{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:13:05Z","timestamp":1789524785248,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple endocrine neoplasia (MEN) 2B syndrome is a rare autosomal dominant hereditary condition of neuroendocrine origin characterized by pheochromocytoma, marfanoid habitus, and mucocutaneous neuromas. Multiple mucosal neuromas on the tongue, lips, cheeks, and inner eyelids are often appeared as the earliest signs in most of the undiagnosed cases. Early diagnoses, recognition of phenotype, adequate surgery, and appropriate genetic counseling are very much essential as patients often develop medullary thyroid carcinoma (MTC) and pheochromocytoma. This case report would highlight the oral manifestations of MEN 2B in a 22-year-old female patient with multiple mucosal neuromas and a previous history of thyroidectomy due to MTC.<\/jats:p>","DOI":"10.4103\/ccd.ccd_215_23","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T06:00:23Z","timestamp":1711173623000},"page":"54-57","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Oral Manifestations of Multiple Endocrine Neoplasia 2B Syndrome: A Rare Case Report"],"prefix":"10.4103","volume":"15","author":[{"given":"Sohini","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Periodontics, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debkamal","family":"Kar","sequence":"additional","affiliation":[{"name":"Private Practitioner, Oral and Maxillofacial Pathologist, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"R1-20240901","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0030-4220(76)90187-0","article-title":"Mucosal ganglioneuromatosis, medullary thyroid carcinoma, and pheochromocytoma: Multiple endocrine neoplasia, type 2B","volume":"41","author":"Carney","year":"1976","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R2-20240901","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1210\/jc.2018-02102","article-title":"Fifty years after the first description, men 2B syndrome diagnosis is still late: Descriptions of two recent cases","volume":"104","author":"Elisei","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"R3-20240901","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4291\/wjgp.v8.i3.142","article-title":"Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa","volume":"8","author":"Hutson","year":"2017","journal-title":"World J Gastrointest Pathophysiol"},{"key":"R4-20240901","first-page":"208","article-title":"Oral mucosal neuromas leading to the diagnosis of multiple endocrine neoplasia type 2B in a child with intestinal pseudo-obstruction","volume":"3","author":"Qualia","year":"2007","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"R5-20240901","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajoms.2019.11.003","article-title":"Multiple endocrine neoplasia type 2B: Maxillofacial finding in one case","volume":"32","author":"Abdullah","year":"2020","journal-title":"J Oral Maxillofac Surg Med Pathol"},{"key":"R6-20240901","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4103\/jomfp.JOMFP_127_20","article-title":"Multiple endocrine neoplasia type 2B: A report of a rare case","volume":"24","author":"Ningombam","year":"2020","journal-title":"J Oral Maxillofac Pathol"},{"key":"R7-20240901","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12020-021-02607-2","article-title":"Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: A case series","volume":"72","author":"van den Broek","year":"2021","journal-title":"Endocrine"},{"key":"R8-20240901","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/jmg.33.9.779","article-title":"Multiple endocrine neoplasia type 2B (mucosal neuroma syndrome, Wagenmann-Froboese syndrome)","volume":"33","author":"Morrison","year":"1996","journal-title":"J Med Genet"},{"key":"R9-20240901","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1634\/theoncologist.2014-0277","article-title":"Epidemiology, clinical features, and genetics of multiple endocrine neoplasia type 2B in a complete population","volume":"19","author":"Znaczko","year":"2014","journal-title":"Oncologist"},{"key":"R10-20240901","first-page":"17","article-title":"Four cases of mucosal neuroma syndrome: Multiple endocrine neoplasm 2B or not 2B?","volume":"83","author":"Gordon","year":"1998","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_215_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:30:39Z","timestamp":1787769039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_215_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_215_23","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-05-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}