{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:13:48Z","timestamp":1792030428562,"version":"4.4.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Sclerostin is an inhibitor of bone formation, and laser irradiation enhances osteoblast proliferation. The objective of this study was to assess and compare the gingival crevicular fluid (GCF) sclerostin level and clinical parameters of chronic periodontitis patients following the application of diode laser (810 nm) as an adjunct to scaling and root planing (SRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>\n                      Fifteen systemically healthy chronic periodontitis patients (age 35\u201355 years) with probing pocket depth \u22655mm were included in this split-mouth study. SRP and pocket irradiation with diode laser were done in the test group and SRP alone in the control group at baseline. Low-level laser therapy application and saline irrigation were done in both the groups, respectively, in the 2\n                      <jats:sup>nd<\/jats:sup>\n                      and 3\n                      <jats:sup>rd<\/jats:sup>\n                      visits. Two microliters of GCF samples was collected from both the groups at baseline before treatment and on the 90\n                      <jats:sup>th<\/jats:sup>\n                      day for the assessment of sclerostin concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This study showed a statistically significant reduction of clinical parameters in the test and control groups at the end of 3 months. Both the groups showed a statistically significant reduction of sclerostin levels in GCF after 3 months, in which the test group (125.80 \u00b1 28.21 to 82.80 \u00b1 9.31) showed a highly significant reduction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The adjunctive use of laser had shown a beneficial effect in terms of clinical parameters and osteoblast proliferation by the reduction in the levels of sclerostin in GCF. From the observations of this study, it can be concluded that the therapeutic effectiveness of diode laser as an adjunct to SRP is having a beneficial effect and sclerostin can be used as a potent biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_19_20","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T12:53:32Z","timestamp":1632228812000},"page":"276-281","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Comparative Evaluation of Sclerostin Levels in Gingival Crevicular Fluid in the Treatment of Chronic Periodontitis Patients Using Diode Laser as an Adjunct to Scaling and Root Planing: A Clinico-biochemical Study"],"prefix":"10.4103","volume":"12","author":[{"given":"B. S. Jagadish","family":"Pai","sequence":"first","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithya R.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Walveker","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedevi","family":"Keeneri","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansu","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neethi R","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menezes Anosca","family":"Lira","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, 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