{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:45Z","timestamp":1787071065323,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Osteopoikilosis (OPK) is a rare benign bone dysplasia characterized by the presence of multiple radiodense patches scattered throughout the skeleton\u2019s trabecular bone. It presents as small well-demarcated bone lesions of variable sizes and of a sclerotic nature. OPK is a benign bone pathology that requires no treatment but monitoring and management of possible symptoms. This case highlights the incidental finding of an asymptomatic OPK in the mandible of a patient seeking orthodontic treatment; OPK manifestation in the mandible was rarely reported before. Radiologic and clinical diagnoses, along with the family history, confirmed the differential diagnosis of OPK. Such a differential diagnosis includes a range of serious conditions such as osteoblastic metastasis and tuberous sclerosis, making the correct diagnosis of OPK essential for overtreatment prevention. Treatment consisted of patient education, follow-up, and anti-inflammatory drugs in case of symptomatic flare-ups. This article reports on a case of OPK presenting lesions in the mandible as well as in other bones of the skeleton; such a manifestation of OPK in the cranium and specifically in the mandible is considered extremely rare.<\/jats:p>","DOI":"10.4103\/ccd.ccd_161_25","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:00:15Z","timestamp":1761984015000},"page":"214-217","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Osteopoikilosis in the Mandible"],"prefix":"10.4103","volume":"16","author":[{"given":"Mohamad","family":"Fardoun","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Cedars Siani Hospital, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Bou Assi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon"},{"name":"Department of Orthodontics and Dentofacial Orthopedics, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s003300000495","article-title":"Sclerosing bone dysplasias: Genetic and radioclinical features","volume":"10","author":"Vanhoenacker","year":"2000","journal-title":"Eur Radiol"},{"key":"R3-20260420","first-page":"e20240058","article-title":"Sclerosing bone dysplasias: A pictorial essay","volume":"57","author":"Galdino","year":"2024","journal-title":"Radiol Bras"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00296-010-1664-2","article-title":"A rare benign disorder mimicking metastasis on radiographic examination: A case report of osteopoikilosis","volume":"31","author":"Ozdemirel","year":"2011","journal-title":"Rheumatol Int"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00296-011-2072-y","article-title":"Case report of a patient with osteopoikilosis","volume":"32","author":"Inci","year":"2012","journal-title":"Rheumatol Int"},{"key":"R6-20260420","first-page":"415","article-title":"Radiological case of the month. 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