablets containing\n Lactobacillus reuteri UBLRu-87<\/jats:italic>\n along with initial periodontal therapy on clinical parameters and oral microbiota of chronic periodontitis (CP) patients.\n <\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n The randomized controlled clinical trial.<\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods:<\/jats:title>\n \n Thirty CP patients were selected who received scaling and root planing (SRP) and were randomly allocated into two treatment groups; Groups A and B. Group A received\n L. reuteri<\/jats:italic>\n -containing chewable probiotic tablets. The clinical parameters (plaque index, gingival index, probing pocket depth, clinical attachment level), and microbiological parameters (\n Porphyromonas gingivalis<\/jats:italic>\n and\n L. reuteri<\/jats:italic>\n levels using real-time polymerase chain reaction) were evaluated at baseline, following treatment at 1 month and 3 months in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n \n Paired\n t<\/jats:italic>\n -test and unpaired\n t<\/jats:italic>\n -test were used for the statistical analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n On intergroup analysis, statistically significant improvement in clinical as well as microbiological parameters was observed in Group A (SRP + PROBIOTIC) compared to Group B (SRP ALONE) at all evaluation time points.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Probiotic chewable tablets containing\n L. reuteri<\/jats:italic>\n may be a useful adjunct along with initial periodontal therapy to slow recolonization of periopathogens along with improvement in clinical outcomes of CP. Further long-term trials are necessary to establish the optimal dosage of probiotics.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ccd.ccd_135_20","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T04:28:13Z","timestamp":1623644893000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Oral Microbial Shift Following 1-Month Supplementation of Probiotic Chewable Tablets Containing Lactobacillus reuteri UBLRu-87 as an Adjunct to Phase 1 Periodontal Therapy in Chronic Periodontitis Patients"],"prefix":"10.4103","volume":"12","author":[{"given":"A. Aysha","family":"Jebin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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